Mastodynia clinical trials
The registry lists 44 studies for Mastodynia across more than 10 countries. 10 are recruiting or about to start. 28 of them are mainly about Mastodynia (how this is decided). Per ClinicalTrials.gov, last updated 2026-09-17.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Mayo Clinic (3) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (2) · Duke University (2) · University of California, San Diego (2) · University of Houston (2) · Mountain States Tumor and Medical Research Institute (1) · University of California, San Francisco (1) · Nigde Omer Halisdemir University (1)
What is being tested here
Drugs under test in Mastodynia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Bupivacaine | 0 | 0 | 1 |
| Liposomal Bupivacaine | 0 | 0 | 1 |
| Lidoderm | 0 | 0 | 1 |
| Lidocaine | 0 | 0 | 1 |
| Tamoxifen | 0 | 0 | 1 |
| Evening primrose oil | 0 | 0 | 1 |
| Danazol | 0 | 0 | 1 |
| Toremifene | 0 | 1 | 1 |
| Diclofenac | 0 | 1 | 1 |
| Omega-3 fatty acid | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3, phase 3 first
- Jun 2027External Mastalgia-oil Versus Placebo in Premenopausal Women With Severe Mastalgia · Phase 3 · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Dec 2026Comparison of the Postoperative Analgesic Efficacy of SAP and SPSIP Blocks in Patients Undergoing Mammoplasty · Abant Izzet Baysal University
- Aug 2027ATUSA Ultrasound Diagnostic Imaging for Breast Lesions Evaluation (AUDIBLE) - iSono Health · iSono Health, Inc.
Who these studies take
Of the 7 Mastodynia studies recruiting now, 1 (14%) set no upper age limit and 4 (57%) stop at 75 or younger. 0 (0%) take children under 18. 6 (86%) are for women only and 0 (0%) for men only; 1 (14%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 7 (100%) | 1 (14%) |
| 30 | 7 (100%) | 1 (14%) |
| 40 | 7 (100%) | 1 (14%) |
| 50 | 6 (86%) | 1 (14%) |
| 65 | 4 (57%) | 1 (14%) |
| 75 | 3 (43%) | 1 (14%) |
| 85 | 2 (29%) | 1 (14%) |
Across all 44 studies, recruiting or not: 45% stop at 75 or younger and 41% at 65; 7% take children; 91% are for women only and 0% for men only; 25% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 44 of 44. search them.
- ATUSA Ultrasound Diagnostic Imaging for Breast Lesions Evaluation (AUDIBLE) - iSono HealthRecruitingNCT075057971 country
- Hormones, Outcomes, and Pain Pathways in Exercise StudyRecruitingNCT07579182Phase 11 country
- Local Treatment of Breast Pain Based on the Daily Use of a Topical GelRecruitingNCT07257770Not applicable1 country
- External Mastalgia-oil Versus Placebo in Premenopausal Women With Severe MastalgiaRecruitingNCT06966245Phase 31 country
- Comparison of the Postoperative Analgesic Efficacy of SAP and SPSIP Blocks in Patients Undergoing MammoplastyNot yet recruitingNCT07302399Not applicable1 country
- Study on the Effects of Acupuncture in Patients with Cyclic MastalgiaNot yet recruitingNCT06713980Not applicable
- External Mastalgia-oil Versus Oral Tamoxifen in Premenopausal Women with Severe MastalgiaNot yet recruitingNCT06404775Phase 31 country
- Effectiveness of Acupuncture for Cyclical Mastalgia （CM）RecruitingNCT05408377Not applicable1 country
- Serratus and Parasternal Infrapectoral Block for Breast Surgery.RecruitingNCT03708302Not applicable1 country
- Predicting Chronic Pain Following Breast SurgeryRecruitingNCT049673521 country
- A New Treatment Option for MastalgiaCompletedNCT06168110Not applicable1 country
- Comparing Sports Bra Design in Full Busted WomenCompletedNCT05456594Not applicable1 country
- Pattern of Clinical Presentation of Different Breast Disease in Surgical Opd at BPKIHSCompletedNCT060261761 country
- Study of Afimoxifene Gel to Treat Cyclic Mastalgia in Premenopausal WomenCompletedNCT00272714Phase 2
- Acupuncture for Breast PainStatus unknownNCT05548374Not applicable1 country
- The Impact of Pecs Blocks on Postmastectomy Pain SyndromeCompletedNCT04586751Not applicable2 countries
- Focal Breast Pain: Does a Normal Ultrasound Provide Reassurance?CompletedNCT02810236Not applicable1 country
- The Use Of Liposomal Bupivacaine For Pain ControlCompletedNCT03722927Phase 41 country
- e-Nature VR: Evaluation of the Impact of Virtual Reality During Breast BiopsyTerminatedNCT03877094Not applicable1 country
- Mastalgia Treatment: Is There a Role for Osteopathic Manipulative TreatmentWithdrawnNCT01643837Not applicable1 country
- Comparative Analysis of Three Locoregional Anesthesia Methods in Breast Tumour Pathology SurgeryCompletedNCT05185752Not applicable1 country
- Evaluation of Sleep Quality, Nutrition, Anxiety and Depression in MastalgiaCompletedNCT046902181 country
- Cryoablation for Post Mastectomy Pain SyndromeCompletedNCT03293940Not applicable1 country
- Breastfeeding Self-Management for Nipple and Breast PainCompletedNCT03392675Not applicable1 country
- Omega-3 Fatty Acids Plus Vitamin E Cosupplementation Versus Vitamin E in Fibrocystic Breast PatientStatus unknownNCT04694027Phase 41 country
- Calming Alternatives Learned During MRI-Guided Breast BiopsyCompletedNCT03877146Not applicable1 country
- Ropivacaine 0,2% Plus Dexamethasone Versus Ropivacaine 0,2% Plus Placebo in Modified Pectoral BlockStatus unknownNCT03700177Phase 41 country
- Post Mastectomy Pain Syndrome After Preoperative Stellate Ganglion Block for Breast Cancer SurgeriesStatus unknownNCT04238377Not applicable1 country
- A Breast Support Intervention for Women With Breast PainCompletedNCT02515253Not applicable1 country
- Evaluation of an Educational Intervention for Women With Breast PainStatus unknownNCT03936842Not applicable1 country
- Symptom Management After Breast Cancer SurgeryCompletedNCT00686127Phase 41 country
- Electromyography of the Pectoral Muscle in Mastalgia PatientsCompletedNCT027843791 country
- Efficacy and Safety of 20 mg (2 Tablets of 10mg)VAC BNO 1095 FCT on Cyclic Mastodynia and PMSTerminatedNCT01870687Phase 31 country
- Local Anesthetic for Total Mastectomy SurgeryStatus unknownNCT02893384Phase 4
- Prevention of Post-Mastectomy Breast Pain Using Ambulatory Continuous Paravertebral BlocksCompletedNCT01231204Phase 41 country
- Acupuncture for Non-cyclical Breast PainCompletedNCT00275574Not applicable1 country
- Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast CancerCompletedNCT00999921Phase 41 country
- L.Fermentum CECT5716 in Treatment of Breast PainCompletedNCT02093338Not applicable1 country
- Treatment of Breast Pain Using A Medication (Diclofenac) Applied to the SkinTerminatedNCT00276419Phase 2/31 country
- A Study of Topical Danazol for the Treatment of Pain Associated With Fibrocystic Breast DiseaseCompletedNCT00744276Phase 21 country
- Randomized Clinical Trial of Vitamin E and Evening Oil of Primrose for the Managment of Breast PainCompletedNCT00275600Phase 2/31 country
- The Effect of Toremifene Treatment to the Magnetic Resonance Imaging (MRI) Findings in Premenstrual MastalgiaCompletedNCT00534846Phase 31 country
- Study for Treatment of Moderate or Severe, Periodic, "Cyclic", Breast PainStatus unknownNCT00237523Phase 31 country
- Premedication to Reduce Discomfort With Screening MammographyCompletedNCT00382083Phase 41 country