Supplement
Beta-hydroxyisovaleric acid clinical trials
Also written HMB.
- studies test it
- 34
- open now
- 8
- in phase 3
- 1
- first study started
- 2008
Keep track of what changes. Save the beta-hydroxyisovaleric acid studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
Other names
- HMB
- 17
Studies by the year they started
34 studies that test it; most in 2026 (6)
| Year | Studies |
|---|---|
| 2008 | 1 |
| 2012 | 3 |
| 2014 | 3 |
| 2015 | 2 |
| 2016 | 3 |
| 2017 | 2 |
| 2018 | 3 |
| 2019 | 2 |
| 2021 | 4 |
| 2022 | 2 |
| 2023 | 1 |
| 2024 | 1 |
| 2025 | 1 |
| 2026 | 6 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 3
- Phase 2
- 3
- Phase 3
- 1
- Phase 4
- 1
- No phase
- 27
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 6 · Other 28
Metabolic Technologies Inc. (6) · University of Roma La Sapienza (2) · Universidad de Burgos (1) · Gillette Children's Specialty Healthcare (1) · Okan University (1) · Kowloon Hospital, Hong Kong (1) · Gerald Supinski (1) · Mette M Berger (1)
Often tested with
Tested in the same studies.
Eicosapentaenoic Acid (2) · Vitamin D (2) · Creatine monohydrate (1) · Creatine (1) · Cholecalciferol (1) · Adenosine Triphosphate (1) · Resveratrol (1) · Sodium (1)
Studies
Open first, then newest update. How each study uses beta-hydroxyisovaleric acid is read from its arms, and is right about nine times in ten.
Testing it · 34
- HMB Enriched Amino Acids to Reverse Muscle Loss in CirrhosisRecruitingNot applicableThe Cleveland ClinicNCT05166499Written as Hydroxy Methyl Butyrate
- Pilot Trial Utilizing β-hydroxy-β-methylbutyrate to Lower IGFBP7 Levels in People With ALSNot yet recruitingPhase 1Duke UniversityNCT07589764Written as β-hydroxy-β-methylbutyrate (HMB)
- High-Protein Diet and HMB Supplementation in Patients With Heart FailureNot yet recruitingNot applicableHospital de Clinicas de Porto AlegreNCT07731048Written as β-Hydroxy-β-Methylbutyrate (HMB)
- Impact of HMB Supplementation on Inflammation and Outcomes in Head and Neck CancerRecruitingNot applicableFederal University of Minas GeraisNCT07675421Written as HMB, hydroxymethylbutyrate
- Exercise and/or HMB in Older Diabetes With Low Muscle MassNot yet recruitingNot applicableWu ShanglingNCT07142941Written as HMB
- Effects of HMB and Rehabilitation Program in Athletes With Patellar TendinopathyNot yet recruitingNot applicableUniversidad Complutense de MadridNCT07466407Written as Beta-hydroxy-beta-methylbutyrate (HMB)
- Influence of β-hydroxy β-methyl Butyrate (HMB)Supplementation on Post-operative Muscle Mass and Function in Female AthletesRecruitingPhase 2University of Kansas Medical CenterNCT05869812Written as CaHMB (Dietary supplement, not Drug)
- High-protein Oral Nutrition With HMB for Active CD Patients With SarcopeniaEnrolling by invitationNot applicableSixth Affiliated Hospital, Sun Yat-sen UniversityNCT07171593Written as HMB
- Evaluation of Hydroxymethylbutyrate Supplementation in Lung Transplant Candidates Receiving Pulmonary RehabilitationCompletedNot applicableOkan UniversityNCT07660991Written as HMB
- Neuromuscular and Multi-Omics Synergy of Combined Creatine × HMB Supplementation Plus Exercise to Improve Muscle Function in Sarcopenic FrailtyActive, not recruitingNot applicableUniversidad de BurgosNCT07275996Written as β-Hydroxy-β-Methylbutyrate (HMB)
- Efficacy of Structured Exercise-Nutritional Intervention on Sarcopenia in Patients With OsteoporosisCompletedNot applicableKowloon Hospital, Hong KongNCT06287502Written as β-hydroxy β-methylbutyrate (HMB)
- HMB Cerebral Palsy Pilot StudyActive, not recruitingNot applicableGillette Children's Specialty HealthcareNCT05384951Written as HMB + Vitamin D3
- Salt and HMB StudyStatus unknownNot applicableAugusta UniversityNCT05515900Written as HMB
- Resistance Exercise or Vibration With HMB for SarcopeniaStatus unknownNot applicableChinese University of Hong KongNCT04028206Written as Hydroxymethylbutyrate
- Effects of Nutritional Preconditioning on the Patient's Outcomes After SurgeryStatus unknownNot applicableUniversity of California, San FranciscoNCT03692507Written as HMB
- Strategies to Reduce Organic Muscle Atrophy in the Intensive Care UnitWithdrawnPhase 2/3Massachusetts General HospitalNCT02773771Written as beta-hydroxy-beta-methylbutyrate
- Effect of EPA and HMB on Strength in ICU PatientsCompletedNot applicableGerald SupinskiNCT01270516Written as HMB, hydroxymethylbutyrate
- A Study to Investigate the Effect of HMB on Skeletal Muscle Wasting in Early Critical IllnessStatus unknownPhase 2Guy's and St Thomas' NHS Foundation TrustNCT03464708Written as HMB
- Effect of Supplementation With HMB and Glutamine in Wound Healing on Bloody AreasStatus unknownPhase 4Hospital General de MexicoNCT03782155Written as HMB
- Can Beta-Hydroxy-beta-Methylbutyrate Supplementation Counteract Muscle Catabolism in Critically Ill Patients?CompletedNot applicableMette M BergerNCT03628365Written as HMB (beta-hydroxy beta-methylbutyrate)
See all 34 studies that test beta-hydroxyisovaleric acid →
As the comparator · 1 — what is tested is compared with beta-hydroxyisovaleric acid
Codes
What other systems call beta-hydroxyisovaleric acid · ClinicalTrials.gg INT002309
- MeSH (NLM) C004961beta-hydroxyisovaleric acidOne source NLM
- UNII (FDA) 3F752311CD.BETA.-HYDROXYISOVALERIC ACIDConfirmed FDA, NLM
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C004961 | beta-hydroxyisovaleric acid | One source NLM |
| UNII (FDA) | 3F752311CD | .BETA.-HYDROXYISOVALERIC ACID | Confirmed FDA, NLM |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.