Colorectal Neoplasms, Hereditary Nonpolyposis clinical trials

The registry lists 146 studies for Colorectal Neoplasms, Hereditary Nonpolyposis across more than 10 countries. 60 are recruiting or about to start. 86 of them are mainly about Colorectal Neoplasms, Hereditary Nonpolyposis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13.

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Status

Completed: 45
Recruiting: 43
Active, not recruiting: 17
Not yet recruiting: 15
Status unknown: 14
Terminated: 6

Phase

Phase 2: 10
Phase 1: 6
Phase 3: 6
Early Phase 1: 4

Where

United States: 71
France: 12
United Kingdom: 12
Netherlands: 11
Italy: 10
Canada: 8

Who runs them

M.D. Anderson Cancer Center (11) · National Cancer Institute (NCI) (7) · Assistance Publique - Hôpitaux de Paris (5) · University Health Network, Toronto (4) · Geisinger Clinic (3) · San Raffaele University (3) · Lei Li (3) · Kaiser Permanente (3)

What is being tested here

Drugs under test in Colorectal Neoplasms, Hereditary Nonpolyposis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Naproxen	1	0	2
Mesalamine	1	0	2
Dendritic Cell	1	0	1
Nivolumab	0	0	2
Atezolizumab	0	1	1
Pembrolizumab	0	0	1
Acetylsalicylic acid lysinate	0	1	1
Omacor	0	0	1
Atorvastatin	0	0	1
Tislelizumab	0	0	1

Drug classes tested here Immune checkpoint inhibitors 1 open · NSAIDs 1 open

Coming up

5phase 3 studies under way

15studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest

Nov 2026Determining the Prevalence of Muir-Torre Syndrome in Patients With Lynch Syndrome · Centre Hospitalier Universitaire de Nīmes
Dec 2026Multi-Organ Screening Recommendations in Patients With Lynch Syndrome · Memorial Sloan Kettering Cancer Center
Dec 2026Urothelial Cancer Screening in Individuals With Lynch Syndrome Using a Urine Tumor DNA Panel (LS-URO Study) · Tampere University Hospital
Feb 2027Metagenomic Evaluation of the Gut Microbiome in Patients With Lynch Syndrome and Other Hereditary Colonic Polyposis Syndromes · Memorial Sloan Kettering Cancer Center
Mar 2027Menstrual Cup for Early Endometrial Cancer Detection in Lynch Syndrome · Jessica D. St. Laurent, MD
Mar 2027Predictive Value of PREMM5, MMRpredict, and Universal Tumor Screening for Lynch Syndrome in Vietnam · University of Medicine and Pharmacy at Ho Chi Minh City
Apr 2027Assessing Uterine Cancer Risk in Lynch Syndrome Carriers Using Vaginal Self-sampling and a Health Questionnaire · University of British Columbia
Jul 2027The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics · H. Lee Moffitt Cancer Center and Research Institute
Jul 2027Testing a Combination of Vaccines for Cancer Prevention in Lynch Syndrome · National Cancer Institute (NCI)
Jul 2027Liquid Biopsy Evaluation and Repository Development at Princess Margaret · University Health Network, Toronto

Who these studies take

Of the 43 Colorectal Neoplasms, Hereditary Nonpolyposis studies recruiting now, 32 (74%) set no upper age limit and 4 (9%) stop at 75 or younger. 4 (9%) take children under 18. 3 (7%) are for women only and 3 (7%) for men only; 16 (37%) take healthy volunteers.

Recruiting studies that take each age, of 43
Age	Women	Men
10	3 (7%)	3 (7%)
18	35 (81%)	34 (79%)
30	39 (91%)	38 (88%)
40	39 (91%)	39 (91%)
50	40 (93%)	40 (93%)
65	40 (93%)	40 (93%)
75	39 (91%)	39 (91%)
85	34 (79%)	33 (77%)

Across all 146 studies, recruiting or not: 18% stop at 75 or younger and 5% at 65; 16% take children; 13% are for women only and 3% for men only; 29% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Colorectal Neoplasms, Hereditary Nonpolyposis studies take

Of 37 interventional studies with no phase under Colorectal Neoplasms, Hereditary Nonpolyposis, half reached primary completion within 46 months of starting, counting those still running.

Start to primary completion	Every sponsor	Industry	Non-industry
Interventional, no phase	46 mo27–86 · 37 studies	—	—

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 15, 2026.

Newly registered2

PreCharge: An Innovative Digital Program to Increase Coping, Resilience, and Health Care Engagement Among Cancer PrevivorsNov 13, 2026NCT07936682
Protocol for Non-invasive Gynaecological Surveillance in Lynch SyndromeOct 16, 2026NCT07877779

Studies

Recruiting first, then most recently updated. Showing 50 of 146. Browse all 146 → or search them.