Mouth Neoplasms clinical trials
The registry lists 447 studies for Mouth Neoplasms across more than 10 countries. 131 are recruiting or about to start. 205 of them are mainly about Mouth Neoplasms (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 5 narrower conditions too, such as Salivary Gland Neoplasms: 782 studies, 177 open.
Get an email when these change. Save the Mouth Neoplasms studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Status
Who runs them
M.D. Anderson Cancer Center (25) · National Cancer Institute (NCI) (24) · National Taiwan University Hospital (23) · Cairo University (12) · Tata Memorial Hospital (8) · Shanghai Jiao Tong University School of Medicine (7) · Roswell Park Cancer Institute (7) · Chang Gung Memorial Hospital (7)
What is being tested here
Drugs under test in Mouth Neoplasms studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Paclitaxel | 3 | 0 | 11 |
| Cetuximab | 3 | 2 | 10 |
| Carboplatin | 3 | 2 | 7 |
| Cisplatin | 2 | 2 | 13 |
| Pembrolizumab | 2 | 0 | 7 |
| Nivolumab | 2 | 0 | 4 |
| Cemiplimab | 2 | 0 | 3 |
| Celecoxib | 1 | 1 | 7 |
| Ipatasertib | 1 | 0 | 2 |
| Proflavine | 1 | 0 | 2 |
Drug classes tested here Immune checkpoint inhibitors 11 open · Antimitotic agents 3 open · Antimetabolites 2 open · NSAIDs 2 open · Tyrosine kinase inhibitors (TKIs) 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Oct 2027Upfront Surgery Vs Induction Chemotherapy Followed By Surgery In Oral Cancers: · Phase 3 · All India Institute of Medical Sciences, Jodhpur
- Nov 2026Microbiome in Head and Neck Squamous Cell Carcinoma · University of Colorado, Denver
- Nov 2026Effects of a Perma-h Model Mobile-based Rehabilitation Support Program on Hope, Self-efficacy, Perceived Social Support and Rehabilitation Outcomes in Post- Tracheostomy Oral Cancer Patients · Hainan Medical College
- Dec 2026Safety and Efficacy of APG-157 in Head and Neck Cancer · Aveta Biomics, Inc.
- Dec 2026Artificial Intelligence for the Diagnosis of Oral Lesions · Assistance Publique - Hôpitaux de Paris
- Dec 2026Tissue Adhesive Versus Sutures in Oral Biopsy Closure · Damascus University
- Dec 2026Gross Examinations Versus Frozen Section for Assessment of Surgical Margins in Oral Cancers · Dr.Pankaj Chaturvedi
- Dec 2026Detection of Oral and Throat Cancers Using OralViome Cancer Testing System · Viome
- Dec 2026Validity of Viome's Oral/throat Cancer Test · Viome
- Dec 2026Extended Follow Up of Young Women in Costa Rica Who Received Vaccine for Human Papillomavirus Types 16 and 18 and Unvaccinated Controls · National Cancer Institute (NCI)
Who these studies take
Of the 97 Mouth Neoplasms studies recruiting now, 58 (60%) set no upper age limit and 23 (24%) stop at 75 or younger. 5 (5%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 14 (14%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (4%) | 4 (4%) |
| 18 | 83 (86%) | 83 (86%) |
| 30 | 96 (99%) | 96 (99%) |
| 40 | 96 (99%) | 96 (99%) |
| 50 | 95 (98%) | 95 (98%) |
| 65 | 96 (99%) | 96 (99%) |
| 75 | 84 (87%) | 84 (87%) |
| 85 | 69 (71%) | 69 (71%) |
Across all 447 studies, recruiting or not: 19% stop at 75 or younger and 7% at 65; 9% take children; 1% are for women only and 1% for men only; 19% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Mouth Neoplasms studies take
Of 44 phase 2 interventional studies under Mouth Neoplasms, half reached primary completion within 56 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 56 mo42–97 · 44 studies | — | — |
| Interventional, no phase | 30 mo17–107 · 99 studies | — | 27 mo16–97 · 98 studies |
| Observational | 47 mo23–216 · 48 studies | — | 47 mo23–216 · 44 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting2
- Effectiveness of Hydrogen Water Intervention on Acute Oral Inflammation, Oral Microbiota, and Pain Following Free Flap Reconstruction in Patients With Oral CancerOct 27, 2026NCT07306546
- Window Trial of Intratumoral (IT) Neoadjuvant Fluorescently Labelled Nivolumab (nivo800) in Head and Neck Squamous Cell Carcinoma (HNSCC)Oct 19, 2026NCT07741565
Results posted1
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 50 of 447. Browse all 447 → or search them.
- Window Trial of Intratumoral (IT) Neoadjuvant Fluorescently Labelled Nivolumab (nivo800) in Head and Neck Squamous Cell Carcinoma (HNSCC)RecruitingNCT07741565Early Phase 11 country
- BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot StudyRecruitingNCT05136196Phase 21 country
- Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous TreatmentRecruitingNCT06589804Phase 31 country
- LIMA1 Immunohistochemistry and Depth of Invasion as Prognostic Biomarkers in Oral Squamous Cell CarcinomaEnrolling by invitationNCT079343161 country
- Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral CancerRecruitingNCT06627270Phase 21 country
- Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base TumorsRecruitingNCT04265430Phase 41 country
- Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck CancerRecruitingNCT05172245Phase 12 countries
- Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)RecruitingNCT04198766Phase 1/24 countries
- Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal VolunteersRecruitingNCT009004191 country
- Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC)Not yet recruitingNCT07552558Phase 1/21 country
- Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell CarcinomaRecruitingNCT07156227Phase 11 country
- Flap Sparing in Postoperative Radiotherapy of Oral Cavity CancersRecruitingNCT06798922Phase 31 country
- Effectiveness of Hydrogen Water Intervention on Acute Oral Inflammation, Oral Microbiota, and Pain Following Free Flap Reconstruction in Patients With Oral CancerRecruitingNCT07306546Not applicable1 country
- TMV Vaccine Alone or With Toripalimab-tpzi for Recurrent Head and Neck Squamous Cell CarcinomaRecruitingNCT07898124Phase 11 country
- Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck CancerRecruitingNCT07195734Phase 21 country
- Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck CancerRecruitingNCT06980038Phase 21 country
- Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)RecruitingNCT07460765Phase 11 country
- Rehabilitation Through Individualized Support and ExerciseNot yet recruitingNCT07857096Not applicable1 country
- Intraoperative Methadone for the Management of Postoperative Pain in Patients With Head and Neck CancersRecruitingNCT07857655Phase 41 country
- Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States PopulationRecruitingNCT06997068Phase 21 country
- Oral Cancer Awareness in EgyptNot yet recruitingNCT05604105
- DESTINY-PANTUMOUR04RecruitingNCT071240001 country
- Feasibility and Validation of an Automated AI-Enabled Deep Ultraviolet (DUV) Cytology Platform for Point-of-Care Oral Cancer TriageNot yet recruitingNCT07842211Not applicable1 country
- Risk Factors of Jaw Osteoradionecrosis in Oral Cavity Cancer Patients Post-RadiotherapyNot yet recruitingNCT07836829
- Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck CancerRecruitingNCT06736379Phase 11 country
- Neck Observation or Elective Neck Dissection in cT1N0M0 OSCCRecruitingNCT06623266Not applicable1 country
- Neoadjuvant Sintilimab Plus Chemotherapy for cT2N0M0 Oral Squamous Cell CarcinomaNot yet recruitingNCT07827872Phase 31 country
- Study to Identify Biomarkers of Oral Cavity Cancer Response to Neoadjuvant Immunotherapy Prior to Definitive SurgeryRecruitingNCT07343596Not applicable1 country
- Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone SurgeryRecruitingNCT02734537Phase 21 country
- Mandibular Reconstruction Preplanning (ViPMR)RecruitingNCT05429099Not applicable1 country
- Thermotherapy for Head and Neck Cancer PatientsRecruitingNCT07690618Phase 11 country
- Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and Patients With CancerNot yet recruitingNCT07781852Early Phase 11 country
- Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck CancerRecruitingNCT06532279Phase 21 country
- Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity CancerRecruitingNCT04333537Phase 2/32 countries
- Tongue Proactive Strengthening Exercise Program Following Partial/Hemi Glossectomy and ReconstructionRecruitingNCT07110142Not applicable1 country
- Study Comparing Different Neck Treatment Approaches in Patients With Oral Cancer Without Visible Neck SpreadRecruitingNCT07726199Not applicable1 country
- Study Comparing Limited and Extensive Neck Surgery in Oral Cancer Patients With Neck SpreadRecruitingNCT07717307Not applicable1 country
- Window Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck CancerRecruitingNCT06819228Phase 11 country
- Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT TrialRecruitingNCT07121595Phase 21 country
- Cemiplimab and Cetuximab Prior Salvage Surgery in Patients With Recurrent Oral Cavity and HPV-negative Oropharyngeal Squamous Cell CarcinomaRecruitingNCT06448026Phase 21 country
- Wide-Field and High Resolution In Vivo Imaging in Visualizing Lesions in Patients With Oral Neoplasia Undergoing SurgeryRecruitingNCT01269190Not applicable1 country
- Role of Acetaldehyde in the Development of Oral CancerRecruitingNCT05973656Not applicable1 country
- Morphological Changes of Upper Trapezius Muscle After Physotherapy in Oral CancerRecruitingNCT071665751 country
- Effects of a Perma-h Model Mobile-based Rehabilitation Support Program on Hope, Self-efficacy, Perceived Social Support and Rehabilitation Outcomes in Post- Tracheostomy Oral Cancer PatientsNot yet recruitingNCT07714967Not applicable2 countries
- A Feasibility Study of AI-Assisted Physiotherapy for Oral Cancer PatientsNot yet recruitingNCT07635381Not applicable1 country
- Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or RadiationRecruitingNCT06662058Not applicable1 country
- Disease Evolution and Risk Factors of AIDS-related Prevalent CancersNot yet recruitingNCT07696169
- The Importance of Mucosal Screening in the Prevention of Oral Cancer.Enrolling by invitationNCT07682883Not applicable1 country
- APG-157 in Locally Advanced Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT07667296Phase 3
- Integrated Cancer Repository for Cancer ResearchRecruitingNCT020126991 country