Sick Sinus Syndrome clinical trials
The registry lists 93 studies for Sick Sinus Syndrome across more than 10 countries. 18 are recruiting or about to start. 57 of them are mainly about Sick Sinus Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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· Enrollment: 300 → 450 participants
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Who runs them
Abbott Medical Devices (11) · Medtronic Cardiac Rhythm and Heart Failure (7) · Boston Scientific Corporation (5) · Biotronik SE & Co. KG (4) · Medtronic BRC (4) · LivaNova (3) · Tongji Hospital (2) · China National Center for Cardiovascular Diseases (2)
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Jun 2027Predicting Severe Cardiac Arrhythmias in the Perioperative Period Using AI-ECG · I.M. Sechenov First Moscow State Medical University
- Jul 2027LEAP 2 Chronic EFS · Abbott Medical Devices
- Sep 2027Transjugular Approach for Implantation of Active Fixation Leadless Pacemakers · Min Shen
Who these studies take
Of the 12 Sick Sinus Syndrome studies recruiting now, 6 (50%) set no upper age limit and 4 (33%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (8%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 11 (92%) | 11 (92%) |
| 30 | 11 (92%) | 11 (92%) |
| 40 | 11 (92%) | 11 (92%) |
| 50 | 11 (92%) | 11 (92%) |
| 65 | 9 (75%) | 9 (75%) |
| 75 | 8 (67%) | 8 (67%) |
| 85 | 8 (67%) | 8 (67%) |
Across all 93 studies, recruiting or not: 11% stop at 75 or younger and 5% at 65; 9% take children; 0% are for women only and 0% for men only; 2% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Sick Sinus Syndrome studies take
Of 22 interventional studies with no phase under Sick Sinus Syndrome, half reached primary completion within 24 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 24 mo15–47 · 22 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Transjugular Approach for Implantation of Active Fixation Leadless PacemakersNov 10, 2026NCT07802119
Newly registered2
- Multimodality Location Prediction Accuracy of Leadless Pacemaker PositioningNov 2, 2026NCT07908927
- Belgo-Luxembourg Leadless PM RegistryOct 19, 2026NCT07879716
Studies
Recruiting first, then most recently updated. Showing 50 of 93. Browse all 93 → or search them.
- Transjugular Approach for Implantation of Active Fixation Leadless PacemakersRecruitingNCT07802119Not applicable1 country
- Multimodality Location Prediction Accuracy of Leadless Pacemaker PositioningRecruitingNCT07908927Not applicable1 country
- Belgo-Luxembourg Leadless PM RegistryNot yet recruitingNCT07879716Not applicable2 countries
- LEAP 2 Chronic EFSRecruitingNCT07287423Not applicable1 country
- Biospecimen Repository for Cardiac Arrhythmias at the Cleveland ClinicRecruitingNCT009219861 country
- Procedural Endpoint in Left Bundle Branch Area Pacing: Conduction System Capture Versus LV Septal CaptureNot yet recruitingNCT07804394Not applicable
- Prospective Cohort Study of Bachmann Bundle Versus Right Atrial Appendage Pacing: Impact on Atrial Cardiomyopathy Evaluated by Echocardiographic Parameters and Clinical OutcomeRecruitingNCT073600671 country
- BIO|STREAM.CSP CLSRecruitingNCT076088225 countries
- Comparison of Focal Cryoablation vs. Radiofrequency Cardioneuroablation for BradyarrhythmiasRecruitingNCT07671898Not applicable1 country
- Predicting Severe Cardiac Arrhythmias in the Perioperative Period Using AI-ECGNot yet recruitingNCT07348991
- Taiwan Registry for Leadless PacemakerEnrolling by invitationNCT049267921 country
- Left Bundle Branch Versus Minimized Ventricular Pacing in Patients With Sick Sinus Syndrome and Prolonged AV IntervalRecruitingNCT07314008Not applicable1 country
- PACE-AF: Prospective Analysis of Cardiac Electrostimulation and Atrial FibrillationNot yet recruitingNCT072792071 country
- Physiological Ventricular Pacing Vs Managed Ventricular Pacing for Persistent AF Prevention in Prolonged AV IntervalRecruitingNCT05367037Not applicable1 country
- AVEIR™ Leadless Pacemaker Registry in Europe and MIddle East Region (PREMIER LEADLESS)Not yet recruitingNCT06782152
- Evaluating the Safety and Effectiveness of 5G Cloud Follow-up for Cardiovascular Implantable Electronic DevicesRecruitingNCT06652750Not applicable1 country
- Cardioneuroablation for BradyarrhythmiaRecruitingNCT06288633Not applicable1 country
- Cardiac Denervation Ablation Strategy for Severe Sinus BradycardiaRecruitingNCT062768161 country
- Safety, Performance, and Clinical Benefit of Pacing the Left Bundle Branch Area - Post-Market Clinical Follow-upActive, not recruitingNCT072098527 countries
- BIOTRONIK Conduction System Pacing With the Solia Lead - Solia CSP SCompletedNCT06540079Not applicable1 country
- Aveir DR i2i StudyCompletedNCT05252702Not applicable13 countries
- AV Delay Optimization vs. Intrinsic Conduction in Pacemaker Patients With Long PR IntervalsCompletedNCT02154750Not applicable1 country
- Effect of Paced HR on Central BPCompletedNCT07078487Not applicable1 country
- Atrial Synchrony Evaluation of Bachmann Bundle Pacing in Sick Sinus SyndromeCompletedNCT07055035Not applicable1 country
- PANORAMA Observational StudyCompletedNCT003825256 countries
- EnTRINSIC - EnPulse Trial on Search AV+ InfluenceTerminatedNCT00157794Phase 41 country
- DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients.CompletedNCT00478933Not applicable
- The Fluoroless-CSP Trial Using Electroanatomic MappingCompletedNCT03903107Not applicable1 country
- Allometric-Pace StudyCompletedNCT057664621 country
- LBBAP Data Collection RegistryCompletedNCT058873235 countries
- Suture Closure AFtEr VEIN Access for Cardiac Procedures (SAFE-VEIN) TrialCompletedNCT04632641Not applicable1 country
- Physiologic Pacing RegistryCompletedNCT0371904016 countries
- Ingenio Device Algorithm StudyCompletedNCT01441583Not applicable12 countries
- Reducing Atrial Pacing Rate to Reduce Atrial Fibrillation in Patients With Sick Sinus Syndrome.CompletedNCT02034526Not applicable1 country
- Clinical Benefits of the Closed Loop Stimulation in Sinus Node DiseaseTerminatedNCT02579889Not applicable9 countries
- Evaluation of Ventricular Pacing Suppression Algorithms in Dual Chamber PacemakerCompletedNCT03843242Not applicable1 country
- Left Ventricular Pacing to Avoid Cardiac Enlargement StudyWithdrawnNCT01302717Not applicable1 country
- Permanent Pacemaker Implantation or Cardioneuroablation in Sinus Node DysfunctionStatus unknownNCT05196126Not applicable1 country
- Specialized Pacing for Patients With Congenital Heart DiseaseTerminatedNCT03361189Phase 2/31 country
- Pulmonary Artery Pressure and Right Heart Evaluation for Patients Requiring Physiological Pacing TreatmentStatus unknownNCT05575557Not applicable1 country
- Left Bundle Area Versus Selective His Bundle PacingTerminatedNCT04093414Not applicable1 country
- Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections.CompletedNCT02809131Phase 31 country
- Cardioneuroablation Versus Pacemaker Implantation for the Treatment of Symptomatic Sinus Node DysfunctionStatus unknownNCT05186220Not applicable1 country
- Registry to Improve the Adoption of Consensus Treatment Guidelines (IMPROVE Brady)CompletedNCT016437077 countries
- Beluga - Clinical Observations of Automatic Algorithms for Cardiac PacingCompletedNCT002868582 countries
- Second Study on Cardio-neuromodulation in HumansCompletedNCT02954666Not applicable1 country
- Right Ventricle (RV) Markers of Future Pacing Induced Ventricular Dysfunction - PilotCompletedNCT021987811 country
- HBP Device EGM Data CollectionCompletedNCT035648601 country
- Impact of Septal Vs Apical Pacing on Right and Left Ventricular PerformanceTerminatedNCT01798043Not applicable1 country
- Long-term Atrial Pacing and Central Blood PressureStatus unknownNCT04309175Not applicable