Familial Mediterranean Fever clinical trials
The registry lists 61 studies for Familial Mediterranean Fever across more than 10 countries. 27 are recruiting or about to start. 53 of them are mainly about Familial Mediterranean Fever (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
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Who runs them
Istanbul University - Cerrahpasa (7) · Sheba Medical Center (5) · Cairo University (5) · Novartis Pharmaceuticals (4) · Assistance Publique - Hôpitaux de Paris (3) · Istanbul University (3) · Assiut University (2) · Hospices Civils de Lyon (2)
What is being tested here
Drugs under test in Familial Mediterranean Fever studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9, phase 3 first
- Dec 2026Randomized Controlled Trial in Patients on Long-term Colchicine With Colchicine-resistant Familial Mediterranean Fever (FMF) to Evaluate the Efficacy of On-demand Anakinra Treatment for Painful Attacks in Patients Who Refuse Continuous Daily Therapy · Phase 3 · Assistance Publique - Hôpitaux de Paris
- Dec 2026A Study on the Use of Canakinumab Among Familial Mediterranean Fever and Still's Disease Patients · Novartis Pharmaceuticals
- Dec 2026Metabolic Syndrome Resposne to Dietary Limitations in Familial Mediterranean Fever in Adolescents · Cairo University
- Dec 2026Observing the Efficacy and Safety of Different Drugs Used in Real-world Familial Mediterranean Fever (FMF) Cases · Tongji Hospital
- Jan 2027Skin Autofluorescence Assessment of Advanced Glycation End Products in Rheumatic Diseases · Bursa City Hospital
- Mar 2027Health-related Quality of Life, Electrocardiographic and Holter Findings in Children With Familial Mediterranean Fever · Sohag University
- Mar 2027Investigation of the Validity, Reliability and Responsiveness of the BETY-BQ in FMF · Aysima Barlak
- Sep 2027Genotype and Phenotype in Pediatric Familial Mediterranean Fever · Assiut University
- Oct 2027Physical Abilities of Teenagers With Familial Mediterranean Fever · Véronique Hentgen
Who these studies take
Of the 12 Familial Mediterranean Fever studies recruiting now, 4 (33%) set no upper age limit and 5 (42%) stop at 75 or younger. 10 (83%) take children under 18. 2 (17%) are for women only and 0 (0%) for men only; 3 (25%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 7 (58%) | 7 (58%) |
| 18 | 8 (67%) | 8 (67%) |
| 30 | 8 (67%) | 7 (58%) |
| 40 | 8 (67%) | 7 (58%) |
| 50 | 8 (67%) | 7 (58%) |
| 65 | 7 (58%) | 7 (58%) |
| 75 | 7 (58%) | 7 (58%) |
| 85 | 5 (42%) | 5 (42%) |
Across all 61 studies, recruiting or not: 69% stop at 75 or younger and 61% at 65; 62% take children; 3% are for women only and 2% for men only; 26% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 15, 2026.
Studies
Recruiting first, then most recently updated. Showing 50 of 61. Browse all 61 → or search them.
- Familial Mediterranean Fever and Related Disorders: Genetics and Disease CharacteristicsRecruitingNCT000013731 country
- Goflikicept for Resolution and Prevention of Attacks in Pediatric and Adolescent Patients With Colchicine-Resistant or Colchicine-Intolerant Familial Mediterranean FeverNot yet recruitingNCT07880886Phase 31 country
- Genotype and Phenotype in Pediatric Familial Mediterranean FeverNot yet recruitingNCT07849998
- Metabolic Syndrome Resposne to Dietary Limitations in Familial Mediterranean Fever in AdolescentsRecruitingNCT07833007Not applicable1 country
- A Study on the Use of Canakinumab Among Familial Mediterranean Fever and Still's Disease PatientsRecruitingNCT075172501 country
- Validity and Reliability of the International Physical Fitness Questionnaire and the Self-Perceived Health-Related Physical Fitness Questionnaire in Children and Adolescents With JIA and FMFNot yet recruitingNCT07617558
- AGE and CALLY Index in Familial Mediterranean FeverNot yet recruitingNCT07439341
- Observing the Efficacy and Safety of Different Drugs Used in Real-world Familial Mediterranean Fever (FMF) CasesRecruitingNCT070774731 country
- Skin Autofluorescence Assessment of Advanced Glycation End Products in Rheumatic DiseasesNot yet recruitingNCT07329556
- Mobile App-Based Infection Monitoring in Familial Mediterranean FeverEnrolling by invitationNCT072127641 country
- Prevalence of Oral Findings in Egyptian Patients Diagnosed With Familial Mediterranean FeverNot yet recruitingNCT072480591 country
- Mediterranean Diet in Familial Mediterranean Fever: Is Fatty Liver Affected by Addition of Aerobic ExerciseRecruitingNCT07130318Not applicable1 country
- Outcomes of Inspiratory Muscle Training in FMF AdolescentsRecruitingNCT07129538Not applicable1 country
- is There an Effect of Adding Body Vibration to Intake of Vitamin D on Some Outcomes of Familial Mediterranean FeverRecruitingNCT07130305Not applicable1 country
- Randomized Controlled Trial in Patients on Long-term Colchicine With Colchicine-resistant Familial Mediterranean Fever (FMF) to Evaluate the Efficacy of On-demand Anakinra Treatment for Painful Attacks in Patients Who Refuse Continuous Daily TherapyRecruitingNCT06336733Phase 31 country
- Can Gluten/Wheat or Other Foods be Responsible for FMF AttacksRecruitingNCT063388911 country
- Comparing Structured Neuromuscular Exercise and Exergaming Program in Adolescents With Familial Mediterranean FeverEnrolling by invitationNCT07013045Not applicable1 country
- Physical Activity in Adolescents With Familial Mediterranean FeverNot yet recruitingNCT069749421 country
- Investigation of the Validity, Reliability and Responsiveness of the BETY-BQ in FMFNot yet recruitingNCT068302131 country
- Comparison of the Effects of Synchronous and Asynchronous Telerehabilitation in Patients with Juvenile Familial Mediterranean FeverNot yet recruitingNCT06743152Not applicable1 country
- Safety and Efficacy of RPH-104 Used to Prevent Recurrent Fever Attacks in Adult Patients With Colchicine Resistant or Colchicine Intolerant Familial Mediterranean FeverRecruitingNCT05190991Phase 23 countries
- Barriers to Physical Activity in Familial Mediterranean FeverNot yet recruitingNCT067258491 country
- Gait Profile and Variables in Pediatric Rheumatic Disease Using a Smart Insole SystemNot yet recruitingNCT06705673
- Hematological Indices in Pediatric Diagnosed with Familial Mediterranean FeverNot yet recruitingNCT06583304
- Characterization of a Functional Test for Mediterranean Family Fever Screening - 2RecruitingNCT044784091 country
- Assessment of microRNAs Role in Familial Mediterranean Fever FMF PathophysiologyNot yet recruitingNCT06033339Not applicable1 country
- Evaluation of Bone Metabolism in Children and Adolescents With Familial Mediterranean FeverRecruitingNCT060347951 country
- Caspase-1 Activity, IL-1beta, and IL-18 in Patients With FMFCompletedNCT069815201 country
- A Study to Evaluate Efficacy and Safety of Anakinra in Chinese Patients With Colchicine-resistent FMFWithdrawnNCT06666335Phase 4
- Comparison Of The Effects Of Two Different Exercise Training Based On Internal And External Focus In Children and Adolescents With Rheumatic DiseasesCompletedNCT07138157Not applicable1 country
- Health-related Quality of Life, Electrocardiographic and Holter Findings in Children With Familial Mediterranean FeverActive, not recruitingNCT071282251 country
- Kinesiophobia in Familial Mediterranean FeverCompletedNCT053985361 country
- Assessment of Cardiorespiratory Fitness Using the PACER in Patients With Juvenile Idiopathic Arthritis and Familial Mediterranean FeverCompletedNCT066970281 country
- A Study to Describe a Group of Spanish Patients With FMF and to Identify Suboptimally Treated Patients With Minimal Disease Activity and Its Impact on Quality of LifeCompletedNCT069231241 country
- Efficacy and Safety of RPH-104 for Resolution and Prevention of Recurring Attacks in Adult Subjects With Familial Mediterranean Fever With Resistance to or Intolerance of ColchicineActive, not recruitingNCT05092776Phase 24 countries
- Study of Colchicine Resistance in Familial Mediterranean FeverCompletedNCT05418686Not applicable1 country
- Heat Intolerance in the Group of FMF PatientsTerminatedNCT010592791 country
- Kineret (Anakinra), in Adult Patients With Colchicine-Resistant Familial Mediterranean FeverCompletedNCT01705756Phase 31 country
- Physical Abilities of Teenagers With Familial Mediterranean FeverActive, not recruitingNCT062573421 country
- A Study to Evaluate RIST4721 in Familial Mediterranean Fever (FMF)WithdrawnNCT05448391Phase 2
- Central Sensitization in Familial Mediterranean Fever (FMF)CompletedNCT051771201 country
- Investigation of Autonomic Dysfunction in Patients With Familial Mediterranean FeverStatus unknownNCT055966431 country
- Clinical and Molecular Evaluation of Childern With Familial Meditterranean Fever and Their SiblingsStatus unknownNCT05488561Not applicable1 country
- The Movement Imagery Ability in Patients With Familial Mediterranean FeverCompletedNCT047292181 country
- A Diagnostic Test for Familial Mediterranean FeverCompletedNCT037473151 country
- Effects of Online Aerobic Exercise Training and Physical Activity Counseling in Juvenile Familial Mediterranean FeverStatus unknownNCT04724993Not applicable1 country
- Tocilizumab for the Treatment of Familial Mediterranean FeverCompletedNCT03446209Phase 21 country
- Gluten-related Disorders in Familial Mediterranean Fever PatientsCompletedNCT03563300Not applicable1 country
- Musculoskeletal Ultrasound of the Ankles in Erysipelas-like Erythema of Familial Mediterranean FeverStatus unknownNCT03917277Not applicable1 country
- Inflammatory Proteins in Familial Mediterranean Fever During Attack and RemissionWithdrawnNCT003234401 country