Otitis Media with Effusion clinical trials
The registry lists 88 studies for Otitis Media with Effusion across more than 10 countries. 17 are recruiting or about to start. 76 of them are mainly about Otitis Media with Effusion (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Who runs them
Otonomy, Inc. (4) · University Hospital Ostrava (3) · Vastra Gotaland Region (3) · Alcon Research (3) · Menzies School of Health Research (2) · Integra LifeSciences Corporation (2) · Assiut University (2) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (2)
What is being tested here
Drugs under test in Otitis Media with Effusion studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Triamcinolone Acetonide | 1 | 2 | 2 |
| Triamcinolone | 1 | 2 | 2 |
| Lansoprazole | 0 | 0 | 2 |
| OTO-201 | 0 | 2 | 2 |
| Amoxicillin | 0 | 1 | 2 |
| Mometasone Furoate | 0 | 0 | 1 |
| Levocetirizine | 0 | 0 | 1 |
| Therapeutic Steroid Hormone | 0 | 0 | 1 |
| Clavulanic Acid | 0 | 1 | 1 |
| Xylitol | 0 | 1 | 1 |
Drug classes tested here Corticosteroids 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7, phase 3 first
- Aug 2027Intranasal Corticosteroid Spray for Preventing Otitis Media With Effusion After Radiotherapy in Nasopharyngeal Carcinoma · Phase 3 · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Dec 2026Short-term Application of Lactoferrin Ventilation Tubes · Second Affiliated Hospital, Zhejiang University, School of Medicine
- Apr 2027Coherent Optical Detection of Middle Ear Disease · Medical College of Wisconsin
- Apr 2027SWIR Otoscopy Study · Stanford University
- Jun 2027Validating and AI Software for Assessment of Children With Ear Concerns · Glimpse Diagnostics, Inc.
- Jun 2027CLIKX® Tympanostomy Tube Delivery System for the Placement of Tympanostomy Tubes · ClinQure, Inc.
- Nov 2027EarFlo: A Non-Invasive Treatment for Otitis Media With Effusion & Eustachian Tube Dysfunction in Adults · Philip Perez
Who these studies take
Of the 8 Otitis Media with Effusion studies recruiting now, 1 (13%) set no upper age limit and 7 (88%) stop at 75 or younger. 8 (100%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (25%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (63%) | 5 (63%) |
| 18 | 2 (25%) | 2 (25%) |
| 30 | 1 (13%) | 1 (13%) |
| 40 | 1 (13%) | 1 (13%) |
| 50 | 1 (13%) | 1 (13%) |
| 65 | 1 (13%) | 1 (13%) |
| 75 | 1 (13%) | 1 (13%) |
| 85 | 1 (13%) | 1 (13%) |
Across all 88 studies, recruiting or not: 84% stop at 75 or younger and 78% at 65; 90% take children; 2% are for women only and 0% for men only; 20% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Otitis Media with Effusion studies take
Of 16 interventional studies with no phase under Otitis Media with Effusion, half reached primary completion within 48 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 48 mo10–65 · 16 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered3
- Short-term Application of Lactoferrin Ventilation TubesNov 3, 2026NCT07913490
- Balloon Dilation of Eustachian Tube Versus Tympanostomy Tube in Management of Pediatric Obstructive Eustachian Tube DysfunctionOct 27, 2026NCT07899177
- Towards Implementation of Universal Newborn Hearing Screening in KenyaOct 16, 2026NCT07879326
Studies
Recruiting first, then most recently updated. Showing 50 of 88. Browse all 88 → or search them.
- EarFlo: A Non-Invasive Treatment for Otitis Media With Effusion & Eustachian Tube Dysfunction in AdultsNot yet recruitingNCT07777302Not applicable1 country
- Short-term Application of Lactoferrin Ventilation TubesNot yet recruitingNCT07913490Not applicable
- CLIKX® Tympanostomy Tube Delivery System for the Placement of Tympanostomy TubesRecruitingNCT07625657Not applicable1 country
- Towards Implementation of Universal Newborn Hearing Screening in KenyaRecruitingNCT07879326Not applicable1 country
- SWIR Otoscopy StudyRecruitingNCT06944795Not applicable1 country
- Osteopathic Manipulative Treatment for Children With Chronic or Recurrent Otitis MediaNot yet recruitingNCT07639775Not applicable1 country
- Evaluating Laser Otoscope for Middle Ear Effusion DetectionNot yet recruitingNCT074545121 country
- Coherent Optical Detection of Middle Ear DiseaseRecruitingNCT05353569Not applicable1 country
- Gamified Training and AI Support for Improving Ear Infection Diagnosis in Primary CareNot yet recruitingNCT07246551Not applicable
- Validating and AI Software for Assessment of Children With Ear ConcernsNot yet recruitingNCT07243093
- Intranasal Corticosteroid Spray for Preventing Otitis Media With Effusion After Radiotherapy in Nasopharyngeal CarcinomaNot yet recruitingNCT07189572Phase 3
- It is Accepted That Adenoid Hypertrophy is Related to Otitis Media With Effusion Incidence. Better Understanding of the Correlation Between the Relative Size of AH and the Incidence of Persistent OME May Provide Evidence to Support a More Standardized Approach to the Diagnosis and Treatment of OME.Not yet recruitingNCT06674720
- Evaluation of Outcomes Following In-office Tympanostomy Using the Tula® System: a Prospective, Multi-center RegistryRecruitingNCT059150781 country
- Microplastics in Otitis Media With Effusion MaterialRecruitingNCT063166351 country
- Effect of Ventilation Tubes in Otitis-prone ChildrenRecruitingNCT05348291Not applicable1 country
- Adjuvant Adenoidectomy for the Treatment of Chronic OME in ChildrenNot yet recruitingNCT05545345Not applicable
- Sound Ear Check (SEC) in Hearing Diagnostics in Young ChildrenRecruitingNCT055356341 country
- Balloon Dilation of Eustachian Tube Versus Tympanostomy Tube in Management of Pediatric Obstructive Eustachian Tube DysfunctionCompletedNCT07899177Not applicable1 country
- Omega-3-Based Nutraceutical Supplementation as Adjunctive Therapy in Adults With Otitis Media With Effusion: A Multicenter, Double-Blind, Randomized Placebo-Controlled TrialCompletedNCT07721610Phase 41 country
- Laser Acupuncture for Otitis Media With Effusion in ChildrenCompletedNCT07242001Not applicable1 country
- Otitis Treatment With OtoSight™ - Modification of Antibiotic Treatment Intervention in ChildrenActive, not recruitingNCT062858121 country
- Evaluation of Blowing Exercises Utilizing a Breathing Exercise Device in Otitis Media With EffusionCompletedNCT06967506Not applicable1 country
- Short-term Effects of Ventilation Tubes in Children With Chronic Otitis Media With EffusionCompletedNCT06100159Not applicable1 country
- Autoinflation as a Eustachian Tube RehabilitationCompletedNCT07122999Not applicable1 country
- Hearing Improvement After Making a Hole Surgically in Eardrum With or Without Ventilation Tube in Children With Glue EarsCompletedNCT06909084Not applicable1 country
- Evaluation of the Tympanostomy Tube Delivery SystemCompletedNCT01202578Phase 2/31 country
- Clinical Study of the Tympanostomy Tube Delivery SystemCompletedNCT00939796Not applicable1 country
- Distribution of Bacteria in OME After Radiotherapy For NPC.Status unknownNCT065239331 country
- Otitis Media With Effusion and Type 2 Inflammation DiseasesCompletedNCT06403319
- Testing a New App for Children With Glue EarCompletedNCT06256081Not applicable1 country
- Clinical Development of Deep Learning for the OtoSightCompletedNCT047227701 country
- Wideband Tympanometry in Otitis Media With EffusionCompletedNCT04395261
- Balloon Eustachian Tuboplasty in Treatment of Chronic Eustachian Tube DysfunctionCompletedNCT03556215Not applicable1 country
- Autoinflation: Alternative in the Treatment of Otitis Media With EffusionStatus unknownNCT05324696Not applicable1 country
- Treatment and Prevention of Middle Ear Morbidity in Head and Neck Cancer Patients Following RadiotherapyCompletedNCT02716376Not applicable
- A Prospective, Randomized, Controlled Clinical Study of BET Combined With Tympanostomy Tube Insertion in the Treatment of Intractable OME After Radiotherapy for NPCStatus unknownNCT05449184Not applicable1 country
- The Effects of Exosomes in Otitis Media With EffusionStatus unknownNCT05402267
- In-Office Tympanostomy Tube Placement in Children (OTTER)CompletedNCT03323736Phase 32 countries
- The Effect of Osteopatic Cranial Techniques on the Audiometric and Tympanometric Values in Children Suffering From Otitis Media With Effusion.WithdrawnNCT00547326Not applicable1 country
- Prevalence of Mucosal Biofilm Formations in Adenoidectomy SpecimensCompletedNCT01022944Not applicable1 country
- Effect of Probiotics on Nasopharyngeal Microbiome of Children With Otitis Media With EffusionCompletedNCT03277820Not applicable1 country
- Wide Frequency Band Test of Hearing in VeteransCompletedNCT020198881 country
- Open-Label Study of OTO-201 for Middle Ear Effusion Evaluating Trans-Tympanostomy Tube AdministrationCompletedNCT02350998Phase 31 country
- Secretory Otitis Media in Adenoids Hypertrophy PatientsStatus unknownNCT04584073Not applicable
- Efficacy and Cost Analysis of Steroids in Treatment of Otitis Media With EffusionCompletedNCT03590912Phase 41 country
- Exploring Interventions for Glue Ear During Covid-19Status unknownNCT04427631Not applicable1 country
- The URT and Middle Ear Microbiota in Health and During Chronic OMECompletedNCT031094961 country
- Adult Study to Evaluate Placement of Tympanostomy Tubes In-office (ADEPT)CompletedNCT03197558Phase 21 country
- Tympanostomy Tube Extrusion Time & ViscosityCompletedNCT038480261 country
- A Non-invasive Device to Remove Fluid From the Middle EarStatus unknownNCT03978195Not applicable