Post-Lyme Disease Syndrome clinical trials

The registry lists 22 studies for Post-Lyme Disease Syndrome across 2 countries. 9 are recruiting or about to start. 15 of them are mainly about Post-Lyme Disease Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-28.

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Status

Recruiting: 8
Completed: 7
Withdrawn: 3
Suspended: 2
Not yet recruiting: 1
Terminated: 1

Phase

Phase 2: 6
Phase 1: 5
Phase 3: 1
Early Phase 1: 1

Where

United States: 19
France: 1

Who runs them

Research Foundation for Mental Hygiene, Inc. (3) · Icahn School of Medicine at Mount Sinai (2) · Columbia University (2) · Optimal Health Research (2) · Spaulding Rehabilitation Hospital (2) · ProgenaBiome (2) · Johns Hopkins University (2) · Children's National Research Institute (2)

What is being tested here

Drugs under test in Post-Lyme Disease Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	All
Ceftriaxone	1	1
Tetracycline	0	1
Psilocybin	0	1
Disulfiram	0	1

Coming up

0phase 3 studies under way

7studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 7

Nov 2026taVNS for Persistent Symptoms From Lyme Disease · Columbia University
Dec 2026Pregnancy and Early Neurodevelopmental Outcomes Following In Utero Lyme Disease Exposure · Children's National Research Institute
Dec 2026Ceftriaxone Pulse Dose for Post-Treatment Lyme Disease · State University of New York - Upstate Medical University
Dec 2026Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome · Icahn School of Medicine at Mount Sinai
Dec 2026Navigating Pregnancy and Parenthood With Lyme Disease · Children's National Research Institute
Dec 2026Sana Device for Post-Treatment Lyme Disease Syndrome Chronic Pain · Icahn School of Medicine at Mount Sinai
Jun 2027Transcranial Direct Current Stimulation for Post Treatment Lyme Disease · Columbia University

Who these studies take

Of the 8 Post-Lyme Disease Syndrome studies recruiting now, 5 (63%) set no upper age limit and 3 (38%) stop at 75 or younger. 1 (13%) take children under 18. 1 (13%) are for women only and 0 (0%) for men only; 1 (13%) take healthy volunteers.

Recruiting studies that take each age, of 8
Age	Women	Men
10	1 (13%)	1 (13%)
18	8 (100%)	7 (88%)
30	8 (100%)	7 (88%)
40	8 (100%)	7 (88%)
50	8 (100%)	7 (88%)
65	8 (100%)	7 (88%)
75	6 (75%)	5 (63%)
85	5 (63%)	4 (50%)

Across all 22 studies, recruiting or not: 36% stop at 75 or younger and 14% at 65; 23% take children; 5% are for women only and 0% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

Studies

Recruiting first, then most recently updated. Showing 22 of 22. search them.