An observational study in Stomach Neoplasms, Stomach Cancer and Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS), sponsored by National Cancer Institute (NCI). Completed at 1 site in United States. Open to participants aged 2 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-16.
Sponsored by National Cancer Institute (NCI) · Observational
Background:
Gastric cancers are cancers of the stomach. Hereditary ones are passed from parent to child. Researchers want to gather data about hereditary gastric cancers. They want to learn about changes these cause in the body and about the genes involved.
Objective:
-To gather data about hereditary gastric cancer.
Eligibility:
Design:
Participants will have:
Background:
An estimated 1-3% of gastric cancer cases occur within a familial background as part of an inherited cancer syndrome.
Hereditary Diffuse Gastric Cancer (HDGC) is the most frequent form of familial gastric cancer and has been linked to a germline mutation in the CDH1 gene.
Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS) is a more recently described autosomal dominant syndrome characterized by fundic gland polyposis with antral sparing.
Other germline mutations that predispose to gastric cancer such as SDH (succinate dehydrogenase protein subunits) gene and CTNNA1 (alpha catenin).
Objectives:
Characterize the natural and clinical histories of hereditary gastric cancer syndromes.
Eligibility:
Individuals, and family members, who fulfill clinical criteria for a hereditary gastric cancer syndrome irrespective of previous genetic testing or treatment.
Design:
These rare families will be recruited to genetically confirm diagnosis and study the natural history of hereditary gastric cancers.
Genetic testing will be offered to gain appreciation of the effect of mutations on the relative activity of various germline and somatic mutations.
We will determine if there is a relationship between mutation and disease phenotype.
Individuals, and family members, who fulfill clinical criteria for a hereditary gastric cancer syndrome irrespective of previous genetic testing or treatment
An individual, or their family members, with any of the following:
EXCLUSION CRITERIA:
None.
Subjects with suspicious personal or family medical history of gastric cancer or gastric cancer syndrome.
Characterization of the natural and clinical histories of hereditary gastric cancer syndromes
Characterization of the natural and clinical histories of hereditary gastric cancer syndromes
Time frame: 10 years
Plan to share: Yes — All IPD recorded in the medical record will be shared with intramural investigators upon request. @@@@@@In addition, all large scale genomic sequencing data will be shared with subscribers to dbGaP.
Supporting information: Study protocol, Sap, Icf
This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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National Cancer Institute (NCI)