Lactose Intolerance clinical trials
The registry lists 53 studies for Lactose Intolerance across more than 10 countries. 6 are recruiting or about to start. 50 of them are mainly about Lactose Intolerance (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-20.
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Who runs them
Purdue University (4) · Ritter Pharmaceuticals, Inc. (4) · University Hospitals, Leicester (3) · Eurofarma Laboratorios S.A. (2) · a2 Milk Company Ltd. (2) · University of Turku (1) · University of Erlangen-Nürnberg Medical School (1) · Rabin Medical Center (1)
What is being tested here
Drugs under test in Lactose Intolerance studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 2
- Jan 2027Screening of Lactose Intolerance Among IBS Patients Diarrhea Dominant · Assiut University
- Feb 2027Goat vs. Cow Milk Digestive Tolerance · Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Who these studies take
Of the 4 Lactose Intolerance studies recruiting now, 1 (25%) set no upper age limit and 3 (75%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (50%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 4 (100%) | 4 (100%) |
| 30 | 4 (100%) | 4 (100%) |
| 40 | 4 (100%) | 4 (100%) |
| 50 | 4 (100%) | 4 (100%) |
| 65 | 4 (100%) | 4 (100%) |
| 75 | 1 (25%) | 1 (25%) |
| 85 | 1 (25%) | 1 (25%) |
Across all 53 studies, recruiting or not: 79% stop at 75 or younger and 60% at 65; 13% take children; 0% are for women only and 2% for men only; 47% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Lactose Intolerance studies take
Of 22 interventional studies with no phase under Lactose Intolerance, half reached primary completion within 9 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 9 mo5–14 · 22 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
- Milk Beta Caseins on Digestive Discomfort, Gastric EmptyingOct 20, 2026NCT07884123
Studies
Recruiting first, then most recently updated. Showing 50 of 53. Browse all 53 → or search them.
- Milk for Diabetes PreventionRecruitingNCT06513026Not applicable1 country
- Screening of Lactose Intolerance Among IBS Patients Diarrhea DominantNot yet recruitingNCT06931379
- Goat vs. Cow Milk Digestive ToleranceRecruitingNCT07239856Not applicable1 country
- Proper Dietary Management, Follow-up, and Lactase Enzyme Supplementation for Lactose IntoleranceRecruitingNCT067736501 country
- Comparing the Inflammation, Maldigestion and Symptoms Due to Commercial Milk and A2 MilkRecruitingNCT05660278Not applicable1 country
- The Role of Irritable Bowel Syndrome in Lactose Intolerance (LION)Not yet recruitingNCT05100719Not applicable1 country
- Comparing the Adaptation of Commercial Milk and A2 Milk in Lactose MaldigestersCompletedNCT05669274Not applicable1 country
- Milk Beta Caseins on Digestive Discomfort, Gastric EmptyingCompletedNCT07884123Not applicable1 country
- A Bifido Bacteria to Improve Lactose Digestion and ToleranceCompletedNCT05668468Not applicable1 country
- Effect of a Probiotic Formulation in Adults With Lactose Intolerance and Methanogenic Intestinal OvergrowthCompletedNCT07652827Not applicable1 country
- Lactobreath: A Study to Diagnose Lactose Intolerance Using Breath MarkersCompletedNCT06177938Not applicable1 country
- Low-grade Inflammation and Gut Symptoms From A2 and Hydrolyzed A1 MilkCompletedNCT05305391Not applicable1 country
- Lactase Enzyme Supplementation for Growth and Feeding Tolerance in Preterm InfantsCompletedNCT07494123Not applicable1 country
- Trial of Rice-Based F-75 in Severe Malnutrition & Persistent Diarrhea in Children (SAM-RICE Study)CompletedNCT07070856Not applicable1 country
- MSOT for Assessment of Intestinal Transit Time in Lactose Intolerance PatientsCompletedNCT06617364Not applicable1 country
- Comparison of the Effectiveness of Oral Lactase Enzyme and Lactose Free FormulaCompletedNCT06827405Not applicable1 country
- Lactose Intolerance in Infants With Gastrointestinal DisturbancesCompletedNCT06789068Not applicable1 country
- Effect of a Combination of Lactase and L. Salivarius DSM 34078 in Individuals With Lactose IntoleranceCompletedNCT06107088Not applicable1 country
- Does Daily Supplementation of Lactobacillus Acidophilus MPH734, for One Week, Affect Acute (Immediate), Subacute (7 Days), and Post-treatment Discontinuation Lactose Metabolism, Gastrointestinal Symptoms, and Clinical Markers of Inflammation and Safety Compared to a PlaceboCompletedNCT04531033Not applicable1 country
- Association Between Lactase Deficiency, and the Small Intestinal Microbiome in Adults.CompletedNCT038600511 country
- Effects of Raw Versus Other Milk Sources on Lactose DigestionCompletedNCT01129791Not applicable1 country
- Effect of a Probiotic With High Beta-galactosidase Activity on Patients With Lactose IntoleranceCompletedNCT05367453Not applicable1 country
- Evaluation of GIMate Handheld Hydrogen Breath Monitor for Diagnosis of Lactose MalabsorptionCompletedNCT04754724Not applicable1 country
- Fructose and Lactose Intolerance and Malabsorption in Functional Gastrointestinal DisordersStatus unknownNCT020858891 country
- Lactose Intolerance and Cow's Milk Protein Allergy in Non-celiac Wheat Sensitivity PatientsCompletedNCT030082521 country
- Effects of A2 Milk on Gastrointestinal Function in Non-lactose Milk IntoleranceCompletedNCT03060395Not applicable1 country
- HYBRID: Hydrogen Breath Test in Lactose DigestionCompletedNCT02703987Not applicable1 country
- Clinical Utility of Breath Tests in GICompletedNCT032618561 country
- Effect of I31 Probiotic on Lactose IntoleranceCompletedNCT04164394Not applicable1 country
- Perceived Lactose IntoleranceCompletedNCT013312651 country
- Effect of Probiotic Supplementation on Lactose Maldigestion Induced by Lactose SolutionCompletedNCT03814668Not applicable1 country
- Evaluation of the Efficacy, Durability, Safety, and Tolerability of RP-G28 in Patients With Lactose IntoleranceCompletedNCT03597516Phase 31 country
- Effect of B.Bifidum 900791 Intake in Adult With Hypolactasia and Lactose IntoleranceStatus unknownNCT03952988Not applicable
- Validation of a Home-screening Test for Lactose IntoleranceWithdrawnNCT00844766
- Modulation of Lactase Expression by a New PPARgamma Ligand in Duodenal BiopsiesCompletedNCT02902016Not applicable1 country
- Effect of a Standard Meal on the Pharmacokinetic Profile of RP-G28 in Healthy Adult Male and Female SubjectsCompletedNCT03563846Phase 11 country
- Efficacy, Safety, and Tolerability Study of RP-G28 in Subjects With Lactose IntoleranceCompletedNCT02673749Phase 2/31 country
- Evaluation of LacTEST for the Diagnosis of Hypolactasia in Adults and Elderly Patients Presenting With Clinical Symptoms of Lactose IntoleranceCompletedNCT02636413Phase 41 country
- β-galactosidase Producing Probiotic Strains to Improve Lactose DigestionCompletedNCT02518295Not applicable1 country
- Incidence of Lactose Intolerance Among Self-reported Lactose Intolerant PeopleCompletedNCT02878876Phase 4
- Whole Milk Intake and Cardio-metabolic Risk FactorsStatus unknownNCT02798718Not applicable1 country
- The Effect of Probiotics on Lactose IntoleranceCompletedNCT01593800Not applicable
- Comparison of the Colonic Metabolism in Patients With Lactose Intolerance and Healthy ControlsCompletedNCT021714031 country
- Effects Comparison of A1 and A2 Milk on Gastrointestinal Physiology, Symptoms and Cognitive BehaviorCompletedNCT02406469Phase 4
- The Effects of Lactose Intolerance on Gastrointestinal Function and Symptoms in a Chinese PopulationStatus unknownNCT01286597Not applicable1 country
- A Non-inferiority, Multicenter and Randomized, Multiple-Dose Study About a Treatment to HypolactasiaCompletedNCT01145586Phase 31 country
- A Non-inferiority, Multicenter and Randomized, Single-Dose Study About a Treatment to Hypolactasia (LAILAI)CompletedNCT01145339Phase 31 country
- Acid Lactase in Combination With Yoghurt Bacteria for Improvement of Lactose Digestion in Lactose MalabsorbersCompletedNCT01593631Not applicable1 country
- Effectiveness, Safety and Tolerability Study of RP-G28 for Symptoms Associated With Lactose IntoleranceCompletedNCT01113619Phase 21 country
- Effects of Lactose on Fecal MicrofloraCompletedNCT00599859Not applicable1 country