Adenomatous Polyposis Coli clinical trials
The registry lists 92 studies for Adenomatous Polyposis Coli across more than 10 countries. 29 are recruiting or about to start. 69 of them are mainly about Adenomatous Polyposis Coli (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-22.
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Who runs them
National Cancer Institute (NCI) (8) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (4) · M.D. Anderson Cancer Center (3) · Janssen Research & Development, LLC (3) · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano (3) · Charite University, Berlin, Germany (3) · Yonsei University (3) · Rapamycin Holdings Inc. (2)
What is being tested here
Drugs under test in Adenomatous Polyposis Coli studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Celecoxib | 1 | 2 | 4 |
| Encapsulated Rapamycin | 1 | 1 | 2 |
| Sirolimus | 1 | 0 | 2 |
| Metformin | 1 | 1 | 2 |
| Thiamine | 1 | 0 | 1 |
| Dordaviprone | 1 | 0 | 1 |
| EP2/EP4 Antagonist TPST-1495 | 1 | 0 | 1 |
| TAK 733 | 1 | 0 | 1 |
| Tegavivint | 1 | 0 | 1 |
| Sulindac | 0 | 2 | 4 |
Drug classes tested here NSAIDs 1 open · Tyrosine kinase inhibitors (TKIs) 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9
- Nov 2026A Personalized Surveillance and Intervention Protocol for Patients With Familial Adenomatous Polyposis That Have Undergone (Procto)Colectomy · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Nov 2026A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Familial Adenomatous Polyposis · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Dec 2026Artificial Intelligence-assisted Colonoscopy in the Detection and Characterization of Colorectal Lesions · Instituto do Cancer do Estado de São Paulo
- Mar 2027Impact of Prior Identification and Education of Patients Requiring a Digestive Stoma for Fecal Diversion · Assistance Publique Hopitaux De Marseille
- Apr 2027FOG-001 in Locally Advanced or Metastatic Solid Tumors · Parabilis Medicines, Inc.
- Jun 2027Evaluate REC-4881 in Participants With Familial Adenomatous Polyposis (FAP) · Recursion Pharmaceuticals Inc.
- Jun 2027An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis · National Cancer Institute (NCI)
- Oct 2027Investigation of β-hydroxybutyrate Supplementation as Chemoprevention in Familial Adenomatous Polyposis · Abramson Cancer Center at Penn Medicine
- Oct 2027Cold Snare Polypectomy for Duodenal Adenomas in Familial Adenomatous Polyposis · Western Sydney Local Health District
Who these studies take
Of the 21 Adenomatous Polyposis Coli studies recruiting now, 16 (76%) set no upper age limit and 2 (10%) stop at 75 or younger. 1 (5%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (14%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (5%) | 1 (5%) |
| 18 | 19 (90%) | 19 (90%) |
| 30 | 21 (100%) | 21 (100%) |
| 40 | 21 (100%) | 21 (100%) |
| 50 | 21 (100%) | 21 (100%) |
| 65 | 19 (90%) | 19 (90%) |
| 75 | 19 (90%) | 19 (90%) |
| 85 | 18 (86%) | 18 (86%) |
Across all 92 studies, recruiting or not: 26% stop at 75 or younger and 17% at 65; 23% take children; 0% are for women only and 0% for men only; 7% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 14, 2026.
Results posted1
Studies
Recruiting first, then most recently updated. Showing 50 of 92. Browse all 92 → or search them.
- Testing for Safety and Colorectal Cancer Preventive Effects of ONC201RecruitingNCT05630794Phase 11 country
- FOG-001 in Locally Advanced or Metastatic Solid TumorsRecruitingNCT05919264Phase 1/22 countries
- Investigation of β-hydroxybutyrate Supplementation as Chemoprevention in Familial Adenomatous PolyposisEnrolling by invitationNCT06578637Not applicable1 country
- An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous PolyposisRecruitingNCT06557733Phase 21 country
- A Safety Study of ST316 in Participants With Familial Adenomatous Polyposis (FAP).Not yet recruitingNCT07729371Phase 1
- Evaluation of the Ileo-anal Pouch in FAP (ENDOPOL)RecruitingNCT07726771Not applicable1 country
- Expanded Access to 0.5 mg eRapa for Familial Adenomatous PolyposisAvailableNCT07689942
- Integrated Cancer Repository for Cancer ResearchRecruitingNCT020126991 country
- Artificial Intelligence-assisted Colonoscopy in the Detection and Characterization of Colorectal LesionsRecruitingNCT07066046Not applicable1 country
- Familial Investigations of Childhood Cancer PredispositionRecruitingNCT030502681 country
- Evaluate REC-4881 in Participants With Familial Adenomatous Polyposis (FAP)RecruitingNCT05552755Phase 1/21 country
- Phase 3 Trial of eRapa in Patients With Familial Adenomatous PolyposisRecruitingNCT06950385Phase 37 countries
- Microbial and Environmental Factors Associated With Polyps Development in Familial Adenomatous Polyposis (MicrobEnvironment in FAP)RecruitingNCT066147381 country
- Trial of Exercise Therapy in Familial Adenomatous Polyp (FAP)RecruitingNCT06641310Not applicable1 country
- Safety Study for the Use of Rapamycin in Children With Familial Adenomatous PolyposisNot yet recruitingNCT06308445Phase 21 country
- Efficacy of Vitamin B1 in Familial Adenomatous Polyposis Patients.Enrolling by invitationNCT06649825Not applicable1 country
- Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal CarcinomaRecruitingNCT07463599Phase 1/21 country
- A Personalized Surveillance and Intervention Protocol for Patients With Familial Adenomatous Polyposis That Have Undergone (Procto)ColectomyRecruitingNCT046780112 countries
- A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Familial Adenomatous PolyposisRecruitingNCT046779982 countries
- Impact of Prior Identification and Education of Patients Requiring a Digestive Stoma for Fecal DiversionNot yet recruitingNCT06881303Not applicable1 country
- Duodenal Polyposis Classification in FAPRecruitingNCT071991271 country
- Ten Versus Fifteen Centimeter Pouch in IPAA SurgeryRecruitingNCT06538402Not applicable1 country
- Cold Snare Polypectomy for Duodenal Adenomas in Familial Adenomatous PolyposisRecruitingNCT034714031 country
- Chemopreventive Effect of Combination of Celecoxib and Metformin in Patients With Familial Adenomatous PolyposisRecruitingNCT06545526Phase 31 country
- Cold Atmospheric Plasma for the Endoscopic Treatment of Duodenal Polyps in Patients With Familial Adenomatous PolyposisRecruitingNCT06435533Not applicable1 country
- Inherited Cancer Early Diagnosis (ICED) StudyRecruitingNCT061633651 country
- DNA Adductomics for Colorectal Cancer InvestigationRecruitingNCT048656011 country
- Detection of Ileoanal Pouch/Reservoir AdenomasNot yet recruitingNCT05954949
- Colorectal Adenoma Canceration in FAPNot yet recruitingNCT045319301 country
- Trial of eRapa to Prevent Progression in Familial Adenomatous Polyposis Patients Under Active SurveillanceCompletedNCT04230499Phase 21 country
- CryoBalloon Ablation for Treatment of Duodenal AdenomasCompletedNCT03847636Not applicable1 country
- Review of Post-Study Clinical Endoscopy Reports in Follow Up to MAY2016-07-01TerminatedNCT046742281 country
- Testing Obeticholic Acid for Familial Adenomatous PolyposisTerminatedNCT05223036Phase 22 countries
- Familial Adenomatous Poliposys Italian Network (Rete Italiana Poliposi Adenomatosa Familiare)Active, not recruitingNCT074612461 country
- Visualization of the Papilla Through Use of the NuView Device in Patients With FAPCompletedNCT056571451 country
- LATA-IBD TRIAL a Controlled Feasibility Study for the Introduction of Transanal Minimally Invasive IPAA-Surgery. Evaluation of Operative Results and Bowel Function After Introducing Transanal IPAA-surgery to Replace Conventional Laparoscopic IPAA-surgery.CompletedNCT072786871 country
- Endoscopic Papillectomy for Ampullary AdenomasCompletedNCT03494543
- A Study of Guselkumab in Participants With Familial Adenomatous PolyposisCompletedNCT03649971Phase 19 countries
- Post-Trial Access for Guselkumab in Participants With Familial Adenomatous PolyposisNo longer availableNCT04948398
- Sirolimus and Familial Adenomatous Polyposis (FAP)CompletedNCT03095703Phase 21 country
- The CHAMP-study: The CHemopreventive Effect of Lithium in Familial AdenoMatous PolyposisCompletedNCT05402891Phase 21 country
- Observational Familial Adenomatous Polyposis Registry Study In Patients Receiving Celecoxib Compared to Control PatientsTerminatedNCT001514764 countries
- Effect of EPA-FFA on Polypectomy in Familial Adenomatous PolyposisActive, not recruitingNCT03806426Phase 31 country
- Molecular Fluorescence Endoscopy in Patients With Familial Adenomatous Polyposis, Using Bevacizumab-IRDye800CWCompletedNCT02113202Phase 11 country
- A Clinical Trial of the Effectiveness and Safety of Software Assisting Diagnose the Intestinal Polyp Digestive Endoscopy by Analysis of Colonoscopy Medical Images From Electronic Digestive Endoscopy EquipmentCompletedNCT05687318Not applicable1 country
- A Study of JNJ-64251330 in Participants With Familial Adenomatous PolyposisCompletedNCT05014360Phase 17 countries
- Molecular Targeting of 15-Lipoxygenase-1 (15-LOX-1) for Apoptosis Induction in Human Colorectal CancersCompletedNCT00503035Phase 21 country
- Erlotinib Hydrochloride in Reducing Duodenal Polyp Burden in Patients With Familial Adenomatous Polyposis at Risk of Developing Colon CancerCompletedNCT02961374Phase 22 countries
- Incidental Cancer in Familial Adenomatous PolyposisCompletedNCT051714261 country
- Registry With Information About Colitis Ulcerosa and Familial Adenomatous Polyposis PatientsCompletedNCT016045641 country