Vanderbilt University Medical Center: Pure Autonomic Failure trials

The registry lists 12 Pure Autonomic Failure studies with Vanderbilt University Medical Center as lead sponsor. 5 are open to participants now and 2 have results posted.

Early Phase 1 2Phase 1 3Phase 2 2No phase 6(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• CPAP for the Treatment of Supine HypertensionRecruitingNCT05489575Not applicable
• Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension SymptomsRecruitingNCT04782830Not applicable
• Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic FailureRecruitingNCT04502225Not applicable
• Treatment of Supine Hypertension in Autonomic Failure (CPAP)RecruitingNCT03312556Not applicable
• Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine HypertensionRecruitingNCT03042988Not applicable
• Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure PatientsCompletedNCT04620382Early Phase 1Results posted
• Norepinephrine Transporter Blockade, Autonomic Failure (NETAF)CompletedNCT02784535Phase 2Results posted
• Automated Abdominal Binder for Orthostatic HypotensionCompletedNCT03482297Phase 1/2
• Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic FailureTerminatedNCT02897063Phase 1
• Blood Pressure Lowering Effects of Angiotensin-(1-7) in Primary Autonomic FailureTerminatedNCT02591173Early Phase 1
• Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic FailureCompletedNCT02429557Phase 1
• Norepinephrine Transporter Blockade as a Pathological Biomarker in Neurogenic Orthostatic HypotensionCompletedNCT01316666