Empyema clinical trials
The registry lists 56 studies for Empyema across more than 10 countries. 13 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-07-20.
Status
- Completed
- 29
- Status unknown
- 11
- Recruiting
- 9
- Not yet recruiting
- 4
- Terminated
- 2
- Withdrawn
- 1
Phase
- Phase 3
- 9
- Phase 4
- 6
- Phase 2
- 4
- Phase 1
- 1
Where
- United States
- 13
- Egypt
- 5
- United Kingdom
- 4
- Italy
- 3
- China
- 3
- Spain
- 3
Who runs them
Assiut University (3) · Centre Hospitalier Universitaire, Amiens (2) · Beijing Children's Hospital (2) · Chinese University of Hong Kong (2) · Children's Mercy Hospital Kansas City (2) · Azienda Ospedaliera di Padova (1) · Association Clinique Thérapeutique Infantile du val de Marne (1) · National Institutes of Health Clinical Center (CC) (1)
Studies
Recruiting first, then most recently updated. Showing 50 of 56 — search for more.
- Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or EmpyemaRecruitingNCT07095361Phase 41 country
- Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and EmpyemasRecruitingNCT06427538Not applicable1 country
- UNC Pleural Fluid RegistryRecruitingNCT056203291 country
- Diagnostic Utility of Pleural Infection-specific Multiplex PCR PanelNot yet recruitingNCT070770961 country
- Effectiveness and Safety of Sodium Bicarbonate Pleural Lavage in the Treatment of Complex Pleural EffusionRecruitingNCT06734481Not applicable1 country
- Comparative Study Between Outcome of ICT Drainage and VATS in Management of Second Stage EmpyemaNot yet recruitingNCT06680024Not applicable
- Complicated Pneumonia (CP) in Children in South-East EuropeRecruitingNCT066578981 country
- Pediatric Video Assisted Thoracoscopic Surgery (VATS) in Management of EmpyemaRecruitingNCT06424457Not applicable1 country
- Pneumonia and Empyema in Emergency Departments in ChildrenRecruitingNCT052746071 country
- Is Intercostal Tube Enough in Management of EmpyemaNot yet recruitingNCT06235359Not applicable
- VATS Decortication Versus IR Guided Chest Tube Insertion With Fibrinolytics for the Management of EmpyemaRecruitingNCT03584113Not applicable1 country
- Medical Thoracoscopy in Treatment Outcomes of Empyema ManagementNot yet recruitingNCT06132997Not applicable
- Comparison Between McGrath and Macintosh Laryngoscopes for DLT Intubation in Thoracic Surgery Patients.RecruitingNCT05988736Not applicable1 country
- Chemical vs Mechanical Pleural Adhesiolysis for Liberation of Captive Pleura in Stacked EffusionCompletedNCT07713329Phase 21 country
- Pharmacokinetics and Pleural Fluid Penetration of Amoxicillin and Clavulanic Acid in Patients With Pleural InfectionsCompletedNCT04350502Not applicable1 country
- Comparison of Lung Expansion After Uniportal and Multiportal Video Assisted Thoracic Surgery for Stage II Post Pneumonic Bacterial Empyema ThoracisCompletedNCT07137507Not applicable1 country
- The Oxford Pleural Infection Endotyping StudyCompletedNCT065136891 country
- Uniportal VATS Versus Chest Tube for Early EmpyemaCompletedNCT06325904Not applicable1 country
- The Role of Surgery in Patients With Coronavirus Disease - 19 (COVID-19) Related Thoracic ComplicationsCompletedNCT052045375 countries
- Prospective Evaluation of 14F Thal Tube vs 28 French Chest Tube for Hemothorax and Use of Maximum Barrier PrecautionsCompletedNCT03167723Not applicable1 country
- Management of Pleural Space InfectionsCompletedNCT03873766Phase 41 country
- Treatment of Complicated Parapneumonic Effusion With Fibrinolytic Therapy Versus VATs DecorticationCompletedNCT03583931Not applicable1 country
- A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General AnesthesiaStatus unknownNCT05077111Phase 41 country
- Early Laparoscopic Cholecystectomy Versus Percutaneous Cholecystostomy in Grade II Acute Cholecystitis GuidelinesCompletedNCT04979936Not applicable1 country
- Short Duration High Intensity Intrapleural Alteplase With Pulmozyme in Pleural Infection ManagementCompletedNCT04915586Not applicable1 country
- Fibrinolysis Compared to Thoracoscopy for Pleural InfectionCompletedNCT03468933Phase 41 country
- Clinical Feature and Microbiology Characteristics of Empyema in ChildrenStatus unknownNCT046952751 country
- Retrospective Review on Patients With Culture Negative EmpyemaCompletedNCT044779801 country
- Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA Trial)CompletedNCT01717742Phase 31 country
- Suturing With U-Technique Versus Un-Reapproximated Wound Edges During Removal of Closed Thoracostomy Tube DrainStatus unknownNCT04193241Not applicable1 country
- VATS ( Video-Assisted Thoracoscopy) Compared to Reinsertion of a Thoracostomy Tube for Persistent HaemothoraxCompletedNCT02014077Not applicable1 country
- Early Results of Empyema Thoracis Treatment in Children by Video-assisted Thoracoscopic SurgeryStatus unknownNCT041775501 country
- Medical Thoracoscopy Versus Tube Thoracostomy in Management of Empyema .Status unknownNCT03859206Not applicable
- Chest Wall Motion Analysis in DiseaseCompletedNCT029586831 country
- Efficacy of Fibrinolytic Agents in Complicated Pleural EffusionStatus unknownNCT03716375Not applicable
- Comparison of Intrapleural Urokinase and Video-Assisted Thorascopic Surgery in the Treatment of Parapneumonic Pleural Effusion in ChildrenStatus unknownNCT02165891Phase 31 country
- Comparing Xperguide vs. Conventional Methods During Percutaneous Image Guided ProceduresTerminatedNCT01287013Not applicable1 country
- Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical ThoracoscopyCompletedNCT02446782Phase 41 country
- Procalcitonin in Pleural PleuritisCompletedNCT010118811 country
- Early Medical Thoracoscopy Versus Simple Chest Tube Drainage in Complicated Parapneumonic Effusion and Pleural EmpyemaTerminatedNCT00234208Phase 33 countries
- The Osteogenic Potential of Human Maxillary Sinus Shneiderian MembraneCompletedNCT026769211 country
- Empyema Treated With tPA & DNAseWithdrawnNCT01862458Phase 31 country
- Clinical Trial Corticoids For Empyema And Pleural Effusion In ChildrenCompletedNCT01261546Phase 21 country
- Effects of Drainage in Laparoscopic CholecystectomyCompletedNCT02027402Not applicable1 country
- KatGuide Method Versus Conventional Method at Insertion of Chest TubeCompletedNCT01522885Phase 31 country
- Empyema Following Pneumonectomy for Non Small Cell Lung Cancer (NSCLC)CompletedNCT018371861 country
- Drainage is Not Necessary Procedure After Laparoscopic Cholecystectomy Due to Severe Acute CholecystitisStatus unknownNCT01625247Phase 31 country
- Efficacy and Safety of Activase (Ateplase) vs Placebo in Complicated Pleural Effusions (CPE)/EmpyemasCompletedNCT00468104Not applicable1 country
- Procoagulant Activity in Patients With Community Acquired Pneumonia, Pleural Effusion and EmpyemaCompletedNCT011785801 country
- Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and EmpyemaCompletedNCT01246453Phase 41 country