Endometrial Hyperplasia clinical trials
The registry lists 110 studies for Endometrial Hyperplasia across more than 10 countries. 38 are recruiting or about to start. 63 of them are mainly about Endometrial Hyperplasia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-05.
Get an email when these change. Save the Endometrial Hyperplasia studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
Xiaojun Chen (7) · Peking University People's Hospital (5) · Fudan University (4) · Imperial College London (3) · University of Campania Luigi Vanvitelli (3) · National Cancer Institute (NCI) (3) · Milton S. Hershey Medical Center (3) · Korean Gynecologic Oncology Group (2)
What is being tested here
Drugs under test in Endometrial Hyperplasia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Tirzepatide | 4 | 0 | 4 |
| Megestrol Acetate | 2 | 4 | 10 |
| Megestrol | 2 | 4 | 10 |
| Letrozole | 2 | 3 | 3 |
| Semaglutide | 2 | 0 | 3 |
| Atorvastatin | 2 | 0 | 2 |
| Metformin | 1 | 1 | 6 |
| Levonorgestrel | 1 | 2 | 4 |
| Medroxyprogesterone Acetate | 1 | 0 | 3 |
| Medroxyprogesterone | 1 | 0 | 3 |
Drug classes tested here GLP-1 receptor agonists 5 open · Hormonal contraceptives 2 open · Aromatase inhibitors 2 open · Statins 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4
- Jul 2027Pipelle® Under Ultrasound Guidance (PUG) to Investigate Post-menopausal Bleeding. · Imperial College Healthcare NHS Trust
- Jul 2027Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer · Mayo Clinic
- Aug 2027Liquid Biopsy-Based Early Screening for Endometrial Cancer in Regional Chinese Populations · Guizhou Provincial People's Hospital
- Sep 2027Orlistat Plus Progestin for Fertility-Sparing Treatment of Endometrial Cancer or Atypical Hyperplasia · Peking University People's Hospital
Who these studies take
Of the 21 Endometrial Hyperplasia studies recruiting now, 9 (43%) set no upper age limit and 11 (52%) stop at 75 or younger. 7 (33%) take children under 18. 20 (95%) are for women only and 0 (0%) for men only; 3 (14%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (19%) | 1 (5%) |
| 18 | 20 (95%) | 1 (5%) |
| 30 | 20 (95%) | 1 (5%) |
| 40 | 19 (90%) | 1 (5%) |
| 50 | 10 (48%) | 1 (5%) |
| 65 | 10 (48%) | 1 (5%) |
| 75 | 10 (48%) | 1 (5%) |
| 85 | 9 (43%) | 1 (5%) |
Across all 110 studies, recruiting or not: 45% stop at 75 or younger and 38% at 65; 15% take children; 98% are for women only and 0% for men only; 16% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 50 of 110. Browse all 110 → or search them.
- Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical CancerRecruitingNCT050517221 country
- Liquid Biopsy-Based Early Screening for Endometrial Cancer in Regional Chinese PopulationsRecruitingNCT078927551 country
- Canagliflozin Plus Progestin for Atypical Endometrial Hyperplasia and Early-Stage Endometrial CancerNot yet recruitingNCT07890064Phase 21 country
- A Study to Estimate Early Clinical Efficacy Signals of GLP-1 Agonist Administration in Conjunction With Levonorgestrel Intrauterine Device in Obese Patients With Endometrioid Intraepithelial NeoplasiaRecruitingNCT07107334Phase 21 country
- Semaglutide, Weight Loss, and LNG-IUD for Conservative Treatment of Endometrial Atypical Hyperplasia and Grade 1 Endometrial CancerNot yet recruitingNCT07820358Phase 21 country
- Tirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1 Endometrial CancerNot yet recruitingNCT07078838Phase 21 country
- GnRHa + Letrozole in Non-obese Progestin-insensitive Endometrial Cancer and Atypical Hyperplasia PatientsRecruitingNCT05316935Phase 2/31 country
- GnRHa + Letrozole in Obese Progestin-insensitive Endometrial Cancer PatientsRecruitingNCT06379113Phase 2/31 country
- Tirzepatide and Levonorgestrel IUD Therapy for EIN and Early-Stage Endometrial CancerNot yet recruitingNCT07812636Early Phase 11 country
- Concurrent Laparoscopic Hysterectomy and Weight Loss Surgery in Obese Patients With Endometrial Carcinoma or Endometrial Intraepithelial NeoplasiaRecruitingNCT04839614Not applicable1 country
- A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial CancerNot yet recruitingNCT07349641Phase 21 country
- Mazdutide Plus LNG-IUS for Fertility-Sparing Treatment of AEH or Early Endometrial CancerNot yet recruitingNCT07781150Phase 21 country
- InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for CancerRecruitingNCT054637961 country
- Orlistat Plus Progestin for Fertility-Sparing Treatment of Endometrial Cancer or Atypical HyperplasiaNot yet recruitingNCT07714070Phase 21 country
- Progestins for the Treatment of Endometrial Cancer or Precancers of the Uterus Before Surgery, The Pro-Window TrialRecruitingNCT07436793Phase 21 country
- SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial CancerNot yet recruitingNCT07462663Phase 4
- Weight Management Plus LNG-IUS/Megestrol Acetate in Endometrial Atypical HyperplasiaRecruitingNCT05316493Phase 2/31 country
- Measurement of Urinary Hormones in Patients With Abnormal Uterine Bleeding to Study Uterine Cancer ProgressionNot yet recruitingNCT075812881 country
- Intrauterine Injection of Type III Collage in FST of EC/AEHRecruitingNCT07377734Phase 21 country
- Uterine Preservation Via Lifestyle TransformationRecruitingNCT05903131Phase 21 country
- Cervical Cytology DNA Methylation for Endometrial Lesion Screening and Follow-upNot yet recruitingNCT07298707
- POPQ Associated With Total Laparoscopic HysterectomyNot yet recruitingNCT071372991 country
- Surgical and Obstetric Outcomes in Endometrial Adenocarcinoma and Atypical Endometrial Hyperplasia With Conservative TreatmentRecruitingNCT070778761 country
- Cohort Study of Intrauterine DiseasesRecruitingNCT070483271 country
- Ultrasound and Histology in AEH and Early EEC Treated ConservativelyNot yet recruitingNCT070282421 country
- Patient-derived Tumor-like Cell Clusters Predict Progesterone Sensitivity in Patients With Early Endometrial CancerRecruitingNCT056471091 country
- Progesterone Therapeutic Regimen Plus Statins in Young Women With Early Endometrial Carcinoma and Atypical Endometrial HyperplasiaRecruitingNCT06102863Phase 21 country
- A Multi-center Prospective Study on the Oncological and Reproductive Outcomes and Quality of Life in Young Woman After Fertility-sparing Treatment of Endometrial Cancer and Endometrial Intraepithelial HyperplasiaNot yet recruitingNCT06745427
- Pipelle® Under Ultrasound Guidance (PUG) to Investigate Post-menopausal Bleeding.RecruitingNCT06501846Not applicable1 country
- Medroxyprogesterone Acetate Plus Atorvastatin in Young Women With Early Endometrial Carcinoma and Atypical Endometrial HyperplasiaRecruitingNCT05675787Phase 21 country
- Prospective Study for Endometrial Carcinoma and Hyperplasia in Childbearing-age WomenRecruitingNCT06417736Not applicable1 country
- The Use of Etonogestrel Contraceptive Implant as Treatment for Endometrial Hyperplasia Without Atypia: A Cohort StudyNot yet recruitingNCT06378489
- Effect of Stress Ball Use on Anxiety Level During Endometrial Biopsy ProcedureNot yet recruitingNCT06171581Not applicable
- Conservative Treatment for Atypical Endometrial Hyperplasia and Early Endometrial CancerNot yet recruitingNCT06170684
- Predictors of Ovarian Cancer and Endometrial Cancer for Artificial-Intelligence-Based Screening ToolsRecruitingNCT056976011 country
- Endometrial Cancer Screening in High-risk PopulationsNot yet recruitingNCT06125886Not applicable
- Fertility Sparing Management of EndomeTrial Cancer and HyperplasiaRecruitingNCT04362046Not applicable1 country
- Value of LNG-IUS as Fertility-preserving Treatment of EAH and ECRecruitingNCT03463252Phase 2/31 country
- Levonorgestrel-Releasing Intrauterine System in Treating Patients With Complex Atypical Hyperplasia or Grade I Endometrial CancerActive, not recruitingNCT00788671Phase 21 country
- Longitudinal Follow-up in Women With Endometrial Hyperplasia Without AtypiaCompletedNCT05292573Phase 31 country
- Endometrial Cancer Vaginal Fluid Specimen Collection StudyActive, not recruitingNCT075446801 country
- Levonorgestrel-Releasing Intrauterine System With or Without Everolimus in Treating Patients With Atypical Hyperplasia or Stage IA Grade 1 Endometrial CancerActive, not recruitingNCT02397083Phase 21 country
- Mirena for the Treatment of Nonatypical Endometrial Hyperplasia for 6 MonthsWithdrawnNCT06904274Phase 33 countries
- Megestrol Acetate With or Without Pterostilbene in Treating Patients With Endometrial Cancer Undergoing HysterectomyActive, not recruitingNCT03671811Phase 21 country
- Endometrial Cell Collection With the PadKitCompletedNCT06464107Not applicable1 country
- Loxenatide Plus LNG-IUS in Endometrial Atypical HyperplasiaCompletedNCT05172999Phase 2/31 country
- Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial CancerActive, not recruitingNCT04576104Phase 21 country
- Primary Prevention and Uterine Preservation in Premenopausal Women With Obesity and Endometrial HyperplasiaWithdrawnNCT05829460Phase 2
- Effect of Metformin on Endometrial Thickness in Postmenopausal Breast Cancer Patients Receiving TamoxifenCompletedNCT07145827Not applicable1 country
- Exemestane in Treating Patients With Complex Atypical Hyperplasia of the Endometrium/Endometrial Intraepithelial Neoplasia or Low Grade Endometrial CancerCompletedNCT03300557Phase 21 country