Vitreoretinopathy, Proliferative clinical trials
The registry lists 43 studies for Vitreoretinopathy, Proliferative across more than 10 countries. 11 are recruiting or about to start. 25 of them are mainly about Vitreoretinopathy, Proliferative (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Who runs them
Shahid Beheshti University of Medical Sciences (6) · Wills Eye (3) · University College, London (2) · Central Hospital, Nancy, France (2) · Massachusetts Eye and Ear Infirmary (2) · Benha University (2) · Unity Health Toronto (2) · Ahalia Foundation Eye Hospital (1)
What is being tested here
Drugs under test in Vitreoretinopathy, Proliferative studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Methotrexate | 2 | 2 | 5 |
| Topotecan | 2 | 0 | 2 |
| Netarsudil | 1 | 1 | 2 |
| Triamcinolone | 0 | 1 | 3 |
| Triamcinolone Acetonide | 0 | 1 | 2 |
| Bevacizumab | 0 | 0 | 2 |
| Colchicine | 0 | 2 | 2 |
| Heparin, Low-Molecular-Weight | 0 | 2 | 2 |
| Fluorouracil | 0 | 2 | 2 |
| Enoxaparin sodium | 0 | 0 | 1 |
Drug classes tested here Antimetabolites 2 open · Corticosteroids 4 · Angiogenesis inhibitors 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4
- Jan 2027Study of Imaging and Molecular Biomarkers in Uncomplicated Rhegmatogenous Retinal Detachment · University College, London
- Apr 2027Intravitreal Topotecan for Prevention or Treatment of Proliferative Vitreoretinopathy in Retinal Detachment · Unity Health Toronto
- Jul 2027REtinal Detachment Outcomes Study · CHU de Quebec-Universite Laval
- Oct 2027Imaging and Predictive Modelling of Proliferative Vitreoretinopathy. · University College, London
Who these studies take
Of the 6 Vitreoretinopathy, Proliferative studies recruiting now, 5 (83%) set no upper age limit and 1 (17%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (17%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 5 (83%) | 5 (83%) |
| 30 | 6 (100%) | 6 (100%) |
| 40 | 6 (100%) | 6 (100%) |
| 50 | 6 (100%) | 6 (100%) |
| 65 | 6 (100%) | 6 (100%) |
| 75 | 5 (83%) | 5 (83%) |
| 85 | 5 (83%) | 5 (83%) |
Across all 43 studies, recruiting or not: 14% stop at 75 or younger and 12% at 65; 14% take children; 0% are for women only and 5% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 43 of 43. search them.
- REtinal Detachment Outcomes StudyRecruitingNCT05863312Not applicable1 country
- A Proof-Of-Concept (POC) Study of SFG-02 Transdermal Formulation in Participants With Underactive Bladder (UAB)RecruitingNCT07906106Phase 21 country
- Prevention of ProliFerative Vitreoretinopathy With Intravitreal MethotreXate in Primary Retinal DEtachment Repair (FIXER) TrialRecruitingNCT06541574Phase 21 country
- The Safety and Efficacy of Intravitreal Topotecan for the Treatment of Proliferative VitreoretinopathyNot yet recruitingNCT06425419Phase 1
- Topical Netarsudil for the Prevention of Proliferative Vitreoretinopathy in Patients With Retinal DetachmentRecruitingNCT06033703Phase 1/21 country
- Imaging and Predictive Modelling of Proliferative Vitreoretinopathy.Enrolling by invitationNCT076820251 country
- Study of Imaging and Molecular Biomarkers in Uncomplicated Rhegmatogenous Retinal DetachmentNot yet recruitingNCT073866781 country
- Intravitreal Topotecan for Prevention or Treatment of Proliferative Vitreoretinopathy in Retinal DetachmentNot yet recruitingNCT06818721Phase 21 country
- Intravitreal Topotecan in the Repair of Rhegmatogenous Retinal Detachment with Proliferative VitreoretinopathyRecruitingNCT05523869Phase 21 country
- "Comparing Methotrexate Usage Techniques to Prevent Proliferative Vitreoretinopaty After Retinal Detachment Vitrectomy"RecruitingNCT06289205Phase 1/21 country
- Internal Limiting Membrane Peeling in Retinal Detachment SurgeryNot yet recruitingNCT05538156Not applicable
- Comparison of Visual Outcomes of Pars Plana Vitrectomy With and Without Injection Clexane for Rhegmatogenous Retinal Detachment Proliferative VitreoretinopathyActive, not recruitingNCT07787377Not applicable1 country
- Intravitreal Triamcinolone and Biomarkers in Rhegmatogenous Retinal DetachmentCompletedNCT07774182Not applicable1 country
- Effects of 0.1% Nepafenac on Vitreous Inflammatory Biomarkers in Rhegmatogenous Retinal Detachment and Proliferative VitreoretinopathyCompletedNCT07162818Phase 41 country
- Methotrexate in Retinal Detachment With Proliferative VitreoretinopathyCompletedNCT07058337Not applicable1 country
- The GUARD Trial - Part 1: A Phase 3 Clinical Trial for Prevention of Proliferative VitreoretinopathyCompletedNCT04136366Phase 31 country
- Outcomes of Retinal Re-surgeries in Silicone Oil Filled EyesCompletedNCT065837981 country
- A Multi-Center Study on the Use of Rho-Kinase Inhibitor to Reduce or Prevent PVR in RRD Eyes at High Risk for PVRStatus unknownNCT05660447Phase 2/31 country
- Comparison High-density Silicone Oils in Retinal DetachmentWithdrawnNCT00403702Phase 2/31 country
- Intravitreal Infliximab for Proliferative VitreoretinopathyCompletedNCT04891991Phase 21 country
- Efficacy of 5-fluorouracil and Low Molecular Weight Heparin in High-risk Pediatric Retinal DetachmentCompletedNCT06166914Not applicable1 country
- Adrenocorticotropic Hormone (ACTH) for Post-op Inflammation in Proliferative Vitreoretinopathy (PVR)CompletedNCT03727776Early Phase 11 country
- Methotrexate For The Prevention and Treatment of Proliferative Vitreoretinopathy in Pediatric PatientsWithdrawnNCT04830878Phase 11 country
- Retinal Redetachment After Silicone Oil Removal : a Risk Factor AnalysisCompletedNCT056479281 country
- Air Versus Gas Tamponade in Primary Retinal DetachmentStatus unknownNCT05561569Not applicable1 country
- Ozurdex in Reducing PVR After Vitreotomy in PDRStatus unknownNCT05415826Not applicable
- Intravitreal Aflibercept for the Prevention of Proliferative Vitreoretinopathy Following Retinal Detachment RepairStatus unknownNCT04580147Phase 21 country
- Prophylactic Intravitreal 5-Fluorouracil and Heparin to Prevent PVR in High-risk Patients With Retinal Detachment.CompletedNCT02834559Phase 31 country
- Bevacizumab Against Recurrent Retinal DetachmentCompletedNCT02192970Phase 21 country
- Molecular Taxonomy of Surgically-harvested Ocular Tissues Defined by Single-cell TranscriptomicsStatus unknownNCT04682054Not applicable1 country
- Outcomes of Extensive Brilliant Blue G-Assisted Internal Limiting Membrane Peeling in Proliferative VitreoretinopathyCompletedNCT044908761 country
- Repeated Methotrexate for Proliferative Vitreoretinopathy Grade CStatus unknownNCT04482543Phase 2/31 country
- Isotretinoin for Proliferative VitreoretinopathyCompletedNCT01445028Phase 41 country
- Eye Injections of Bevacizumab for Lowering Risk of Scar Tissue in the Retina and Repeated Retinal Detachment.CompletedNCT01860586Not applicable1 country
- Postoperative Pain Control Following Vitreoretinal SurgeryCompletedNCT01995045Phase 41 country
- Optical Coherence Tomography - Rescan During Dissection of Macular MembranesStatus unknownNCT02748421Not applicable
- Comparative Study of 1000 Centistoke Versus 5000 Centistoke Silicone Oil for Repair of Complex Retinal DetachmentsCompletedNCT01255293Not applicable1 country
- Oral Colchicine Combined With Intravitreal Infusion of Dexamethasone, LMW Heparin and 5-FU for Management of Proliferative Vitreoretinopathy (PVR)Status unknownNCT00370760Phase 31 country
- Surgical Management of Pseudophakic and Aphakic Retinal Detachment; a Randomized Clinical TrialStatus unknownNCT00370279Phase 31 country
- The Effect of 5-FU and LMW Heparin on the Rate of Retinal Redetachment After Silicone Oil Removal in Cases of PVRStatus unknownNCT00371020Phase 31 country
- Triamcinolone Acetonide in Silicone-Filled Eyes as Adjunctive Treatment for Proliferative VitreoretinopathyCompletedNCT00373282Phase 31 country
- Efficacy of Oral Colchicine in Prevention of Proliferative Vitreoretinopathy in Rhegmatogenous Retinal DetachmentStatus unknownNCT00370201Phase 31 country
- The Silicone StudyCompletedNCT00000140Phase 3