Empyema, Pleural clinical trials
The registry lists 33 studies for Empyema, Pleural across more than 10 countries. 11 are recruiting or about to start. 25 of them are mainly about Empyema, Pleural (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Who runs them
University of Health Sciences Lahore (3) · Assiut University (2) · University of Milano Bicocca (1) · Delta University for Science and Technology (1) · Swedish Medical Center (1) · University of Ibadan (1) · University of Arizona (1) · Fayoum University (1)
What is being tested here
Drugs under test in Empyema, Pleural studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5
- Dec 2026Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas · Vanderbilt University Medical Center
- Dec 2026Fungal Empyema Thoracis · University of Health Sciences Lahore
- Apr 2027Flush, Lyse, Operate · Dartmouth-Hitchcock Medical Center
- Jul 2027Evaluating Antibiotic Course Upon Adequate Treatment of Empyema · University of Arizona
- Oct 2027VATS Surgery Compared to Drainage in the Treatment of Pleural Empyema · Thomas Decker Christensen
Who these studies take
Of the 9 Empyema, Pleural studies recruiting now, 6 (67%) set no upper age limit and 3 (33%) stop at 75 or younger. 3 (33%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (33%) | 3 (33%) |
| 18 | 9 (100%) | 9 (100%) |
| 30 | 7 (78%) | 7 (78%) |
| 40 | 7 (78%) | 7 (78%) |
| 50 | 7 (78%) | 7 (78%) |
| 65 | 7 (78%) | 7 (78%) |
| 75 | 6 (67%) | 6 (67%) |
| 85 | 6 (67%) | 6 (67%) |
Across all 33 studies, recruiting or not: 33% stop at 75 or younger and 27% at 65; 30% take children; 0% are for women only and 0% for men only; 12% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- VATS or Intrapleural Enzymatic Therapy for Patients With Empyema.Oct 26, 2026NCT07886541
Newly registered1
- VATS or Intrapleural Enzymatic Therapy for Patients With Empyema.Oct 21, 2026NCT07886541
Studies
Recruiting first, then most recently updated. Showing 33 of 33. search them.
- VATS or Intrapleural Enzymatic Therapy for Patients With Empyema.RecruitingNCT07886541Phase 41 country
- Evaluating Antibiotic Course Upon Adequate Treatment of EmpyemaNot yet recruitingNCT07862361Not applicable1 country
- Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or EmpyemaRecruitingNCT07095361Phase 41 country
- Flush, Lyse, OperateNot yet recruitingNCT07592520Phase 41 country
- Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and EmpyemasRecruitingNCT06427538Not applicable1 country
- Fungal Empyema ThoracisRecruitingNCT07337993Not applicable1 country
- VATS Surgery Compared to Drainage in the Treatment of Pleural EmpyemaRecruitingNCT04095676Not applicable1 country
- Complicated Pneumonia (CP) in Children in South-East EuropeRecruitingNCT066578981 country
- Pediatric Video Assisted Thoracoscopic Surgery (VATS) in Management of EmpyemaRecruitingNCT06424457Not applicable1 country
- VATS Decortication Versus IR Guided Chest Tube Insertion With Fibrinolytics for the Management of EmpyemaRecruitingNCT03584113Not applicable1 country
- Comparison Between McGrath and Macintosh Laryngoscopes for DLT Intubation in Thoracic Surgery Patients.RecruitingNCT05988736Not applicable1 country
- Chemical vs Mechanical Pleural Adhesiolysis for Liberation of Captive Pleura in Stacked EffusionCompletedNCT07713329Phase 21 country
- Trial of Antiseptic Irrigation for Pleural InfectionCompletedNCT05546762Phase 21 country
- Evaluation of Efficacy and Safety Parameters of Different Antibiotics Regimens for Management of EmpyemaCompletedNCT06787885Not applicable1 country
- The Role of Decortication in Complex Empyema Cases: Multidrug Resistance and Tuberculosis at the ForefrontCompletedNCT071678231 country
- Comparison of Lung Expansion After Uniportal and Multiportal Video Assisted Thoracic Surgery for Stage II Post Pneumonic Bacterial Empyema ThoracisCompletedNCT07137507Not applicable1 country
- The Oxford Pleural Infection Endotyping StudyCompletedNCT065136891 country
- Uniportal VATS Versus Chest Tube for Early EmpyemaCompletedNCT06325904Not applicable1 country
- The Role of Surgery in Patients With Coronavirus Disease - 19 (COVID-19) Related Thoracic ComplicationsCompletedNCT052045375 countries
- Management of Pleural Space InfectionsCompletedNCT03873766Phase 41 country
- Treatment of Complicated Parapneumonic Effusion With Fibrinolytic Therapy Versus VATs DecorticationCompletedNCT03583931Not applicable1 country
- Local Anesthesia Versus Combined Local Anesthesia With Single Dose Analgesia on Pain Control During Thoracic Ultrasound Guided ProceduresStatus unknownNCT05121233Phase 4
- A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General AnesthesiaStatus unknownNCT05077111Phase 41 country
- Retrospective Review on Patients With Culture Negative EmpyemaCompletedNCT044779801 country
- Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA Trial)CompletedNCT01717742Phase 31 country
- Suturing With U-Technique Versus Un-Reapproximated Wound Edges During Removal of Closed Thoracostomy Tube DrainStatus unknownNCT04193241Not applicable1 country
- Chest Wall Motion Analysis in DiseaseCompletedNCT029586831 country
- Efficacy of Fibrinolytic Agents in Complicated Pleural EffusionStatus unknownNCT03716375Not applicable
- Comparison of Intrapleural Urokinase and Video-Assisted Thorascopic Surgery in the Treatment of Parapneumonic Pleural Effusion in ChildrenStatus unknownNCT02165891Phase 31 country
- Procalcitonin in Pleural PleuritisCompletedNCT010118811 country
- Early Medical Thoracoscopy Versus Simple Chest Tube Drainage in Complicated Parapneumonic Effusion and Pleural EmpyemaTerminatedNCT00234208Phase 33 countries
- Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and EmpyemaCompletedNCT01246453Phase 41 country
- Dornase Alfa and Urokinase for Kids With Pleural EmpyemaStatus unknownNCT00502632Phase 2/31 country