Neoplastic Syndromes, Hereditary clinical trials
The registry lists 47 studies for Neoplastic Syndromes, Hereditary across more than 10 countries. 26 are recruiting or about to start. 23 of them are mainly about Neoplastic Syndromes, Hereditary (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13. Counting its 15 narrower conditions too, such as Wilms Tumor: 1,021 studies, 260 open.
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Breast cancer · Recruiting: 2 came in, 3 changed
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A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
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Status
Who runs them
National Cancer Institute (NCI) (6) · University Health Network, Toronto (3) · Weill Medical College of Cornell University (3) · University of Michigan Rogel Cancer Center (2) · Columbia University (2) · National Cancer Centre, Singapore (2) · OHSU Knight Cancer Institute (1) · Vanderbilt-Ingram Cancer Center (1)
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 8
- Dec 2026Implementation of Population Cancer Genetic Services in Federally Qualified Health Centers (FQHC) · University of Illinois at Chicago
- Dec 2026Urothelial Cancer Screening in Individuals With Lynch Syndrome Using a Urine Tumor DNA Panel (LS-URO Study) · Tampere University Hospital
- Dec 2026Discovering New Targets for Colorectal and Endometrial Cancer Risk Reduction · Weill Medical College of Cornell University
- Mar 2027Closing the GAPS: Guideline Adherence, Prevention and Surveillance in Hereditary Cancer · Nest Genomics
- Jun 2027Trial of Combined Obstetric Carrier Screening and Hereditary Cancer Screening · Weill Medical College of Cornell University
- Jul 2027Applying Population Management Best Practices to Preventative Genomic Medicine Trial · University of Washington
- Jul 2027Feasibility Study of a Chatbot AI-Driven Preliminary Screening System for Hereditary Cancer Syndromes · National Cancer Centre, Singapore
- Sep 2027PreCharge: An Innovative Digital Program to Increase Coping, Resilience, and Health Care Engagement Among Cancer Previvors · Pro-Change Behavior Systems
Who these studies take
Of the 20 Neoplastic Syndromes, Hereditary studies recruiting now, 11 (55%) set no upper age limit and 6 (30%) stop at 75 or younger. 7 (35%) take children under 18. 3 (15%) are for women only and 0 (0%) for men only; 9 (45%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 7 (35%) | 7 (35%) |
| 18 | 16 (80%) | 14 (70%) |
| 30 | 17 (85%) | 14 (70%) |
| 40 | 17 (85%) | 14 (70%) |
| 50 | 18 (90%) | 15 (75%) |
| 65 | 16 (80%) | 15 (75%) |
| 75 | 16 (80%) | 15 (75%) |
| 85 | 14 (70%) | 14 (70%) |
Across all 46 studies, recruiting or not: 22% stop at 75 or younger and 13% at 65; 33% take children; 9% are for women only and 0% for men only; 43% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 14, 2026.
Newly registered3
- PreCharge: An Innovative Digital Program to Increase Coping, Resilience, and Health Care Engagement Among Cancer PrevivorsNov 13, 2026NCT07936682
- Feasibility Study of a Chatbot AI-Driven Preliminary Screening System for Hereditary Cancer SyndromesOct 28, 2026NCT07901543
- EHR Intervention to Increase HBOC Genetic TestingOct 15, 2026NCT07876349
Studies
Recruiting first, then most recently updated. Showing 47 of 47. search them.
- PreCharge: An Innovative Digital Program to Increase Coping, Resilience, and Health Care Engagement Among Cancer PrevivorsNot yet recruitingNCT07936682Not applicable
- Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant DiseaseRecruitingNCT000268841 country
- Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated ConditionsRecruitingNCT031602741 country
- Feasibility Study of a Chatbot AI-Driven Preliminary Screening System for Hereditary Cancer SyndromesRecruitingNCT079015431 country
- Study of Skin Tumors in Tuberous SclerosisRecruitingNCT000019751 country
- Feasibility Trial of Combination of Obstetrical Carrier Screening and Hereditary Cancer ScreeningRecruitingNCT071950711 country
- EHR Intervention to Increase HBOC Genetic TestingRecruitingNCT07876349Not applicable1 country
- CfDNA in Hereditary And High-risk Malignancies 2RecruitingNCT067266421 country
- Discovering New Targets for Colorectal and Endometrial Cancer Risk ReductionRecruitingNCT060966881 country
- Identifying and Caring for Individuals With Inherited Cancer SyndromeRecruitingNCT04494945Not applicable1 country
- Patient Centered Clinical Decision Support for Hereditary Cancer SyndromesEnrolling by invitationNCT06914726Not applicable1 country
- Psychological Support and Psycho-Emotional Trajectories in Cancer Genetics.Not yet recruitingNCT07695506
- Chatbot to Maximize Hereditary Cancer Genetic Risk AssessmentRecruitingNCT05562778Not applicable1 country
- Navigation Interventions to Improve Cascade Genetic Testing Among Relatives of Patients With Hereditary Cancer SyndromesRecruitingNCT06927947Not applicable1 country
- A Web-Based Program (Kindred) to Improve the Understanding of Genetic Cancer Risk and Cancer Genetic Testing in African American FamiliesNot yet recruitingNCT07542405Not applicable1 country
- Questionnaire on Congenital Cancer Signs Through Self-AssessmentRecruitingNCT07378423Not applicable1 country
- Lynch Syndrome X-Talk of Enteral Mucosa With Immune SystemRecruitingNCT067084292 countries
- Li-Fraumeni & TP53 (LiFT UP): Understanding and ProgressRecruitingNCT045416541 country
- Applying Population Management Best Practices to Preventative Genomic Medicine TrialEnrolling by invitationNCT07053813Not applicable1 country
- Pre-myeloid Cancer and Bone Marrow Failure Clinic StudyRecruitingNCT02958462Not applicable1 country
- Strategy for Management of Patients With Hereditary Cancer Syndromes (HCS) in a Rural EnvironmentEnrolling by invitationNCT07381985Not applicable1 country
- Implementation of Population Cancer Genetic Services in Federally Qualified Health Centers (FQHC)RecruitingNCT05664867Not applicable1 country
- Trial of Combined Obstetric Carrier Screening and Hereditary Cancer ScreeningRecruitingNCT07052266Not applicable1 country
- Urothelial Cancer Screening in Individuals With Lynch Syndrome Using a Urine Tumor DNA Panel (LS-URO Study)RecruitingNCT06218433Not applicable2 countries
- Shwachman-Diamond Syndrome Global Patient Survey and Partnering PlatformRecruitingNCT069999541 country
- Cancer Predisposition Testing by Family-based Whole-genome Sequencing (WGS) in Every Child With Newly Diagnosed CancerRecruitingNCT049037821 country
- Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric CancerCompletedNCT030304041 country
- Genetic Testing Decision AidCompletedNCT05470920Not applicable1 country
- Closing the GAPS: Guideline Adherence, Prevention and Surveillance in Hereditary CancerActive, not recruitingNCT06654466Not applicable1 country
- Family History and Cancer Risk StudyCompletedNCT050793341 country
- Sequential EHR Based Interventions to Increase Genetic Testing for Breast and Ovarian Cancer PredispositionCompletedNCT05721326Not applicable1 country
- Increasing Uptake of Cascade Testing in Families With Familial Cancer Syndromes: A Randomized Controlled Trial of a Registry-aided Model.CompletedNCT07626814Not applicable1 country
- Familial Adenomatous Poliposys Italian Network (Rete Italiana Poliposi Adenomatosa Familiare)Active, not recruitingNCT074612461 country
- Cell-free DNA in Hereditary And High-Risk Malignancies 1Active, not recruitingNCT042619721 country
- Integrative Sequencing In Germline and Hereditary TumoursActive, not recruitingNCT038575941 country
- Improving Care After Inherited Cancer TestingActive, not recruitingNCT04763915Not applicable1 country
- Cancer Health Assessments Reaching ManyCompletedNCT03426878Not applicable1 country
- Epidemiology of Pituitary Tumours: Prevalence of Associated NeoplasiaStatus unknownNCT039734501 country
- Inherited Risk Evaluation Tool (InheRET): Identifying Patients at Increased Risk for Hereditary DiseaseStatus unknownNCT04510896Not applicable1 country
- Biomarker Monitoring in TP53 Mutation CarriersCompletedNCT022893261 country
- Evaluation of the Adhesion to the GENEPY NetworkStatus unknownNCT039796121 country
- Everolimus Therapy in People With Birt-Hogg-Dube Syndrome (BHD)-Associated Kidney Cancer or Sporadic Chromophobe Renal CancerTerminatedNCT02504892Phase 21 country
- Microarray Analysis for Human Genetic DiseaseCompletedNCT000018984 countries
- Prevention of Progression of Duodenal Adenomas in Patients With Familial Adenomatous PolyposisCompletedNCT00808743Phase 2/31 country
- Establishment of Normal Breast Epithelial Cell Lines From Patients at High Risk for Breast CancerCompletedNCT000014961 country
- Genetic Analysis of Inherited Urologic Malignant Disorders: Collection of SamplesCompletedNCT000018141 country
- Familial Prostate CancerCompletedNCT000013771 country