Meningeal Neoplasms clinical trials
The registry lists 40 studies for Meningeal Neoplasms across more than 10 countries. 17 are recruiting or about to start. 13 of them are mainly about Meningeal Neoplasms (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13. Counting its 2 narrower conditions too, such as Meningioma: 427 studies, 145 open.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
M.D. Anderson Cancer Center (7) · H. Lee Moffitt Cancer Center and Research Institute (4) · National Cancer Institute (NCI) (3) · Sunnybrook Health Sciences Centre (2) · University Hospital Tuebingen (2) · Memorial Sloan Kettering Cancer Center (2) · British Columbia Cancer Agency (1) · MedSIR (1)
What is being tested here
Drugs under test in Meningeal Neoplasms studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Trastuzumab | 2 | 0 | 4 |
| Tucatinib | 2 | 0 | 3 |
| Capecitabine | 2 | 0 | 3 |
| Nivolumab | 1 | 0 | 2 |
| Rhenium Re 186 Obisbemeda | 1 | 0 | 1 |
| Methotrexate | 1 | 0 | 1 |
| SX-682 | 1 | 0 | 1 |
| Gadopiclenol | 1 | 0 | 1 |
| Gadobutrol | 1 | 0 | 1 |
| Mafosfamide | 0 | 0 | 2 |
Drug classes tested here Antimetabolites 3 open · Tyrosine kinase inhibitors (TKIs) 2 open · Immune checkpoint inhibitors 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Dec 2026Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis · Wake Forest University Health Sciences
- Dec 2026Exploring the Feasibility of Cerebrospinal Fluid (CSF) and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and Primary Central Nervous System (CNS) Tumours: A Pilot Study · Sunnybrook Health Sciences Centre
- Dec 2026Capecitabine, Tucatinib, and Intrathecal Trastuzumab for Breast Cancer Patients With Leptomeningeal Disease · UNICANCER
- Dec 2026Standardized Clinical Assessment of Patients With Leptomeningeal Metastasis · University of Zurich
- Dec 2026Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-Oncology · M.D. Anderson Cancer Center
- Dec 2026Tucatinib, Trastuzumab and Capecitabine With Brain and/or Spinal Radiotherapy (XRT) in Patients With HER2+, HER2 Mutated and/or HER2-amplified Metastatic Breast Cancer and Leptomeningeal Disease: A Multi-centre Phase II, Single Arm Feasibility Study · Sunnybrook Health Sciences Centre
- Dec 2026Intrathecal Application of PD1 Antibody in Metastatic Solid Tumors With Leptomeningeal Disease (IT-PD1/ NOA 26) · University Hospital Tuebingen
- Apr 2027Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease · H. Lee Moffitt Cancer Center and Research Institute
- Jun 2027Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease · M.D. Anderson Cancer Center
- Jul 2027Multiple Dose Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases · Cerenome
Who these studies take
Of the 15 Meningeal Neoplasms studies recruiting now, 14 (93%) set no upper age limit and 1 (7%) stop at 75 or younger. 1 (7%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (7%) | 1 (7%) |
| 18 | 15 (100%) | 15 (100%) |
| 30 | 14 (93%) | 14 (93%) |
| 40 | 14 (93%) | 14 (93%) |
| 50 | 14 (93%) | 14 (93%) |
| 65 | 14 (93%) | 14 (93%) |
| 75 | 14 (93%) | 14 (93%) |
| 85 | 14 (93%) | 14 (93%) |
Across all 40 studies, recruiting or not: 5% stop at 75 or younger and 3% at 65; 20% take children; 0% are for women only and 0% for men only; 3% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 14, 2026.
Results posted1
- Study Assessing QBS72S For Treating Brain MetastasesOct 20, 2026NCT05305365
Studies
Recruiting first, then most recently updated. Showing 40 of 40. search them.
- Multiple Dose Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal MetastasesRecruitingNCT07098806Phase 1/21 country
- Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal MetastasisRecruitingNCT02422641Phase 21 country
- CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal DiseaseRecruitingNCT05257967Not applicable1 country
- Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-OncologyRecruitingNCT049880091 country
- A Study of SX-682 in Combination With Proton Craniospinal Irradiation (pCSI) in People With Leptomeningeal DiseaseRecruitingNCT07814352Phase 11 country
- B7-H3.CD28Z.CART in CNS NeoplasmsRecruitingNCT07390539Phase 11 country
- Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade GliomaNot yet recruitingNCT07751744Phase 1/2
- Exploring the Feasibility of Cerebrospinal Fluid (CSF) and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and Primary Central Nervous System (CNS) Tumours: A Pilot StudyRecruitingNCT07476781Not applicable1 country
- Trial of Therapies With IT cDC1s Combined w/ IT Trastuzamab for Her+ or IT Nivolumab for Her- BC LMDRecruitingNCT07694986Phase 21 country
- ctDNA-Guided Intraventricular Therapy for CNS MalignanciesNot yet recruitingNCT07689721Not applicable
- Optimizing Contrast Dose and Scanning Parameters for Detection of Leptomeningeal DiseaseRecruitingNCT07415018Not applicable1 country
- Non Interventional German Leptomeningeal Disease RegisterRecruitingNCT061460101 country
- Tucatinib, Trastuzumab and Capecitabine With Brain and/or Spinal Radiotherapy (XRT) in Patients With HER2+, HER2 Mutated and/or HER2-amplified Metastatic Breast Cancer and Leptomeningeal Disease: A Multi-centre Phase II, Single Arm Feasibility StudyRecruitingNCT06016387Phase 21 country
- Capecitabine, Tucatinib, and Intrathecal Trastuzumab for Breast Cancer Patients With Leptomeningeal DiseaseRecruitingNCT05800275Phase 21 country
- Neoadjuvant Stereotactic Radiotherapy for Brain MetastasisRecruitingNCT06933199Not applicable1 country
- Intrathecal Application of PD1 Antibody in Metastatic Solid Tumors With Leptomeningeal Disease (IT-PD1/ NOA 26)RecruitingNCT05112549Phase 11 country
- Standardized Clinical Assessment of Patients With Leptomeningeal MetastasisRecruitingNCT064177103 countries
- Testing of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung CancerActive, not recruitingNCT04250545Phase 11 country
- Study Assessing QBS72S For Treating Brain MetastasesActive, not recruitingNCT05305365Phase 21 country
- A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain CancerCompletedNCT03423628Phase 13 countries
- A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV)Active, not recruitingNCT05809752Phase 11 country
- Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal DiseaseActive, not recruitingNCT03025256Phase 11 country
- Lymphodepletion Plus Adoptive Cell Transfer With or Without Dendritic Cell Immunization in Patients With Metastatic MelanomaActive, not recruitingNCT00338377Phase 21 country
- Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal DiseaseActive, not recruitingNCT04588545Phase 1/21 country
- HER3-DXd in Breast Cancer and NSCLC Brain Metastases and Solid Tumor Leptomeningeal DiseaseCompletedNCT05865990Phase 22 countries
- Avelumab With Radiotherapy in Patients With Leptomeningeal DiseaseCompletedNCT03719768Phase 11 country
- Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMDTerminatedNCT03501979Phase 21 country
- 131I-omburtamab for the Treatment of Central Nervous System/Leptomeningeal Neoplasms in Children and Young AdultsNo longer availableNCT050643061 country
- A Therapy Treatment Response Trial in Patients With Leptomeningeal Metastases ((LM) Using CNSideTerminatedNCT054141231 country
- ANG1005 in Leptomeningeal Disease From Breast CancerStatus unknownNCT03613181Phase 3
- Afatinib on CNS Metastases and LMD in EGFR Mutation Positive NSCLCTerminatedNCT03711422Phase 11 country
- Intrathecal MafosfamideCompletedNCT00062881Phase 11 country
- Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous SystemTerminatedNCT01596127Phase 1/21 country
- RTA 744 Injection in Patients With Leptomeningeal DiseaseTerminatedNCT00512460Phase 11 country
- Decision Making About Participating in Pharmacokinetic Studies in Patients Enrolled in a Phase I Treatment Clinical TrialCompletedNCT00890435
- Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United KingdomStatus unknownNCT007576141 country
- Phase I Study of Intrathecal MafosfamideCompletedNCT00001251Phase 11 country
- DepoCyt Plus Temozolomide in Patients With Neoplastic MeningitisTerminatedNCT00515788Phase 11 country
- Phase I Study of Intrathecal TopotecanCompletedNCT00001333Phase 11 country
- DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid TumorCompletedNCT00029523Phase 42 countries