Hereditary Breast and Ovarian Cancer Syndrome clinical trials
The registry lists 62 studies for Hereditary Breast and Ovarian Cancer Syndrome across more than 10 countries. 13 are recruiting or about to start. 40 of them are mainly about Hereditary Breast and Ovarian Cancer Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13.
Get an email when these change. Save the Hereditary Breast and Ovarian Cancer Syndrome studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your alerts, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your alerts. Stop any time.
Who runs them
Georgetown University (6) · M.D. Anderson Cancer Center (3) · National Cancer Institute (NCI) (3) · Gynecologic Oncology Group (2) · Abramson Cancer Center at Penn Medicine (2) · Technical University of Munich (2) · Sheba Medical Center (2) · University Health Network, Toronto (2)
What is being tested here
Drugs under test in Hereditary Breast and Ovarian Cancer Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Veliparib | 0 | 0 | 2 |
| Letrozole | 0 | 1 | 1 |
| Zoledronic Acid | 0 | 0 | 1 |
| Carboplatin | 0 | 0 | 1 |
| Docetaxel | 0 | 0 | 1 |
| Arzoxifene hydrochloride | 0 | 0 | 1 |
| Tamoxifen | 0 | 0 | 1 |
| Prexasertib | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5
- Dec 2026Triple Negative Breast Cancer and Germline Hereditary Breast and Ovarian Cancer Mutation Carrier Registry · University of Kansas Medical Center
- Dec 2026Investigation of Tumour Spectrum of Germline Mutations in Breast and Ovarian Cancer Genes. · UNICANCER
- Jun 2027The FYI on MRI: A Multilevel Decision Support Intervention for Screening Breast MRI · Georgetown University
- Sep 2027PreCharge: An Innovative Digital Program to Increase Coping, Resilience, and Health Care Engagement Among Cancer Previvors · Pro-Change Behavior Systems
- Oct 2027Feasibility Study: IGNITE-TX (Identifying Individuals for Genetic Testing & Treatment) Intervention · M.D. Anderson Cancer Center
Who these studies take
Of the 9 Hereditary Breast and Ovarian Cancer Syndrome studies recruiting now, 6 (67%) set no upper age limit and 1 (11%) stop at 75 or younger. 3 (33%) take children under 18. 4 (44%) are for women only and 0 (0%) for men only; 3 (33%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (33%) | 3 (33%) |
| 18 | 9 (100%) | 5 (56%) |
| 30 | 9 (100%) | 5 (56%) |
| 40 | 9 (100%) | 5 (56%) |
| 50 | 9 (100%) | 5 (56%) |
| 65 | 9 (100%) | 5 (56%) |
| 75 | 8 (89%) | 5 (56%) |
| 85 | 7 (78%) | 5 (56%) |
Across all 62 studies, recruiting or not: 18% stop at 75 or younger and 8% at 65; 16% take children; 60% are for women only and 0% for men only; 34% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hereditary Breast and Ovarian Cancer Syndrome studies take
Of 22 interventional studies with no phase under Hereditary Breast and Ovarian Cancer Syndrome, half reached primary completion within 55 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 55 mo31–… · 22 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 16, 2026.
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 62. Browse all 62 → or search them.
- PreCharge: An Innovative Digital Program to Increase Coping, Resilience, and Health Care Engagement Among Cancer PrevivorsNot yet recruitingNCT07936682Not applicable
- Ovarian Cancer Liquid Biopsy for Early Assessment & Detection in Individuals With BRCA1/2 Pathogenic VariantsNot yet recruitingNCT07764744Not applicable1 country
- CfDNA in Hereditary And High-risk Malignancies 2RecruitingNCT067266421 country
- Triple Negative Breast Cancer and Germline Hereditary Breast and Ovarian Cancer Mutation Carrier RegistryRecruitingNCT023027421 country
- Identifying and Caring for Individuals With Inherited Cancer SyndromeRecruitingNCT04494945Not applicable1 country
- Patient Centered Clinical Decision Support for Hereditary Cancer SyndromesEnrolling by invitationNCT06914726Not applicable1 country
- Familial Investigations of Childhood Cancer PredispositionRecruitingNCT030502681 country
- Cascade Genetic Testing for Hereditary Breast/Ovarian Cancer and Lynch Syndrome in SwitzerlandRecruitingNCT031242121 country
- Evaluation of Well Being and Patient Reported Outcomes After Robotic Single-port Nipple Sparing Mastectomy and Implant ReconstructionNot yet recruitingNCT07236359Not applicable
- The FYI on MRI: A Multilevel Decision Support Intervention for Screening Breast MRIRecruitingNCT06892275Not applicable1 country
- Development and Validation of an Ovarian Cancer Risk Prediction Model for Family Members of Ovarian Cancer ProbandsRecruitingNCT070395521 country
- Specimen and Data Study for Ovarian Cancer Early Detection and PreventionRecruitingNCT000050951 country
- Efficacy of Lifestyle Intervention in BRCA1/2 Mutation CarriersRecruitingNCT02516540Not applicable1 country
- CONTIGO - A Narrative Intervention to Enhance Genetic Counseling and TestingCompletedNCT05130606Not applicable1 country
- Feasibility Study: IGNITE-TX (Identifying Individuals for Genetic Testing & Treatment) InterventionActive, not recruitingNCT05677048Not applicable1 country
- Investigation of Tumour Spectrum of Germline Mutations in Breast and Ovarian Cancer Genes.Active, not recruitingNCT03246841Not applicable1 country
- Surgery in Preventing Ovarian Cancer in Patients With Genetic MutationsActive, not recruitingNCT02760849Not applicable1 country
- Sequential EHR Based Interventions to Increase Genetic Testing for Breast and Ovarian Cancer PredispositionCompletedNCT05721326Not applicable1 country
- Pediatric Reporting of Adult-Onset Genomic ResultsCompletedNCT03832985Early Phase 11 country
- Scalable Communication Modalities for Returning Genetic Research ResultsCompletedNCT04407611Not applicable1 country
- Radical Fimbriectomy for Young BRCA Mutation CarriersActive, not recruitingNCT01608074Not applicable1 country
- Cancer Genetics Hereditary Cancer Panel TestingCompletedNCT023240621 country
- Cell-free DNA in Hereditary And High-Risk Malignancies 1Active, not recruitingNCT042619721 country
- Cancer Health Assessments Reaching ManyCompletedNCT03426878Not applicable1 country
- Women at Risk of Breast Cancer and OLFM4Active, not recruitingNCT02653105Not applicable1 country
- Clinical Impact of Enhanced Risk Assessments in Women With a BRCA1/2 Mutation, CARE StudyCompletedNCT06534424Not applicable1 country
- Genetics and Heart Health After Cancer TherapyCompletedNCT035106891 country
- Cost of Cancer Risk Management in Women at Elevated Genetic Risk for Ovarian Cancer Who Participated on GOG-0199WithdrawnNCT014452751 country
- Direct Information to At-risk RelativesActive, not recruitingNCT04197856Not applicable1 country
- Letrozole in Preventing Breast Cancer in Postmenopausal Women With a BRCA1 or BRCA2 MutationCompletedNCT00673335Phase 31 country
- Feasibility of Lifestyle Intervention in BRCA1/2 Mutation CarriersCompletedNCT02087592Not applicable1 country
- Implementation of the Families Accelerating Cascade Testing Toolkit (FACTT) for Hereditary Breast and Ovarian Cancer and Lynch SyndromeTerminatedNCT04508764Not applicable1 country
- Nutritional Intervention and DNA Damage of Patients With HBOCCompletedNCT05306002Not applicable1 country
- Multifactorial Risk Assessment for Breast & Ovarian Cancer Risk DetectionTerminatedNCT046685211 country
- Neoadjuvant Carboplatin in Triple Negative Breast CancerCompletedNCT02978495Phase 21 country
- A Phase II Single Arm Pilot Study of the Chk1/2 Inhibitor (LY2606368) in BRCA1/2 Mutation Associated Breast or Ovarian Cancer, Triple Negative Breast Cancer, High Grade Serous Ovarian Cancer, and Metastatic Castrate-Resistant Prostate CancerTerminatedNCT02203513Phase 21 country
- Study of Quality of Life Post Salpingo-oophorectomy in BRCA1/2 & PALB2 Mutation Carriers (BRCA-HRT)Status unknownNCT054092221 country
- Enhance the Use of Genetic Counseling and Testing in LatinasCompletedNCT04544501Not applicable1 country
- Testing an Intelligent Tutoring System to Enhance Genetic Risk AssessmentCompletedNCT03511690Not applicable1 country
- Impact of a Psychoeducational Intervention on Expectations and Coping in Young Women Exposed to a High HBOC RiskTerminatedNCT02705924Not applicable1 country
- Statewide Communication to Reach Diverse Low Income WomenCompletedNCT02956681Not applicable
- Tissue Expansion in Breast Reconstruction Without DrainsCompletedNCT037848591 country
- Zoledronate or Observation in Maintaining Bone Mineral Density in Patients Who Are Undergoing Surgery to Remove Both OvariesCompletedNCT00305695Phase 21 country
- Enhancing At-risk Latina Women's Use of Genetic Counseling for Hereditary Breast and Ovarian CancerCompletedNCT03075540Not applicable1 country
- Genetic Counseling for Breast Cancer Survivors (GC for BC)CompletedNCT02451735Not applicable1 country
- Evaluation of the Adhesion to the GENEPY NetworkStatus unknownNCT039796121 country
- Genetic Risk: Whether, When, and How to Tell AdolescentsCompletedNCT034213271 country
- Inherited Susceptible Genes Among Epithelial Ovarian CancerStatus unknownNCT030153761 country
- Trial of Inquiry Based Stress Reduction (IBSR) Program for BRCA1/2 Mutation CarriersStatus unknownNCT03162276Phase 31 country
- Veliparib in Treating Patients With Malignant Solid Tumors That Do Not Respond to Previous TherapyCompletedNCT00892736Phase 11 country