Intraoperative Awareness clinical trials
The registry lists 55 studies for Intraoperative Awareness across more than 10 countries. 8 are recruiting or about to start. 46 of them are mainly about Intraoperative Awareness (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-22.
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Breast cancer · Recruiting: 2 came in, 3 changed
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A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
Washington University School of Medicine (3) · Ain Shams University (3) · Trakya University (2) · Başakşehir Çam & Sakura City Hospital (2) · Rajiv Gandhi Cancer Institute & Research Center, India (2) · Assiut University (2) · Medtronic - MITG (1) · Ömer Faruk Boran (1)
What is being tested here
Drugs under test in Intraoperative Awareness studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Sevoflurane | 0 | 0 | 3 |
| Dexmedetomidine | 0 | 0 | 2 |
| Propofol | 0 | 0 | 2 |
| Remifentanil | 0 | 0 | 1 |
| Isoproterenol | 0 | 0 | 1 |
| Ketamine | 0 | 0 | 1 |
| Esmolol | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Feb 2027Fear and Anxiety in Anesthesia-Naïve Patients Pre-operatively vs Post-operatively · Stony Brook University
- Mar 2027Evaluation of Intraoperative Awareness and Its Correlation With Processed EEG Biomarkers During Laparoscopic Surgery · Duzce University
- Jul 2027Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial · Washington University School of Medicine
Who these studies take
Of the 4 Intraoperative Awareness studies recruiting now, 4 (100%) set no upper age limit and 0 (0%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 4 (100%) | 4 (100%) |
| 30 | 4 (100%) | 4 (100%) |
| 40 | 4 (100%) | 4 (100%) |
| 50 | 4 (100%) | 4 (100%) |
| 65 | 4 (100%) | 4 (100%) |
| 75 | 4 (100%) | 4 (100%) |
| 85 | 4 (100%) | 4 (100%) |
Across all 55 studies, recruiting or not: 49% stop at 75 or younger and 44% at 65; 27% take children; 9% are for women only and 0% for men only; 31% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Intraoperative Awareness studies take
Of 18 interventional studies with no phase under Intraoperative Awareness, half reached primary completion within 19 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 19 mo13–33 · 18 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 55. Browse all 55 → or search them.
- Evaluation of Consciousness Depth (qCON) and Analgesia Depth (qNOX) Indices in General AnesthesiaNot yet recruitingNCT07887919
- Evaluation of Intraoperative Awareness and Its Correlation With Processed EEG Biomarkers During Laparoscopic SurgeryRecruitingNCT078315901 country
- Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia TrialRecruitingNCT05991453Not applicable1 country
- Fear and Anxiety in Anesthesia-Naïve Patients Pre-operatively vs Post-operativelyRecruitingNCT075594611 country
- Deep Learning Framework for Continuous Depth of Anesthesia ForecastingNot yet recruitingNCT075362301 country
- Anesthesia Awareness on YouTube: Content and Quality AnalysisNot yet recruitingNCT07323537
- The Effect of Wavelet Index in Monitoring the Sedation Depth of Remimazolam BesylateNot yet recruitingNCT06427785
- Manual Versus Targer-controll Infusion in Reduction of Awareness and DreamingRecruitingNCT03476213Not applicable1 country
- Evaluation of Influencing Variables in Awakening Concentration and Concentration at Body Movements of Propofol TCI (Targeted Controlled Infusion) Targeted at the Effector SiteCompletedNCT041291121 country
- Neuro-Mimic Indicators of Anesthesia Depth During General AnesthesiaCompletedNCT071990491 country
- Incidence of Intraoperative Awareness in Indian Patient PopulationSuspendedNCT03571945Not applicable1 country
- Comparison of Combined Dexmedetomidine and Ketamine (Ketodex) Versus Dexmedetomidine Alone in Awake Mapping for Deep Brain Stimulation: A Randomized Controlled TrialActive, not recruitingNCT07513935Phase 41 country
- Subconscious Effects of Intraoperative Speech: Health Professionals' PerceptionsCompletedNCT073967271 country
- Study to Determine if Patients Exposed to General Anesthesia Significant Numbers of Times Would Increase the Risk for Intraoperative Awareness.Active, not recruitingNCT058576181 country
- Knowledge and Awareness of Instruments Sterilization Protocols Among Healthcare Workers in Operation TheaterActive, not recruitingNCT070545801 country
- Assessment of Sedation Depth Using Processed EEG in ICU Patients With ARDS Receiving Neuromuscular Blockade: A Prospective Observational Study"CompletedNCT063378771 country
- Psychological Effect of Explicit Recall After Sedation (PEERS)CompletedNCT047473791 country
- The Effect of Anesthesia Depth Monitoring on Emergence Delirium in PediatricsCompletedNCT06323616Not applicable1 country
- Examination of The Relationshıp Between Body Mass Index And The Skin-Epidural Space DistanceCompletedNCT06316622Not applicable1 country
- THRIVE Feasibility TrialCompletedNCT05346588Phase 31 country
- The Depth of Paediatric Anaesthesia: Observational TrialStatus unknownNCT051937471 country
- A Study of Human Multi-Sensory IntegrationSuspendedNCT03498391Phase 21 country
- Anesthesia Depth Increases Delirium IncidenceCompletedNCT05656703Not applicable1 country
- Systematic Assessment and Targeted Improvement of Services Following Yearlong Surgical Outcomes SurveysCompletedNCT020320301 country
- Comparative Study of Bispectral Index (BIS) Values Obtained From Standard Frontal Position and Alternative Infra-orbital Position During Total Intravenous Anaesthesia (TIVA).CompletedNCT05441644Not applicable1 country
- Effect of Chan-Chuang Qigong With Breathing Meditation on Quality of Life in Patients With Breast CancerCompletedNCT05385146Not applicable1 country
- Validation of the French Version of the TEX-Q Questionnaire.Status unknownNCT05254704
- Enhanced Perioperative Care for the Prevention of Colorectal Anastomotic LeakageStatus unknownNCT05250882Not applicable2 countries
- Anesthesia Awareness in Pediatric Gastrointestinal Endoscopy NursesCompletedNCT050324431 country
- Awareness in Old Aged Patients During Laryngoscopy and Intubation Using Isolated Forearm TechniqueCompletedNCT05019560Phase 41 country
- ConsCIOUS2 Study of the Isolated Forearm Technique CommandsCompletedNCT03503357Not applicable7 countries
- Pediatric Validation of CONOX Monitor During SurgeryStatus unknownNCT048261461 country
- The Effect of Minimal Flow Sevoflurane AnesthesiaCompletedNCT04813952Not applicable1 country
- Awake Craniotomy for Arteriovenous MalformationCompletedNCT049498151 country
- Heart Rate Variability to Quantify General Anesthesia DepthStatus unknownNCT047887321 country
- İntraoperative Awareness Under General AnesthesiaStatus unknownNCT046977321 country
- Validity of Perfusion Index to Evaluate the Level of General Anaesthesia in Children.CompletedNCT034122141 country
- Adaptation of Perioperative Satisfaction Scale in Regional Anesthesia and Investigation of Its Psychometric PropertiesStatus unknownNCT04009018Not applicable1 country
- TIVA vs Inhalational Mode of AnaesthesiaCompletedNCT03807297Phase 21 country
- Standard Vs Supralabial Bispectral Index ScoresStatus unknownNCT042529111 country
- Role of Intraoperative Beta Blocker for Morbid Obese Patients Undergoing Laparoscopic Bariatric SurgeryStatus unknownNCT04086940Phase 41 country
- Decision Support System for AnesthetistsStatus unknownNCT040790361 country
- Direct REporting of Awareness in MaternitY PatientsStatus unknownNCT031003961 country
- Entropy and Surgical Pleth Index Guided Closed Loop Target Controlled Infusion Total Intravenous Anesthesia With PropofolStatus unknownNCT03773588Not applicable1 country
- Glasgow Coma Scales and General AnesthesiaCompletedNCT03521414Not applicable
- Effect of Remifentanil on the Bispectral Index in Women Undergoing Caesarean Delivery Under General AnaesthesiaCompletedNCT03508102Not applicable
- Comparison of Low Versus Normal Flow Anesthesia on Cerebral Oxygenation and Bispectral Index in Morbidly Obese PatientsCompletedNCT03438734Not applicable1 country
- The Impact of Maternal Sound on Awareness for Pediatric Patients Undergoing Cardiac SurgeryCompletedNCT02583295Not applicable1 country
- Epileptiform EEG Patterns During Induction of General Anaesthesia With Sevoflurane Compared to Those With PropofolCompletedNCT03209323Not applicable1 country
- Preoperative Anxiety at Oocyte RetrievalCompletedNCT03134651Not applicable