Lymphedema clinical trials
The registry lists 529 studies for Lymphedema across more than 10 countries. 131 are recruiting or about to start. 320 of them are mainly about Lymphedema (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 3 narrower conditions too, such as Breast Cancer Lymphedema: 647 studies, 158 open.
ClinicalTrials.gov finds 722 studies for Lymphedema. How that becomes 529 here
This page counts the studies the registry files under Lymphedema, and those it files under no condition that list Lymphedemathemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 722Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −117Filed under a narrower condition, counted on its own pageBreast Cancer Lymphedema 74 · Elephantiasis, Filarial 38 · Elephantiasis 5
- −36List Lymphedema as a condition, but the registry did not file them under itMost often written as “Lymphedema of Upper Arm” (4), “Lymphedema Arm” (4), and “Secondary Lymphedema” (3). The registry filed them under other conditions only, most often Breast Neoplasms (18) and Head and Neck Neoplasms (4).
- −40Match it another way32 name it in the title, 5 in a keyword, and 3 by a synonym or other text the search reads.
- 529The count on this page45 of them list Lymphedema in their own words; the registry filed them under no condition.
Get an email when these change. Save the Lymphedema studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
Chang Gung Memorial Hospital (12) · Stanford University (12) · Cairo University (11) · Tactile Medical (10) · Vanderbilt University (9) · Memorial Sloan Kettering Cancer Center (9) · Odense University Hospital (8) · Universitaire Ziekenhuizen KU Leuven (8)
What is being tested here
Drugs under test in Lymphedema studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Inelastic Compression Use in Primary Lymphedema · University School of Physical Education, Krakow, Poland
- Nov 2026Effectiveness of a Tele-Rehabilitation-Based Exercise and Self-Lymphatic Drainage Program Supported by Self-Management for Breast Cancer-Related Lymphedema · Istanbul University
- Nov 2026PREVENT: PeRomEter Visualization to ENd Treatment-related Lymphedema · M.D. Anderson Cancer Center
- Dec 2026Prospective Surveillance for Breast Cancer-Related Lymphedema · Rigshospitalet, Denmark
- Dec 2026Comparison of the Effects of Kinesio Taping and Compression Bandaging on Edema, Range of Motion, Upper Extremity Function, and Grip Strength in Patients With Breast Cancer-Related Lymphedema · Halic University
- Dec 2026The BEACON Trial: Diagnostic Tools for Breast Lymphedema After Treatment for Breast Cancer · Massachusetts General Hospital
- Dec 2026Aerobic Exercise Effects in Lower Extremity Lymphedema · Bursa Yuksek Ihtisas Training and Research Hospital
- Dec 2026Sahid Method for Secondary Unilateral Lower Limb Lymphedema · University Diego Portales
- Dec 2026Lymphaticovenous Anastomosis as Treatment for Lymphedema · Odense University Hospital
- Dec 2026Effect of Preoperative Rehabilitation Exercise on Improving Postoperative Lymphedema, Quality of Life and Care Needs in Patients With Breast Cancer Surgery · National Taiwan University Hospital
Who these studies take
Of the 85 Lymphedema studies recruiting now, 46 (54%) set no upper age limit and 21 (25%) stop at 75 or younger. 5 (6%) take children under 18. 30 (35%) are for women only and 0 (0%) for men only; 12 (14%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (6%) | 4 (5%) |
| 18 | 68 (80%) | 46 (54%) |
| 30 | 80 (94%) | 52 (61%) |
| 40 | 81 (95%) | 53 (62%) |
| 50 | 83 (98%) | 54 (64%) |
| 65 | 80 (94%) | 53 (62%) |
| 75 | 74 (87%) | 52 (61%) |
| 85 | 56 (66%) | 44 (52%) |
Across all 529 studies, recruiting or not: 26% stop at 75 or younger and 14% at 65; 9% take children; 49% are for women only and <1% for men only; 16% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Lymphedema studies take
Of 197 interventional studies with no phase under Lymphedema, half reached primary completion within 25 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 25 mo9–64 · 197 studies | — | 27 mo10–68 · 175 studies |
| Observational | 45 mo12–108 · 59 studies | — | 45 mo12–108 · 56 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered5
- Comparison of Reliability, Time Cost, and Participant Comfort of Lymphedema Assessments in Upper ExtremityNov 6, 2026NCT07921290
- Comparison of the Effects of Kinesio Taping and Compression Bandaging on Edema, Range of Motion, Upper Extremity Function, and Grip Strength in Patients With Breast Cancer-Related LymphedemaNov 5, 2026NCT07919093
- Ultrasonographic Tissue Thickness After Complex Decongestive Therapy in Lower-Limb LymphedemaNov 5, 2026NCT07919834
- Use of Reconstructive Microsurgery for the Treatment of LymphedemaOct 22, 2026NCT07889856
- Efficacy of Complete Decongestive Therapy for Limb Lymphedema: Response Profile and Predictive ModelingOct 16, 2026NCT07878598
Studies
Recruiting first, then most recently updated. Showing 50 of 529. Browse all 529 → or search them.
- Screening For BCRL In Targeted Therapy For Breast CancerRecruitingNCT051428001 country
- Prospective Screening for Breast Cancer-related LymphedemaRecruitingNCT015217411 country
- A Study of a Comprehensive Prevention Program to Reduce Lymphedema After Axillary Lymph Node Dissection in People With Breast CancerRecruitingNCT06144164Phase 31 country
- Self-Management for Head and Neck Lymphedema and Fibrosis [PROMISE Trial]RecruitingNCT06125743Not applicable1 country
- Comparison of Reliability, Time Cost, and Participant Comfort of Lymphedema Assessments in Upper ExtremityNot yet recruitingNCT07921290
- Comparison of the Effects of Kinesio Taping and Compression Bandaging on Edema, Range of Motion, Upper Extremity Function, and Grip Strength in Patients With Breast Cancer-Related LymphedemaEnrolling by invitationNCT07919093Not applicable1 country
- A Post-market, Real-world Experience: Expanding Access to Care by Incorporating the Symani® Surgical System and Enabling SurgeonsRecruitingNCT067250301 country
- Lymphovenous Bypass Procedure for Secondary Prevention of Lymphedema in Breast CancerRecruitingNCT07233863Not applicable1 country
- A Prospective Natural History Study of Lymphatic AnomaliesRecruitingNCT057311411 country
- Use of Reconstructive Microsurgery for the Treatment of LymphedemaRecruitingNCT078898561 country
- Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary SurgeryRecruitingNCT07140172Not applicable11 countries
- Inelastic Compression Use in Primary LymphedemaNot yet recruitingNCT07866599Not applicable
- Preventing Lymphedema in Patients Undergoing Surgical Treatment for Head and Neck Cancer Through Vein ReconstructionRecruitingNCT07694726Not applicable1 country
- Biorepository of Biomarkers for Optimization of Microvascular Treatment of LymphedemaEnrolling by invitationNCT041234571 country
- Prediction Of Lymphedema In Patients With Inflammatory BreastCancer Using Preoperative Bioimpedance MeasurementsRecruitingNCT078556271 country
- Pregnancy in Women With Rare Multisystemic Vascular Diseases: COGRare5 StudyRecruitingNCT041946191 country
- Lymphedema Prevention Through Immediate Lymphatic Reconstruction (LILY) Trial.RecruitingNCT06989099Phase 21 country
- A Study Comparing Quality of Life in Patients With Lymphedema Who Undergo Surgical Treatment Versus Non-Surgical ManagementRecruitingNCT032483101 country
- Evaluation of Adherence to Rehabilitation: Autonomous and Guided, in the Observation and Treatment Response of Head and Neck Lymphedema in Neoplasms During RadiotherapyNot yet recruitingNCT07838857Not applicable
- Effect of Resisted Deep Breathing and Myofascial Release in PostmastectomyRecruitingNCT07576270Not applicable1 country
- The Effect of Resistance Exercise in Patients With Lower Limb Lymphedema (the LymphEx Study)RecruitingNCT07558317Not applicable1 country
- Extracorporeal Shock Wave Therapy in Lower Extremity LymphedemaRecruitingNCT07626645Not applicable1 country
- Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)RecruitingNCT06494111Phase 21 country
- Gut Microbiota in Patients With Limb Lymphedema and Recurrent LymphangitisRecruitingNCT062289371 country
- Testing for Increased Lipoproteins (a) [LP(a)] in Lymphedema Patients: Li-LYRecruitingNCT05962827Not applicable1 country
- Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Postoperative Pain After MastectomyEnrolling by invitationNCT05444361Not applicable1 country
- Biological Profile of Primary and Secondary Lymphedema: Inflammatory, Endothelial, Metabolic, Lymphatic, and Fibrotic MarkersNot yet recruitingNCT077703991 country
- LYMPHA Procedure for the Prevention of Lymphedema After Axillary LymphadenectomyRecruitingNCT05366699Not applicable1 country
- Evaluate Advanced Pneumatic Compression Device With Revised Compression Programming for Lymphedema TreatmentRecruitingNCT07613931Early Phase 11 country
- IIT2023-09-Chung-UpfrontTAD: Upfront TAD/SNB in Patients With Breast Cancer With Nodal MetastasesRecruitingNCT06092892Phase 21 country
- Effect of Preoperative Rehabilitation Exercise on Improving Postoperative Lymphedema, Quality of Life and Care Needs in Patients With Breast Cancer SurgeryRecruitingNCT07743294Not applicable1 country
- Aerobic Exercise Effects in Lower Extremity LymphedemaNot yet recruitingNCT07726277Not applicable
- Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)RecruitingNCT06912763Phase 21 country
- Boosted Compression for Lower Limb Chronic EdemaRecruitingNCT07708662Not applicable1 country
- Advancing Patient Care for Lymphatic Pain and LymphedemaNot yet recruitingNCT07701018Not applicable1 country
- Respiratory and Relaxation Training in Lower Extremity LymphedemaRecruitingNCT07697482Not applicable1 country
- Scapulothoracic Stabilization and Postural Training in Upper Extremity LymphedemaRecruitingNCT07697495Not applicable1 country
- Clinical Lymphedema Evaluation - Advancing Reconstruction of Head and Neck Lymphatics With SymaniRecruitingNCT07311876Not applicable1 country
- Sub-Hertz Analysis of Viscoelasticity of Limbs in Patients With LymphedemaEnrolling by invitationNCT04258319Not applicable1 country
- Pectoral Nerve Block Versus Paravertebral Block In The Incidence of Chronic Pain After Breast Cancer SurgeryRecruitingNCT06082206Not applicable1 country
- Sahid Method for Secondary Unilateral Lower Limb LymphedemaEnrolling by invitationNCT07198698Not applicable1 country
- Assessment of the Efficacy of the Dynamic Decongestive System in the Intensive Phase of Lower Limb LymphedemaNot yet recruitingNCT07622615Not applicable2 countries
- Erector Spinae Block Versus Paravertebral Block on Chronic Pain After MastectomyRecruitingNCT07561411Not applicable1 country
- Assessment of the Efficacy of the Dynamic Decongestive System in the Maintenance Phase of Lower Limb LymphedemaNot yet recruitingNCT07603531Not applicable2 countries
- Lymphedema Surveillance StudyRecruitingNCT027438581 country
- Clinical Study to Evaluate the Effectiveness and Health Economics of a Novel Portable Non-Pneumatic Active Compression Device (NPCD) for Lymphedema/PhlebolymphedemaRecruitingNCT06418282Not applicable1 country
- ILR to Prevent BRCL_MCC 23608RecruitingNCT07127003Not applicable1 country
- Measuring Fluid Buildup in Cancer PatientsRecruitingNCT074436181 country
- CONNECT: A Multi-Cohort, Prospective Investigation of the Symani® Surgical SystemRecruitingNCT06866197Not applicable1 country
- Effects of Extracorporeal Shock Wave Therapy and Pulse Electromagnetic Field Therapy on LymphoedemaRecruitingNCT06041958Not applicable1 country