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Neurofibromatosis 2 clinical trials

The registry lists 47 studies for Neurofibromatosis 2 across 7 countries. 10 are recruiting or about to start. 37 of them are mainly about Neurofibromatosis 2 (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.

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Status

Completed
25
Terminated
7
Recruiting
5
Not yet recruiting
4
Active, not recruiting
3
Enrolling by invitation
1

Phase

Phase 2
24
Phase 1
5
Early Phase 1
3
Phase 3
2

Where

United States
34
China
5
United Kingdom
3
France
2
Netherlands
1
Puerto Rico
1

Who runs them

Massachusetts General Hospital (5) · NYU Langone Health (5) · Massachusetts Eye and Ear Infirmary (5) · Beijing Tiantan Hospital (4) · FDA Office of Orphan Products Development (2) · University of Alabama at Birmingham (2) · Manchester University NHS Foundation Trust (1) · St. Jude Children's Research Hospital (1)

What is being tested here

Drugs under test in Neurofibromatosis 2 studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
AZD 6244203
Luvometinib202
Brigatinib101
Neratinib101
Retifanlimab101
Bevacizumab004
Everolimus004
Lapatinib002
REC-2282012
Doxycycline001

Drug classes tested here Tyrosine kinase inhibitors (TKIs) 1 open · Angiogenesis inhibitors 6 · mTOR inhibitors 5

Coming up

0phase 3 studies under way
2studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 2

Who these studies take

Of the 5 Neurofibromatosis 2 studies recruiting now, 4 (80%) set no upper age limit and 1 (20%) stop at 75 or younger. 4 (80%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.

Recruiting studies that take each age, of 5
AgeWomenMen
103 (60%)3 (60%)
184 (80%)4 (80%)
304 (80%)4 (80%)
404 (80%)4 (80%)
504 (80%)4 (80%)
654 (80%)4 (80%)
754 (80%)4 (80%)
854 (80%)4 (80%)

Across all 47 studies, recruiting or not: 13% stop at 75 or younger and 13% at 65; 57% take children; 0% are for women only and 0% for men only; 6% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

What changed recently

From the registry's own updates since Oct 14, 2026.

Results posted1

Studies

Recruiting first, then most recently updated. Showing 47 of 47. search them.