Rhinosinusitis clinical trials
The registry lists 251 studies for Rhinosinusitis across more than 10 countries. 69 are recruiting or about to start. 146 of them are mainly about Rhinosinusitis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Status
Who runs them
Sanofi (11) · Cairo University (6) · Keymed Biosciences Co.Ltd (5) · AstraZeneca (5) · Beijing Tongren Hospital (5) · Washington University School of Medicine (4) · Centre hospitalier de l'Université de Montréal (CHUM) (4) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (3)
What is being tested here
Drugs under test in Rhinosinusitis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Budesonide | 1 | 0 | 4 |
| MMH-407 | 1 | 1 | 1 |
| Sodium Chloride | 0 | 0 | 2 |
| Tezepelumab | 0 | 1 | 1 |
| Dexmedetomidine | 0 | 0 | 1 |
| Saline Solution | 0 | 0 | 1 |
| Xylitol | 0 | 1 | 1 |
| Acetylcysteine | 0 | 1 | 1 |
| Dexpramipexole | 0 | 0 | 1 |
| Silver | 0 | 0 | 1 |
Drug classes tested here Corticosteroids 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jan 2027A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab · Phase 3 · AstraZeneca
- Feb 2027An Extension Study to Investigate the Long-term Safety and Tolerability of Itepekimab in Adult Participants With Inadequately Controlled Chronic Rhinosinusitis With Nasal Polyps · Phase 3 · Sanofi
- Mar 2027Clinical Trial of TQC2731 Injection in Patients With Chronic Sinusitis and Nasal Polyps · Phase 3 · Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd.
- May 2027A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP) · Phase 3 · Eli Lilly and Company
- Oct 2027Using Navigation to Improve Accuracy of Maxillary Balloon Sinusotomy · Phase 3 · Cedars-Sinai Medical Center
- Nov 2027A Study of CM512 in Patients With Chronic Rhinosinusitis With Nasal Polyposis (NEZHA-3) · Phase 3 · Beijing Keymed Biosciences Co., Ltd.
- Nov 2026Performance and Safety Assessment of the Mechanical Decongestant Seawater Spray Enriched With Essential Oils From Laboratoires Gilbert in Patient With Acute Rhinitis Associated With Nasal Obstruction · Laboratoires Gilbert
- Dec 2026Nasal Potential Difference (NPD) Protocol in Chronic Rhinosinusitis · University of Alabama at Birmingham
- Dec 2026Safety and Performance Assessment of the Decongestant Seawater Spray Pocket Valve Enriched With Essential Oils in Patients With Acute Rhinitis Associated With Nasal Obstruction: "DEVALPO" · Laboratoires Gilbert
- Dec 2026Mepolizumab and in Office-office Nasal Polypectomy in Patients With Chronic Rhinosinusitis (CRS). · Instituto de Investigación Marqués de Valdecilla
Who these studies take
Of the 33 Rhinosinusitis studies recruiting now, 14 (42%) set no upper age limit and 13 (39%) stop at 75 or younger. 4 (12%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 6 (18%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 30 (91%) | 30 (91%) |
| 30 | 32 (97%) | 32 (97%) |
| 40 | 32 (97%) | 32 (97%) |
| 50 | 32 (97%) | 32 (97%) |
| 65 | 29 (88%) | 29 (88%) |
| 75 | 24 (73%) | 24 (73%) |
| 85 | 18 (55%) | 18 (55%) |
Across all 251 studies, recruiting or not: 43% stop at 75 or younger and 20% at 65; 16% take children; 0% are for women only and <1% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Rhinosinusitis studies take
Of 24 phase 3 interventional studies under Rhinosinusitis, half reached primary completion within 22 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 18 mo13–26 · 16 studies | — | — |
| Phase 3 | 22 mo19–37 · 24 studies | — | — |
| Phase 4 | 33 mo14–35 · 14 studies | — | — |
| Interventional, no phase | 16 mo6–36 · 33 studies | — | — |
| Observational | 27 mo15–71 · 22 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 251. Browse all 251 → or search them.
- Tezepelumab CRSwNP Real World Study (CREW Study)Not yet recruitingNCT077901981 country
- A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)RecruitingNCT06338995Phase 320 countries
- A Study to Evaluate the Efficacy and Safety of MG-K10 in Adults With Chronic Rhinosinusitis With Nasal PolypsNot yet recruitingNCT07903194Phase 3
- Paclitaxel-Coated Balloon Treatment of Chronic RhinosinusitisRecruitingNCT07290140Not applicable1 country
- Prospective, Non-interventional Single-arm Study With Tezepelumab to Investigate the Change in Clinical and Patient-reported Outcomes in Patients With CRSwNP in Real-world (PETRICHOR)RecruitingNCT076331581 country
- A Study to Investigate NPS and Symptoms in Chinese Adult Participants With CRSwNP Initiating Treatment With TezepelumabRecruitingNCT07520162Phase 31 country
- Post-market Clinical Follow-up Study of an Isotonic Saline Solution for the Relief of Nasal Congestion in Infants and ToddlersNot yet recruitingNCT072572241 country
- Longitudinal Deep Phenotyping of Central Mechanisms in Dysosmia: A Pilot Study Using Electrobulbogram (EBG), Functional MRI (fMRI), and Diffusion-Weighted Imaging (DWI)RecruitingNCT071494281 country
- Efficacy and Safety of 186 mcg of OPN-375 Nasal Spray Twice a Day (BID) in Adolescents With Chronic Rhinosinusitis Without Nasal PolypsRecruitingNCT06850805Phase 31 country
- Position-Directed Budesonide Nasal Drops for CRS-associated Olfactory DysfunctionNot yet recruitingNCT07386873Not applicable1 country
- Neural Dissimilarity in Patients With Chronic Rhinosinusitis With Nasal Polyps Treated With BiologicsNot yet recruitingNCT078191621 country
- Mepolizumab and in Office-office Nasal Polypectomy in Patients With Chronic Rhinosinusitis (CRS).RecruitingNCT07814924Phase 41 country
- CRS Questionnaire Validation ProjectRecruitingNCT0697097711 countries
- A Study of CM512 in Patients With Chronic Rhinosinusitis With Nasal Polyposis (NEZHA-3)Not yet recruitingNCT07807826Phase 31 country
- Bactorinol® Nasal Spray With Reduced-Dose Mometasone in Adults With Chronic RhinosinusitisNot yet recruitingNCT07800273Not applicable1 country
- Pistacia Lentiscus Oil Nasal Spray With Reduced-Dose Mometasone in Chronic RhinosinusitisNot yet recruitingNCT07787494Not applicable1 country
- Safety and Performance Assessment of the Decongestant Seawater Spray Pocket Valve Enriched With Essential Oils in Patients With Acute Rhinitis Associated With Nasal Obstruction: "DEVALPO"RecruitingNCT05494346Not applicable1 country
- Performance and Safety Assessment of the Mechanical Decongestant Seawater Spray Enriched With Essential Oils From Laboratoires Gilbert in Patient With Acute Rhinitis Associated With Nasal ObstructionRecruitingNCT065802101 country
- Effect of Post Operative Low Dose Oral Azithromycin in Chronic Rhinosinusitis Patients With Nasal PolypsNot yet recruitingNCT07780292Phase 4
- A Study to Evaluate the Efficacy and Safety of AK139 in Participants With Chronic Rhinosinusitis With Nasal PolypsNot yet recruitingNCT07755371Phase 21 country
- Efficacy of Bee Venom Phonophoresis in Treating Chronic Sinusitis:Not yet recruitingNCT07151313Not applicable1 country
- A Study of BBT002 in Healthy Volunteers (HVs) and in Patients With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) With or Without Comorbid AsthmaRecruitingNCT07436949Phase 1/21 country
- A Study of CM512 in Patients With Chronic Rhinosinusitis With Nasal Polyposis (NEZHA-2)Not yet recruitingNCT07519577Phase 21 country
- Evaluation of the Safety and Performance of a Bioresorbable Nasal Dressing Containing Mometasone Furoate (MF)Enrolling by invitationNCT07286201Not applicable1 country
- RhinAV_Evaluation of Treatments for Acute Viral Rhinitis, Rhinosinusitis, and RhinopharyngitisRecruitingNCT07383493Not applicable1 country
- Thermosensitive Gel Nasal Spray With Exosomes, Azelastine, and Interferon for Acute Phase of Chronic SinusitisNot yet recruitingNCT07635459Early Phase 1
- Observational Study of RHINOSEDAL in Acute Nasal ObstructionNot yet recruitingNCT076205221 country
- 3D Printing to Improve Nasal Irrigation OutcomeRecruitingNCT06118554Not applicable1 country
- Upper Airway Inflammation and Olfaction: Mechanisms of Loss and RecoveryRecruitingNCT06776042Not applicable1 country
- Propel Drug-Eluting Sinus Implant Family IBUKI CohortRecruitingNCT075466821 country
- Efficacy and Safety of Fully Resorbable Sinus Drug-eluting Stents in Patients With Eosinophilic Chronic Rhinosinusitis With Nasal Polyps After Surgery: A Prospective, Randomized Controlled TrialRecruitingNCT07498374Not applicable1 country
- Nasal Potential Difference (NPD) Protocol in Chronic RhinosinusitisRecruitingNCT020381661 country
- The Efficacy and Safety of Raphamin in the Treatment of Acute Rhinosinusitis in Adult PatientsRecruitingNCT06901297Phase 31 country
- Using Navigation to Improve Accuracy of Maxillary Balloon SinusotomyRecruitingNCT06567821Phase 2/31 country
- A Randomized, Double-blind, Placebo-controlled Phase III Study to Evaluate the Efficacy and Safety of CM326 in Participants With Chronic Rhinosinusitis With Nasal PolyposisNot yet recruitingNCT07420257Phase 3
- A Study to Evaluate the Efficacy and Safety of LP-003 Injection in Patients With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)Not yet recruitingNCT07313917Phase 21 country
- Intra-Sinus Povidone-Iodine and Budesonide After Endoscopic Sinus Surgery for Chronic RhinosinusitisNot yet recruitingNCT07383402Phase 3
- Effect of Chinese Herbal Medicine Nasal Irrigation on the Postoperative Care of Chronic RhinosinusitisRecruitingNCT07340411Phase 21 country
- Real-Time Diagnosis of Eosinophilic Nasal Polyps Using High-Sensitivity SpectroscopyRecruitingNCT07125586Not applicable1 country
- Treatment Decision-Making Among Patients With Chronic RhinosinusitisEnrolling by invitationNCT07010679Not applicable1 country
- Nebulized Nasal SteroidsNot yet recruitingNCT07270302Phase 1/21 country
- A Phase I Study Evaluating the Safety, Tolerability, and Pharmacokinetics of VVN432 Nasal SprayRecruitingNCT07259538Phase 11 country
- Efficacy and Safety of SHR-1905 Injection in Subjects With Chronic Rhinosinusitis With Nasal PolypsRecruitingNCT07132827Phase 31 country
- Tapering of Biologics in Chronic Rhinosinusitis With Nasal PolypsRecruitingNCT07187583Phase 41 country
- Sinonasal Microbiome Transplant as a Therapy for Chronic Rhinosinusitis (CRS).RecruitingNCT07184684Phase 2/31 country
- Efficacy Of Erythromycin Phonophoresis on Chronic RhinosinusitisNot yet recruitingNCT07063082Not applicable1 country
- Effectiveness of Penthrox vs Placebo in Sinus Procedures, a Clinical TrialRecruitingNCT06750302Phase 1/21 country
- Comparative Effects of Therapeutic Ultrasound and Sinus Massage in Chronic Rhinosinusitis: a Randomized Controlled StudyRecruitingNCT06960876Not applicable1 country
- Effect of Dupilumab on Nasal Epithelial Barrier Function in Patients With CRSwNPRecruitingNCT063988731 country
- The Effect of Modified Olfactory Training on Postoperative Olfactory Dysfunction in Patients With CRSNot yet recruitingNCT06837051Not applicable1 country