Rickets clinical trials
The registry lists 36 studies for Rickets across more than 10 countries. 2 are recruiting or about to start. 11 of them are mainly about Rickets (how this is decided). Per ClinicalTrials.gov, last updated 2026-05-27. Counting its 4 narrower conditions too, such as Chronic Kidney Disease-Mineral and Bone Disorder: 173 studies, 31 open.
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Who runs them
Alexion Pharmaceuticals, Inc. (13) · Mayo Clinic (4) · Yale University (3) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2) · University College, London (1) · McGill University (1) · Boston Children's Hospital (1) · National Institute of Dental and Craniofacial Research (NIDCR) (1)
What is being tested here
Drugs under test in Rickets studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Phosphates | 1 | 0 | 1 |
| Asfotase alfa | 0 | 1 | 9 |
| Calcitriol | 0 | 0 | 2 |
| Ergocalciferols | 0 | 0 | 2 |
| Vitamin D | 0 | 0 | 2 |
| Cholecalciferol | 0 | 1 | 2 |
| Burosumab | 0 | 0 | 1 |
| Ascorbic Acid | 0 | 1 | 1 |
| Paricalcitol | 0 | 1 | 1 |
| Iron | 0 | 0 | 1 |
Who these studies take
Of the 2 Rickets studies recruiting now, 1 (50%) set no upper age limit and 1 (50%) stop at 75 or younger. 2 (100%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (50%) | 1 (50%) |
| 18 | 2 (100%) | 2 (100%) |
| 30 | 1 (50%) | 1 (50%) |
| 40 | 1 (50%) | 1 (50%) |
| 50 | 1 (50%) | 1 (50%) |
| 65 | 1 (50%) | 1 (50%) |
| 75 | 1 (50%) | 1 (50%) |
| 85 | 1 (50%) | 1 (50%) |
Across all 36 studies, recruiting or not: 58% stop at 75 or younger and 56% at 65; 92% take children; 6% are for women only and 0% for men only; 33% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 36 of 36. search them.
- The Impact of Phosphate Metabolism on Healthy AgingRecruitingNCT03771105Early Phase 11 country
- Effective Dosing of Burosumab in XLHRecruitingNCT071835791 country
- Calcitriol Monotherapy for X-Linked HypophosphatemiaCompletedNCT03748966Early Phase 11 country
- Specturi Device - Feasibility StudyCompletedNCT031055571 country
- Burosumab for Fibroblast Growth Factor-23 Mediated Hypophosphatemia in Fibrous DysplasiaCompletedNCT05509595Phase 21 country
- A Study to Assess Metabolic Bone Disease of Prematurity Using an Acoustic MethodCompletedNCT04752098Not applicable1 country
- Ultrasound Imaging and Quantitative Vibro-Acoustic Assessment of Rickets Under the Age of TenWithdrawnNCT06385938
- Safety and Efficacy Study of ENB-0040 in Juvenile Patients With Hypophosphatasia (HPP)WithdrawnNCT00894075Phase 2
- Effectiveness of Vitamin C Supplementation in Treatment of RicketsCompletedNCT05310760Phase 2/31 country
- Studies of States With Resistance to Vitamin D and Parathyroid HormoneCompletedNCT000012421 country
- Development of a Non-invasive Assessment of Human Bone Quality Using Spatially Offset Raman SpectroscopyActive, not recruitingNCT02814591
- Pilot Study: The Effect of Ergocalciferol on Plasma Mucin-1 LevelsCompletedNCT03747523Early Phase 11 country
- Effectiveness of Paricalcitol in Reducing Parathyroid Hormone (PTH) Levels in X-linked Hypophosphatemic RicketsCompletedNCT00417612Phase 31 country
- Iron Therapy for Autosomal Dominant Hypophosphatemic Rickets: A Pilot Project.CompletedNCT02233322Not applicable1 country
- Retrospective, Non-interventional Natural History of Patients With Juvenile-onset Hypophosphatasia (HPP)CompletedNCT021042198 countries
- Safety and Efficacy of Asfotase Alfa in Juvenile Patients With Hypophosphatasia (HPP)CompletedNCT00952484Phase 22 countries
- Safety and Efficacy Study of Asfotase Alfa in Severely Affected Infants With Hypophosphatasia (HPP)CompletedNCT00744042Phase 1/24 countries
- A Retrospective Study of the Natural History of Patients With Severe Perinatal and Infantile Hypophosphatasia (HPP)CompletedNCT014190287 countries
- Safety Study of Human Recombinant Tissue Non-Specific Alkaline Phosphatase Fusion Protein Asfotase Alfa in Adults With Hypophosphatasia (HPP)CompletedNCT00739505Phase 12 countries
- Expanded Access Program for Asfotase Alfa Treatment for Patients With Infantile- or Juvenile-onset Hypophosphatasia (HPP)Approved for marketingNCT024966892 countries
- Extension Study of Protocol ENB-006-09 - Study of Asfotase Alfa in Children With Hypophosphatasia (HPP)CompletedNCT01203826Phase 22 countries
- Extension Study of Protocol ENB-002-08 - Study of Asfotase Alfa in Infants and Young Children With Hypophosphatasia (HPP)CompletedNCT01205152Phase 23 countries
- Non-interventional Substudy of ALX-HPP-502 to Assess Natural History of Patients With Juvenile-onset HPP Who Served as Historical Controls in ENB-006-09CompletedNCT022354931 country
- Safety and Efficacy Study of Asfotase Alfa in Adolescents and Adults With Hypophosphatasia (HPP)CompletedNCT01163149Phase 22 countries
- Open-Label Study of Asfotase Alfa in Infants and Children ≤ 5 Years of Age With Hypophosphatasia (HPP)CompletedNCT01176266Phase 2/312 countries
- Post-approval Clinical Study of Asfotase Alfa Treatment for Patients With Hypophosphatasia (HPP) in JapanCompletedNCT02531867Phase 4
- Hypophosphatemic Rickets in NorwayStatus unknownNCT010571861 country
- Maternal and Infant Vitamin Status During the First Nine Months of Infant LifeCompletedNCT025485201 country
- Vitamin D, Iodine, and Lead Levels in Haitian Infants and Children.CompletedNCT023015201 country
- Effects of Vitamin D Dose and Genotype of the Binding Protein in Infants and ChildrenCompletedNCT01050387Not applicable1 country
- Study to Assess the Use of a Simple Lab Test to Screen for Rickets in ChildrenCompletedNCT005028661 country
- Studies With 1,25-DihydroxycholecalciferolTerminatedNCT00001151Phase 21 country
- Assessment Of Vitamin D Role In The Pathogenesis Of Asthma In Vitamin D Resistent PatientsCompletedNCT01578824Not applicable1 country
- Vitamin D Supplementation in Breastfeeding WomenCompletedNCT01240265Phase 2/31 country
- Vitamin D and Genetics in Nutritional RicketsCompletedNCT00949832Phase 41 country
- Study Comparing Two Isoforms of Vitamin D Supplements for InfantsCompletedNCT01190137Phase 31 country