LivaNova clinical trials

The registry lists 75 studies whose lead sponsor is LivaNova or one of 5 companies grouped under it. 2 are recruiting or about to start. Per ClinicalTrials.gov, last updated Oct 21, 2026.

Studies

Recruiting first, then most recently updated. Showing 50 of 75. Browse all 75 →

• A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant DepressionRecruitingNCT03887715Not applicable
• A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression.RecruitingNCT03320304
• Treating Obstructive Sleep Apnea Using Targeted Hypoglossal NeurostimulationCompletedNCT04950894Not applicable
• Non-interventional Study Describing Healthcare Resource Utilisation and Clinical Outcomes Associated With VNS Therapy in UK.TerminatedNCT04779814
• The RECOVER sUb-study, Which Leverages quaNtitative and Credible Research tOols From Verily, Will providE Assessment measuRes for Depressive EpisodesTerminatedNCT04753385
• IMPACT of AspireSR® for VNS Therapy on Healthcare Resource Utilisation and Clinical Outcomes.TerminatedNCT05975931
• Registry of Subjects With Drug Resistant Epilepsy and Treated With the VNS Therapy System.CompletedNCT03529045
• Targeted Hypoglossal Neurostimulation Study #3CompletedNCT02263859Not applicable

  Sponsor listed in the registry: ImThera Medical, Inc. · First submitted before ImThera Medical, Inc. became part of LivaNova

• ANTHEM-HFrEF Pivotal StudyTerminatedNCT03425422Not applicable
• TandemHeart Experiences and MEthods (THEME Registry)TerminatedNCT02326402

  Sponsor listed in the registry: CardiacAssist, Inc. · First submitted before CardiacAssist, Inc. became part of LivaNova

• Autonomic Regulation Therapy in Heart Failure With Preserved Ejection FractionCompletedNCT03163030Not applicable

  Sponsor listed in the registry: Cyberonics, Inc. · First submitted after Cyberonics, Inc. became part of LivaNova

• Microburst Vagus Nerve Stimulator (VNS) Therapy Feasibility StudyCompletedNCT03446664Not applicable
• XLTCS - Accelerometer Data Collection in an Epilepsy Monitoring Unit (EMU)WithdrawnNCT04282681
• Study to Evaluate a New Device Designed to Collect Heart Activity and Body Movement DataCompletedNCT01626599Not applicable

  Sponsor listed in the registry: Cyberonics, Inc. · First submitted before Cyberonics, Inc. became part of LivaNova

• Mitroflow DL Post Approval Study- North AmericaTerminatedNCT02351726Not applicable
• Caisson Transcatheter Mitral Valve Replacement (TMVR) System Early Feasibility StudyStatus unknownNCT02768402Not applicable

  Sponsor listed in the registry: Caisson Interventional LLC · First submitted before Caisson Interventional LLC became part of LivaNova

• Caisson Transcatheter Mitral Valve Replacement (TMVR)Active, not recruitingNCT03661398Not applicable

  Sponsor listed in the registry: Caisson Interventional LLC · First submitted after Caisson Interventional LLC became part of LivaNova

• Vagus Nerve Stimulation Clinical Outcomes Measured Prospectively in Patients StimulatedCompletedNCT01281293

  Sponsor listed in the registry: Cyberonics, Inc. · First submitted before Cyberonics, Inc. became part of LivaNova

• Safety and Efficacy of a Hypoglossal Nerve Implant for the Treatment of Obstructive Sleep Apnea (OSA)CompletedNCT01532180Not applicable

  Sponsor listed in the registry: ImThera Medical, Inc. · First submitted before ImThera Medical, Inc. became part of LivaNova

• Targeted Hypoglossal Neurostimulation Study #2CompletedNCT01796925Not applicable

  Sponsor listed in the registry: ImThera Medical, Inc. · First submitted before ImThera Medical, Inc. became part of LivaNova

• Clinical Evaluation of LEft VEntricular Auto Threshold Algorithm (LEVEA)CompletedNCT03014180Not applicable
• Vagus Nerve Stimulation Titration Protocol to Improve Tolerance and Accelerate AdaptationCompletedNCT02385526

  Sponsor listed in the registry: Cyberonics, Inc. · First submitted before Cyberonics, Inc. became part of LivaNova

• Clinical Evaluation Of The Nano Lv Lead System In Chronic Situation (LENEA)TerminatedNCT01731210Phase 2/3
• VAgal Nerve Stimulation: safeGUARDing Heart Failure PatientsCompletedNCT02113033Phase 2
• Natural Evolution of AV Conduction Disorders in Patients Implanted With Cardiac PacemakersCompletedNCT00531037
• Sleep Apnea, Arrhythmias and Cardiac Reverse Remodeling in Heart Failure PatientsWithdrawnNCT02870647Phase 4
• Optimization With SonR Method in the ClinicAl pRacticeCompletedNCT02250547
• Evolution of the PR Interval in Patients Implanted With a Pacemaker Using the SafeR ModeCompletedNCT02586480
• PErsonalized and Adaptive Kinesthetic stImulation Therapy, Based on Cardio-respiratory Holter moNitoring, for Sleep Apnea syndrOmesCompletedNCT02789748Not applicable
• HYpopnea and Apnea Detection and Treatment Performance of a New cardiOreSpiratory Holter MonitorCompletedNCT03300037
• Left Ventricular Pacing Vectors Effectiveness to Narrow Phrenic Nerve StimulationCompletedNCT03127202Not applicable
• The remedē® System for the Treatment of Central Sleep Apnea in Daily PracticeTerminatedNCT02577445
• VITARIA Registry StudySuspendedNCT02545582

  Sponsor listed in the registry: Cyberonics, Inc. · First submitted before Cyberonics, Inc. became part of LivaNova

• Perceval S Aortic Heart Valve Study- North AmericaTerminatedNCT01810679Not applicable

  Sponsor listed in the registry: Sorin Group USA, Inc. · First submitted before Sorin Group USA, Inc. became part of LivaNova

• Seizure Detection and Automatic Magnet Mode Performance StudyCompletedNCT01325623Not applicable

  Sponsor listed in the registry: Cyberonics, Inc. · First submitted before Cyberonics, Inc. became part of LivaNova

• Treatment-Resistant Depression RegistryCompletedNCT00320372

  Sponsor listed in the registry: Cyberonics, Inc. · First submitted before Cyberonics, Inc. became part of LivaNova

• TandemHeart to Reduce Infarct Size (TRIS Trial)WithdrawnNCT02164058Not applicable

  Sponsor listed in the registry: CardiacAssist, Inc. · First submitted before CardiacAssist, Inc. became part of LivaNova

• Impact of Ventricular Pacing in Unselected ICD/CRT-D PatientsCompletedNCT01169896
• VNS Therapy Automatic Magnet Mode Outcomes Study in Epilepsy Patients Exhibiting Ictal Tachycardia (E-37)CompletedNCT01846741Not applicable

  Sponsor listed in the registry: Cyberonics, Inc. · First submitted before Cyberonics, Inc. became part of LivaNova

• Autonomic Neural Regulation Therapy to Enhance Myocardial Function in Heart Failure (ANTHEM-HF) StudyCompletedNCT01823887Phase 1/2

  Sponsor listed in the registry: Cyberonics, Inc. · First submitted before Cyberonics, Inc. became part of LivaNova

• Freedom SOLO Stentless Heart Valve StudyCompletedNCT01115907Phase 3

  Sponsor listed in the registry: Sorin Group USA, Inc. · First submitted before Sorin Group USA, Inc. became part of LivaNova

• Study Comparing Best Medical Practice With or Without VNS Therapy in Pharmacoresistant Partial Epilepsy PatientsTerminatedNCT00522418Phase 4

  Sponsor listed in the registry: Cyberonics, Inc. · First submitted before Cyberonics, Inc. became part of LivaNova

• Safety and Efficacy Study of the Sorin 3D Annuloplasty Ring For Mitral RepairCompletedNCT00567853Phase 3

  Sponsor listed in the registry: Sorin Group USA, Inc. · First submitted before Sorin Group USA, Inc. became part of LivaNova

• Optimal Anti-tachycardia Therapy in Implantable Cardioverter-defibrillator (ICD) Patients Without Pacing IndicationsCompletedNCT00729703Phase 4
• Predictive Risk Stratification Through T Variability in ICD Patients Without Pacing IndicationsCompletedNCT00560768Phase 4
• Clinical Status Monitoring in Implantable Cardiac Defibrillator (ICD) Patients by Physiological Diagnosis (PhD) FunctionTerminatedNCT01170624Phase 4
• PuLsE 2-Observational Long-Term Effectiveness Follow-Up Study of PuLsE 1CompletedNCT01281280

  Sponsor listed in the registry: Cyberonics, Inc. · First submitted before Cyberonics, Inc. became part of LivaNova

• Monitoring of Syncopes and/or Sustained Palpitations of Suspected Arrhythmic Origin With External Loop-Recorder (SpiderFLASH)CompletedNCT02253134
• An Observational Study on the Sorin Group New Brady Leads XFine and BeflexCompletedNCT01168518
• Evaluation of the SafeR Mode in Patients With a Dual Chamber Pacemaker IndicationCompletedNCT00562107Phase 4