An observational study in Rickets, sponsored by Mayo Clinic. Withdrawn. Open to participants aged Up to 10 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-12-16.
Sponsored by Mayo Clinic · Observational
The goal of this study is to find out if the use of ultrasound pictures of bones can spot changes in the growth areas of children with rickets, a condition that affects how bones harden. Researchers want to see if these ultrasound pictures can help tell the difference between children who have rickets and those who don't.
Aims, purpose, or objectives:
36 studies on the registry are indexed under Rickets; 2 are open to participants now.
Browse Rickets studies →Mayo Clinic is the lead sponsor of 3,269 studies on the registry; 672 are open to participants now.
Of its 452 completed or terminated interventional studies of FDA-regulated products, 321 (71%) have results posted.
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Prepubertal children \<10 years of age at enrollment with active nutritional or genetic rickets recruited from the Mayo Clinic Pediatric Endocrinology Bone Clinic or from the Mayo Clinic outpatient or inpatient services in Rochester, MN (cases). Healthy matched control children will be recruited from children empaneled in Mayo Clinic primary care (Family Medicine or Community Pediatrics).
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Children under 10 years of age with a diagnosis of active rickets on radiographs of the wrists and knees will undergo ultrasound imaging and quantitative vibro-acoustic assessment.
Diagnostic Test: Ultrasound with quantitative vibro-acoustic assessment
Healthy children under 10 years of age not diagnosed with rickets, but match the age, gender, and weight of the children with rickets, will undergo ultrasound imaging and quantitative vibro-acoustic assessment.
Diagnostic Test: Ultrasound with quantitative vibro-acoustic assessment
Imaging with non-invasive bone assessment based on wide range of frequencies and free from soft tissue artifact of the wrists and the knees
Relationship of quantitative vibro-acoustic ultrasound and rickets severity score
Quantitative vibro-acoustic data will be compared with the radiographic rickets severity score to assess if ultrasound measures are reliably related to the radiographic findings.
Time frame: Baseline
Relationship of ultrasound images with radiographic evidence of rickets
Determine if ultrasound imaging of bone can identify the changes of impaired mineralization of the growth plates at the wrists and the knees, similar to those visible on plain radiographs
Time frame: Baseline
Case-control comparison of quantitative vibro-acoustic ultrasound measurements between children with rickets and control subjects
2. To determine if quantitative vibro-acoustic measurements of the bone in subjects with rickets significantly differs from control subjects, matched for age, sex, and BMI.
Time frame: Baseline
Longitudinal changes in vibro-acoustic ultrasound measurements with treatment of rickets
To determine if longitudinal changes in ultrasound images and quantitative vibro-acoustic assessment with treatment of rickets are related to changes in the rickets severity score
Time frame: Baseline
No study locations are listed for this record.
Plan to share: No
Ran from Mar 2024 to primary completion in Dec 2024, 8 months.
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This study is withdrawn, as verified in Dec 2024. You cannot join it, but the record below documents what was studied.
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