An interventional study of SRP and Fotosan 630 in Periodontitis, Adult, Periodontal Pocket and Periodontitis, sponsored by National University of Singapore. Completed. Open to participants aged 21 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-03-05.
Sponsored by National University of Singapore · Not applicable, Interventional, and Treatment
Help build ClinicalTrials.gg — short surveys, remote interviews or testing, in your language. Take part →
Systemically healthy periodontitis patients were recruited in this single-blind, split-mouth, randomized controlled clinical trial. After SRP, PDT was applied at probing depth (PD) ≥ 4 mm at test quadrant. At baseline, 3rd month and 6th month, clinical parameters and cytokine pattern in gingival crevicular fluids (GCFs) were analysed.
Periodontal parameters and cytokine IL-1β, IL-6, IL-8, TNF-α, MMP-8 levels were analysed.
377 studies on the registry are indexed under Chronic Periodontitis; 21 are open to participants now.
This study's enrollment of 51 is above the median of 46 across 307 interventional studies indexed under Chronic Periodontitis.
Browse Chronic Periodontitis studies →National University of Singapore is the lead sponsor of 212 studies on the registry; 54 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
HbA1c
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Scaling and root planing, photodynamic therapy using Fotosan 630
Device: SRP and Fotosan 630
Scaling and root planing only
After isolating the test quadrants with cotton roll, toluidine blue was applied into the deep pockets (PD ≥ 4mm) at the test quadrants for 10 seconds, followed by inserting a perio tip (15 or 21 mm depending on the depth of the pocket) that connected to a LED emitting device, and light was emitted for 20 seconds. Toluidine blue in the deep pocket was removed by injecting normal saline into the pocket.
Also known as: Fotosan 630, CMS Dental, Copenhagen, Denmark
Changes from baseline probing depth at 3rd month and 6th month
Clinical probing depth in mm
Time frame: 3 months and 6 months
Changes from baseline clinical attachment level at 3rd month and 6th month
Clinical attachment level in mm
Time frame: 3 months and 6 months
Changes from baseline gingival recession level at 3rd month and 6th month
Gingival recession level in mm
Time frame: 3 months and 6 months
Changes from baseline bleeding score at 3rd month and 6th month
Bleeding score in percentage
Time frame: 3 months and 6 months
Changes from baseline Interleukin-1 level at 3rd month and 6th month
Interleukin-1 level in gingival crevicular fluid
Time frame: 3 months and 6 months
Changes from baseline Interleukin-6 level at 3rd month and 6th month
Interlekin-6 level in gingival crevicular fluid
Time frame: 3 months and 6 months
Changes from baseline Interleukin-8 level at 3rd month and 6th month
Interleukin-8 level in gingival crevicular fluid
Time frame: 3 months and 6 months
Changes from baseline Tumour necrosis factor-alpha level at 3rd month and 6th month
Tumour necrosis factor-alpha level in gingival crevicular fluid
Time frame: 3 months and 6 months
Changes from baseline Matrix metalloproteinase-8 level at 3rd month and 6th month
Matrix metalloproteinase-8 level in gingival crevicular fluid
Time frame: 3 months and 6 months
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
Ran from Jan 2012 to primary completion in Mar 2013, 14 months.
Of 88 non-industry interventional studies with no phase under Chronic Periodontitis, half reached primary completion within 15 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 24. This study's 14 months is close to that.
Counting every sponsor, half of 89 studies reached it within 15 months; a quarter within 10 and three quarters within 24.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Feb 2018. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
National University of Singapore →