Periodontal Attachment Loss clinical trials
The registry lists 52 studies for Periodontal Attachment Loss across more than 10 countries. 13 are recruiting or about to start. 12 of them are mainly about Periodontal Attachment Loss (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-04.
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Who runs them
G. d'Annunzio University (5) · Ain Shams University (2) · Universitat Internacional de Catalunya (2) · Texas A&M University (2) · University of Ljubljana (2) · National University of Singapore (2) · Brock University (2) · Queen Mary University of London (2)
What is being tested here
Drugs under test in Periodontal Attachment Loss studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Hyaluronic Acid | 1 | 0 | 1 |
| Octenidine | 1 | 0 | 1 |
| Coconut Oil | 0 | 0 | 1 |
| Trafermin | 0 | 1 | 1 |
| Omega-3 fatty acid | 0 | 0 | 1 |
| Niacinamide | 0 | 0 | 1 |
| Niacin | 0 | 0 | 1 |
| Folic Acid | 0 | 0 | 1 |
| Metronidazole | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4
- Dec 2026Hyaluronic Acid and Polynucleotides for Supra-bony Defects · Queen Mary University of London
- Dec 2026Adjunctive Diode Laser Therapy in Non-Surgical Periodontal Therapy · Tel Aviv University
- Mar 2027Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis · University of Chile
- Sep 2027Clinical Effectiveness of Biologic Agents as an Adjunct to Non-surgical Periodontal Therapy of Intrabony Defects · G. d'Annunzio University
Who these studies take
Of the 11 Periodontal Attachment Loss studies recruiting now, 8 (73%) set no upper age limit and 2 (18%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 6 (55%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 10 (91%) | 10 (91%) |
| 30 | 11 (100%) | 11 (100%) |
| 40 | 11 (100%) | 11 (100%) |
| 50 | 11 (100%) | 11 (100%) |
| 65 | 10 (91%) | 10 (91%) |
| 75 | 10 (91%) | 10 (91%) |
| 85 | 8 (73%) | 8 (73%) |
Across all 52 studies, recruiting or not: 42% stop at 75 or younger and 29% at 65; 10% take children; 4% are for women only and 0% for men only; 56% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Periodontal Attachment Loss studies take
Of 29 interventional studies with no phase under Periodontal Attachment Loss, half reached primary completion within 14 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 14 mo11–19 · 29 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Newly registered1
- Timing of Oral Hygiene Improvement Relative to Subgingival InstrumentationNov 3, 2026NCT07914400
Studies
Recruiting first, then most recently updated. Showing 50 of 52. Browse all 52 → or search them.
- Hyaluronic Acid and Polynucleotides for Supra-bony DefectsRecruitingNCT06309719Not applicable1 country
- PRF as Adjunct to Subgingival Instrumentation in Step 2 Periodontal TherapyRecruitingNCT07013682Not applicable1 country
- Clinical Effectiveness of Biologic Agents as an Adjunct to Non-surgical Periodontal Therapy of Intrabony DefectsRecruitingNCT05858411Not applicable1 country
- Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and PeriodontitisRecruitingNCT075362041 country
- Adjunctive Diode Laser Therapy in Non-Surgical Periodontal TherapyRecruitingNCT07446127Not applicable1 country
- Hyaluronic Acid and Octenidine Gel as an Adjunct to Non-surgical Periodontal TreatmentRecruitingNCT06522438Not applicable1 country
- Modified Widman Flap vs Fibre Retention Osseous Resective SurgeryRecruitingNCT06123000Not applicable1 country
- Comparison of Gingival Flap Procedure Using Conventional Surgical Loupes vs. Videoscope for VisualizationEnrolling by invitationNCT059320171 country
- Effectiveness of SRP+ Lipo-curcumin Gel for the Treatment of Stage III Periodontitis.RecruitingNCT06624241Not applicable1 country
- The Use of a Non-Incised Minimally Invasive Flap Procedure in Conjunction With Emdogain® MI Compared to Traditional SRCPRecruitingNCT05964699Not applicable1 country
- Relationship Between Contact Point to Attachment Level and Presence of Interdental PapillaRecruitingNCT061846071 country
- Non - Incised Papilla Versus Single Flap Technique In The Reconstruction Of Intrabony DefectRecruitingNCT06003322Not applicable1 country
- A Danish Nationwide Longitudinal Study on Prevalence of Periodontitis and Its Co-morbiditiesNot yet recruitingNCT05574231
- Efficacy of Camel Whey Protein and Camel Whey Protein Nanoparticles for Treating Intra-bony Periodontal DefectsCompletedNCT07358104Not applicable1 country
- Timing of Oral Hygiene Improvement Relative to Subgingival InstrumentationCompletedNCT07914400Not applicable1 country
- Salivary Free Amino Acid Profiles in Periodontitis: Associations With Clinical Parameters and Dynamic Responses to Non Surgical TherapyCompletedNCT07669233Not applicable1 country
- Method for Measuring Dental Mobility and Displacement ForceCompletedNCT06600867Not applicable1 country
- Therapeutic Application of Coconut Oil in Oral HealthCompletedNCT06049589Not applicable1 country
- Impact of Debridement Invasiveness on Attachment Gain After Antiinfective Periodontal TherapyCompletedNCT03098498Not applicable1 country
- Two Different Graft Harvesting Techniques Applied in Localized Gingival RecessionsCompletedNCT05923294Not applicable1 country
- Thyme Honey Mouthwash in Management of Periodontitis in Renal PatientsCompletedNCT06129097Not applicable1 country
- Diode Laser Photo Activation for Pocket Reduction Decontamination A Clinical StudyCompletedNCT06404190Phase 11 country
- Antimicrobial Photodynamic Therapy in Patients With Periodontal Disease and Type 2 Diabetes MellitusCompletedNCT05816941Not applicable
- ESWT on Human Gingival FibroblastsCompletedNCT05766293Not applicable1 country
- Manuka Honey as an Adjunct to Non-surgical Periodontal Therapy: Clinical StudyCompletedNCT05631600Phase 2/31 country
- Flap Thickness Upon Root Coverage With the Use of Acellular Dermal MatrixCompletedNCT04802473Not applicable1 country
- Effect of Adjunctive Use of Vitamin B3 and B9 on Myeloperoxidase Level in the GCF of Patients With Stage I and II PeriodontitisStatus unknownNCT05435378Early Phase 1
- Low-level Laser Therapy as an Adjunct to Non-surgical Periodontal TreatmentCompletedNCT05233501Not applicable1 country
- Periodontal Disease in Patients With Obstructive Sleep ApneaCompletedNCT045817981 country
- Added Benefit of L-PRF to Autogenous Bone Graft in the Treatment of Mandibular Degree II Furcation DefectsCompletedNCT03756493Not applicable1 country
- Accuracy of Pulp Sensibility Test on Teeth With Deep Periodontal PocketStatus unknownNCT04399135Not applicable1 country
- Effect of Trait Anxiety in Women on Oral Health Status and Oral Health Care-Seeking BehaviorStatus unknownNCT042748551 country
- Influence of Anatomical Factors Upon Root CoverageCompletedNCT04813302Not applicable1 country
- Non-Incised Papillae Surgical Approach (NIPSA) With and Without GraftCompletedNCT04712630Not applicable1 country
- Safety and Efficacy of Periodontal Surgery in Supra-alveolar-type Defects With or Without Straumann® EmdogainTerminatedNCT016149251 country
- Verify if Amelogenins Had Some Benefits in Improving Lower 2nd Molar Periodontal Healing After 3rd Molar ExtractionCompletedNCT04314726Phase 4
- Platelet-Rich Fibrin and Anorganic Bovine Bone vs Collagen Membrane and Anorganic Bovine Bone in Intrabony DefectsCompletedNCT03715374Not applicable1 country
- Bone Height and Extractions StudyStatus unknownNCT03909568Not applicable
- Autologous Fibrin Glue Application as an Adjunct to Nonsurgical Periodontal Treatment of Chronic PeriodontitisCompletedNCT04082949Early Phase 11 country
- Flavonoid Intake and Periodontal HealingCompletedNCT030731611 country
- Periodontal Changes Following Mid Maxillary DistractionCompletedNCT03686761Not applicable1 country
- Dietary Intakes and Periodontal Health: A Follow-Up StudyCompletedNCT030731741 country
- Platelet-rich Fibrin and Autogenous Bone vs Enamel Matrix Derivative and Autogenous Bone in Intrabony DefectsStatus unknownNCT03510780Not applicable1 country
- Effect of Photodynamic Therapy on Gingival Crevicular Cytokines in Periodontitis PatientsCompletedNCT03453476Not applicable
- T-PRF Provides Advantages on Periodontal Healing: A Split Mouth Clinical StudyCompletedNCT03027050Not applicable
- Photodynamic Therapy During Supportive Periodontal TherapyCompletedNCT02666573Phase 4
- Regeneration of Human Intrabony Defects With rhFGF-2/HACompletedNCT02337166Phase 1/2
- Diagnostic Biomarkers Related to Periodontal Disease Activity in DiabeticCompletedNCT02220751Phase 31 country
- Phase 3 Clinical Trial of Periodontal Tissue Regeneration Using Fibroblast Growth Factor-2(Trafermin)CompletedNCT00734708Phase 31 country
- Study on Regenerative Treatment of Intra-bony DefectsCompletedNCT00757159Phase 41 country