Leukoplakia, Oral clinical trials
The registry lists 48 studies for Leukoplakia, Oral across more than 10 countries. 11 are recruiting or about to start. 34 of them are mainly about Leukoplakia, Oral (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Who runs them
National Cancer Institute (NCI) (7) · Cairo University (3) · Alexandria University (2) · National Taiwan University Hospital (2) · King Khalid University (1) · Jacobus Pharmaceutical (1) · Fox Chase Cancer Center (1) · University College, London (1)
What is being tested here
Drugs under test in Leukoplakia, Oral studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5
- Nov 2026Evaluation of Artificial Intelligence in Diagnosis and Risk Assessment of Oral Potentially Malignant Disorders · Ain Shams University
- Dec 2026Salivary IL-8 and Serum IL-6 as Biomarkers for Oral Potentially Malignant Disorders in Smokers and Never-Smokers · British University In Egypt
- Apr 2027SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomography · University of Palermo
- Jul 2027Pioglitazone-Metformin Combination Treatment for High Risk Oral Preneoplasia · University of Minnesota
- Sep 2027Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia · Cairo University
Who these studies take
Of the 7 Leukoplakia, Oral studies recruiting now, 5 (71%) set no upper age limit and 0 (0%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (14%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 5 (71%) | 5 (71%) |
| 30 | 6 (86%) | 6 (86%) |
| 40 | 7 (100%) | 7 (100%) |
| 50 | 7 (100%) | 7 (100%) |
| 65 | 7 (100%) | 7 (100%) |
| 75 | 7 (100%) | 7 (100%) |
| 85 | 6 (86%) | 6 (86%) |
Across all 48 studies, recruiting or not: 15% stop at 75 or younger and 4% at 65; 13% take children; 0% are for women only and 0% for men only; 21% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 14, 2026.
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 48 of 48. search them.
- Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral LeukoplakiaRecruitingNCT07387900Phase 21 country
- Salivary IL-8 and Serum IL-6 as Biomarkers for Oral Potentially Malignant Disorders in Smokers and Never-SmokersRecruitingNCT079155701 country
- Pioglitazone-Metformin Combination Treatment for High Risk Oral PreneoplasiaRecruitingNCT05727761Phase 21 country
- Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral LesionsNot yet recruitingNCT06876038Phase 21 country
- Comparison of Topical Photodynamic Therapy With Topical Calcipotriol in Management of Oral LeukoplakiaNot yet recruitingNCT07453472Phase 31 country
- Efficacy of Topical Coenzyme Q10 and Curcumin for Oral Leukoplakia TreatmentRecruitingNCT07331935Not applicable1 country
- Evaluation of Artificial Intelligence in Diagnosis and Risk Assessment of Oral Potentially Malignant DisordersNot yet recruitingNCT07318922
- SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence TomographyRecruitingNCT063210031 country
- Oral Potentially Malignant Disorders: Comparison Between Surgical Treatment and Wait and See ApproachRecruitingNCT04858100Not applicable1 country
- Analyzing Handprint Patterns to Predict Oral Cancer Risks: A Comparative StudyNot yet recruitingNCT06256809
- Prediction of Malignant Transformation of Oral Leukoplakia Using a MAGE-A-based ImmunoscoreRecruitingNCT039753221 country
- FENDRR and CRNDE With DUSP1 and DMBT1 in Oral Leukoplakia and Oral Squamous Cell CarcinomaCompletedNCT079067951 country
- Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or ErythroplakiaActive, not recruitingNCT05237960Phase 22 countries
- Fenretinide Mucoadhesive Patch: Evaluation of Oral Cancer Prevention Efficacy in Adults With Premalignant Oral Lesions.CompletedNCT07149220Phase 11 country
- Identification of Oral Lesions Through an Autofluorescence SystemCompletedNCT05942794Not applicable1 country
- Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant LesionActive, not recruitingNCT02581137Phase 22 countries
- Topical Calcipotriol Versus Photodynamic Therapy in the Treatment of Oral LeukoplakiaActive, not recruitingNCT07658508Phase 2/31 country
- Unveiling the Protein Expression Patterns in Oral Lichen Planus and Leukoplakia Through Comparative Salivary ProteomicsCompletedNCT074163181 country
- Biomarkers for Oral CancerCompletedNCT003414971 country
- Safety and Efficacy of Nivolumab in Treating Oral Proliferative Verrucous LeukoplakiaCompletedNCT03692325Phase 21 country
- Saliva and Plasma Exosomes for Oral Leukoplakia Malignant Transformation Diagnosis and Oral Cancer Prognosis MonitoringCompletedNCT064698921 country
- Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant LesionsCompletedNCT057308551 country
- Intra and Extra Oral Inspection of Oral MucosaTerminatedNCT040794911 country
- Intralesional 5-fluorouracil Injection for the Treatment of Oral LeukoplakiaWithdrawnNCT05505539Phase 11 country
- Pioglitazone Hydrochloride in Preventing Head and Neck Cancer in Patients With Oral LeukoplakiaCompletedNCT00099021Phase 21 country
- This Study is to Evaluate the Safety and Pharmacokinetics of SBS-101 in Patients With Oral Premalignant LesionsWithdrawnNCT03939364Phase 11 country
- Clinical Evaluation of the OncAlert RAPID in Subjects Presenting for Evaluation and/or Initial Biopsy; Impact on Decision-MakingCompletedNCT032398341 country
- Diagnostic Accuracy of Salivary Gamma-synuclein in Oral Malignant and Premalignant LesionsStatus unknownNCT04732741
- Candida Associated Cytokines in Oral LeukoplakiaCompletedNCT047129291 country
- A Randomized Study of Sulindac in Oral Premalignant LesionsCompletedNCT00299195Not applicable2 countries
- Oral Cancer Screening and Education in Hong KongStatus unknownNCT04487938
- Diagnostic Accuracy of Salivary DNA Integrity Index in Oral Malignant and Premalignant LesionsCompletedNCT036825621 country
- Oral Epithelial Dysplasia Informational Needs QuestionnaireCompletedNCT041532661 country
- Malondialdehyde and Nitrous Oxide as Salivary Biomarkers for Different Oral LesionsCompletedNCT042674191 country
- Evaluation of Effect of Topical Melatonin in Treatment of Oral LeukoplakiaStatus unknownNCT04251845Not applicable1 country
- Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection EfficacyCompletedNCT03031899
- Photodynamic Therapy With Porfimer Sodium in Treating Patients With Precancerous Lesions, Cancer, or Other Disease of the Aerodigestive TractCompletedNCT00453336Phase 21 country
- Pioglitazone for Oral Premalignant LesionsTerminatedNCT00951379Phase 23 countries
- Bowman-Birk Inhibitor Concentrate in Preventing Cancer in Patients With Oral LeukoplakiaCompletedNCT00330382Phase 21 country
- Photodynamic Therapy Using Aminolevulinic Acid in Treating Patients With Oral LeukoplakiaTerminatedNCT00571558Phase 11 country
- Aspirin Mouthwash in Treating Patients With Oral LeukoplakiaCompletedNCT01238185Phase 11 country
- Celecoxib in Preventing Head and Neck Cancer in Patients With Oral LeukoplakiaCompletedNCT00101335Phase 21 country
- Rosiglitazone Maleate in Treating Patients With Oral LeukoplakiaCompletedNCT00369174Phase 21 country
- Photodynamic Therapy for Oral Leukoplakia and ErythroleukoplakiaCompletedNCT00155337Phase 41 country
- Least Invasive Nonlinear Light MicroscopyStatus unknownNCT007674421 country
- A Phase II Trial to Assess the Effects of Green Tea in Oral LeukoplakiaTerminatedNCT00176566Phase 21 country
- Treatment and Suppression of Hairy Leukoplakia in ARC Patients With Oral Acyclovir (ACV)CompletedNCT00002026Not applicable1 country
- Dapsone 100 Mg Versus 50 as Primary Prophylaxis for Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS-Related Complex (ARC)CompletedNCT00002043Not applicable1 country