SX-682 clinical trials
Also written SX-682.
How each study uses SX-682 is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Get an email when these change. Save the SX-682 studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Approvals
The first approval found in each region, with its record
- United States
- Not in FDA's approval records
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
13 studies that test it; most in 2020 (4)
| Year | Studies |
|---|---|
| 2019 | 1 |
| 2020 | 4 |
| 2023 | 2 |
| 2024 | 1 |
| 2025 | 2 |
| 2026 | 3 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 3 · Other 10
Syntrix Biosystems, Inc. (3) · National Cancer Institute (NCI) (2) · University of Washington (2) · M.D. Anderson Cancer Center (1) · University of Rochester (1) · Lei Zheng (1) · Memorial Sloan Kettering Cancer Center (1) · Institute of Cancer Research, United Kingdom (1)
Often tested with
Tested in the same studies.
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 3
Studies that test SX-682.
- Apr 2027SX-682 in Combination With Carfilzomib, Daratumumab-Hyaluronidase, and Dexamethasone in Patients With Relapsed or Refractory Multiple MyelomaPhase 1 · Roswell Park Cancer Institute
- Jun 2027Study of SX-682 Plus Enzalutamide in Men With ARPI-Resistant Metastatic Castration Resistant Prostate CancerPhase 2 · Syntrix Biosystems, Inc.
- Jul 2027SX-682 With Pembrolizumab for the Treatment of Metastatic or Recurrent Stage IIIC or IV Non-Small Cell Lung CancerPhase 2 · University of Washington
Studies
Open first, then newest update. How each study uses SX-682 is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 13
- Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate CancerRecruitingPhase 1/2National Cancer Institute (NCI)NCT07667400Written as SX-682
- SX-682 and Atezolizumab for the Treatment of Advanced or Metastatic, Recurrent Non-small Cell Lung CancerRecruitingPhase 2University of WashingtonNCT07322341Written as CXCR1/2 Inhibitor SX-682
- A Neoadjuvant Study of Tislelizumab and SX-682 for Resectable Pancreas CancerRecruitingPhase 2Lei ZhengNCT05604560Written as SX-682
- A Study of SX-682 in Combination With Proton Craniospinal Irradiation (pCSI) in People With Leptomeningeal DiseaseRecruitingPhase 1Memorial Sloan Kettering Cancer CenterNCT07814352Written as SX-682
- Investigating SX-682 in Combination With Apalutamide in Metastatic Castration-resistant Prostate CancerRecruitingPhase 1/2Institute of Cancer Research, United KingdomNCT07002320Written as SX-682
- SX-682 in Combination With Carfilzomib, Daratumumab-Hyaluronidase, and Dexamethasone in Patients With Relapsed or Refractory Multiple MyelomaRecruitingPhase 1Roswell Park Cancer InstituteNCT06622005Written as Cxcr1/2 Inhibitor SX-682
- SX-682 With Pembrolizumab for the Treatment of Metastatic or Recurrent Stage IIIC or IV Non-Small Cell Lung CancerRecruitingPhase 2University of WashingtonNCT05570825Written as CXCR1/2 Inhibitor SX-682
- Study of SX-682 Plus Enzalutamide in Men With ARPI-Resistant Metastatic Castration Resistant Prostate CancerRecruitingPhase 2Syntrix Biosystems, Inc.NCT06228053Written as SX-682
- Study of SX-682 Alone and in Combination With Oral or Intravenous Decitabine in Subjects With Myelodysplastic SyndromeRecruitingPhase 1Syntrix Biosystems, Inc.NCT04245397Written as SX-682
- SX-682 and Nivolumab for the Treatment of RAS-Mutated, MSS Unresectable or Metastatic Colorectal Cancer, the STOPTRAFFIC-1 TrialActive, not recruitingPhase 1/2M.D. Anderson Cancer CenterNCT04599140Written as CXCR1/2 Inhibitor SX-682
- A Study to Evaluate the Safety and Tolerability of SX-682 in Combination With Nivolumab as a Maintenance Therapy in Patients With Metastatic Pancreatic Ductal AdenocarcinomaActive, not recruitingPhase 1University of RochesterNCT04477343Written as SX-682
- SX-682 Treatment in Subjects With Metastatic Melanoma Concurrently Treated With PembrolizumabActive, not recruitingPhase 1Syntrix Biosystems, Inc.NCT03161431Written as SX-682
- Phase I/II Trial Investigating the Safety, Tolerability, Pharmacokinetics, Immune and Clinical Activity of SX-682 in Combination With BinTrafusp Alfa (M7824 or TGF-beta "Trap"/PD-L1) With CV301 TRICOM in Advanced Solid Tumors (STAT)CompletedPhase 1/2National Cancer Institute (NCI)NCT04574583Written as SX-682