An observational study in Lymphedema, sponsored by Istituto Ortopedico Rizzoli. Recruiting at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-22.
Sponsored by Istituto Ortopedico Rizzoli · Observational
Lymphedema is a chronic condition characterized by the accumulation of lymphatic fluid in tissues, frequently resulting from oncological treatments, trauma, or cancer. This condition causes significant functional impairment and severely impacts patients' quality of life, requiring complex and multidisciplinary therapeutic approaches.
In recent years, reconstructive microsurgery has played an increasingly important role in lymphedema treatment due to high-precision technologies. The use of ultra-high magnification operating microscopes allows the visualization of sub-millimetric vascular structures, enabling lymphatic-venous anastomoses and lymph node transfers on extremely small vessels (0.3-0.5 mm). Additionally, advanced intraoperative imaging, such as indocyanine green fluorescence, allows real-time identification of lymphatic vessels and patency assessment, improving surgical accuracy and clinical outcomes.
While recent experience shows high procedural success rates, a retrospective and systematic analysis of clinical data is necessary to structuredly evaluate functional outcomes. Therefore, this retrospective study aims to analyze the clinical experience gained to define the role of advanced microsurgical technologies in optimizing the therapeutic pathway for patients with lymphedema
569 studies on the registry are indexed under Lymphedema; 136 are open to participants now.
This study's planned enrollment of 15 is below the median of 108 across 147 observational studies indexed under Lymphedema.
Browse Lymphedema studies →Istituto Ortopedico Rizzoli is the lead sponsor of 304 studies on the registry; 104 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult patients undergoing reconstructive microsurgery with lymphatic-venous anastomosis;
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Exclusion Criteria:
all adult patients with lymphedema treated in Istituto Ortopedico Rizzoli
Procedure: Surgery with and without the aid of Indocyanine Green (ICG)
Microsurgical treatment for Lymphedema
Change in limb volume
Lymphedema improvement evaluated through the reduction of the volume of the treated limb compared to the preoperative baseline value.
Time frame: Preoperative (baseline), 7 days, 1 month, 3 months, and 6 months postoperatively
Change in limb circumference
Lymphedema improvement evaluated through the reduction of the circumference of the treated limb compared to the preoperative baseline value.
Time frame: Preoperative (baseline), 7 days, 1 month, 3 months, and 6 months postoperatively
Plan to share: Undecided
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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