An observational study in Hypogonadism and Malignant Testicular Germ Cell Tumor, sponsored by University of Southern California. Suspended at 2 sites in United States. Open to male participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-05.
Sponsored by University of Southern California · Observational
This study evaluates 7 Tesla (T) magnetic resonance imaging (MRI) in observing changes in the brain (neuroimaging) in testicular cancer patients who have decreased testosterone (hypogonadism) and are on testosterone (androgen) replacement therapy. Symptoms of hypogonadism can include fatigue, weakness, loss of libido, depression, poor concentration and erectile dysfunction. Some patients experience mental changes after diagnosis and treatment. There is some evidence that hypogonadism produces structural changes in the brain. The 7T MRI uses radio waves and a very powerful magnet linked to a computer to create detailed pictures of areas inside the body. This study may help researchers learn if 7T MRI can produce better images to assess the changes in the brain structure of testicular patients with hypogonadism and on androgen replacement therapy (ART).
PRIMARY OBJECTIVE:
I. To assess longitudinal structural changes in brain architecture using MRI in hypogonadal men with testis cancer being treated with androgen replacement therapy.
OUTLINE: This is an observational study.
Patients undergo 7T MRI over 1-2 hours at baseline and at 12 months after baseline. Patients also undergo a proctored cognitive assessment over approximately 1 hour prior to each MRI. Additionally, patients undergo blood sample collection at screening and at 12 months after baseline MRI.
345 studies on the registry are indexed under Hypogonadism; 43 are open to participants now.
This study's planned enrollment of 10 is below the median of 96 across 66 observational studies indexed under Hypogonadism.
Browse Hypogonadism studies →University of Southern California is the lead sponsor of 773 studies on the registry; 135 are open to participants now.
Of its 68 completed or terminated interventional studies of FDA-regulated products, 32 (47%) have results posted.
Counted across the registry records on this site, refreshed daily.
Male testicular patients with hypogonadism on androgen replacement therapy recruited from University of Southern California/Kenneth Norris, Jr Comprehensive Cancer Center and Hospital.
Exclusion Criteria:
Standard contraindications for MRI:
Patients undergo 7T MRI over 1-2 hours at baseline and at 12 months after baseline. Patients also undergo a proctored cognitive assessment over approximately 1 hour prior to each MRI. Additionally, patients undergo blood sample collection at screening and at 12 months after baseline MRI.
Procedure: 7 Tesla Magnetic Resonance Imaging · Procedure: Biospecimen Collection · Procedure: Cognitive Assessment
Undergo 7T MRI
Also known as: 7 T MRI, 7 Tesla MRI
Undergo blood sample collection
Also known as: Biological Sample Collection, Biospecimen Collected, Specimen Collection
Undergo cognitive assessment
Brain structural connectivity
Measured using T1-weighted and diffusion tensor magnetic resonance imaging (MRI).
Time frame: At baseline and 12 months
Brain functional connectivity
Measured using resting-state functional MRI.
Time frame: At baseline and 12 months
Brain metabolic profiles
Evaluated by MR spectroscopy.
Time frame: At baseline and 12 months
Brain perfusion
Evaluated by arterial spin labeling MRI.
Time frame: At baseline and 12 months
This study is suspended, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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University of Southern California