Eisenmenger Complex clinical trials
The registry lists 23 studies for Eisenmenger Complex across more than 10 countries. 5 are recruiting or about to start. 15 of them are mainly about Eisenmenger Complex (how this is decided). Per ClinicalTrials.gov, last updated 2026-05-01.
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Who runs them
Actelion (3) · University of California, Los Angeles (2) · Competence Network for Congenital Heart Defects (2) · Rigshospitalet, Denmark (2) · Federal University of São Paulo (2) · Centre Chirurgical Marie Lannelongue (1) · Kazuya Hosokawa (1) · Copenhagen University Hospital, Rigshospitalet (1)
What is being tested here
Drugs under test in Eisenmenger Complex studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Sotatercept | 2 | 0 | 2 |
| Pentoxifylline | 1 | 0 | 1 |
| Macitentan | 0 | 2 | 2 |
| Sildenafil | 0 | 2 | 2 |
| Bosentan | 0 | 1 | 1 |
| Iloprost | 0 | 0 | 1 |
| Citrulline malate | 0 | 0 | 1 |
| Citrulline | 0 | 0 | 1 |
Drug classes tested here Endothelin receptor antagonists 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 2
- Dec 2026COMPERA / COMPERA-KIDS · Technische Universität Dresden
- Aug 2027A Study of Sotatercept for Patients With Eisenmenger Syndrome or Unrepaired Shunt-Associated Pulmonary Arterial Hypertension Resistant to Vasodilator Therapy · Kazuya Hosokawa
Who these studies take
Of the 4 Eisenmenger Complex studies recruiting now, 2 (50%) set no upper age limit and 0 (0%) stop at 75 or younger. 2 (50%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (50%) | 2 (50%) |
| 18 | 4 (100%) | 4 (100%) |
| 30 | 4 (100%) | 4 (100%) |
| 40 | 4 (100%) | 4 (100%) |
| 50 | 4 (100%) | 4 (100%) |
| 65 | 4 (100%) | 4 (100%) |
| 75 | 4 (100%) | 4 (100%) |
| 85 | 2 (50%) | 2 (50%) |
Across all 23 studies, recruiting or not: 9% stop at 75 or younger and 4% at 65; 48% take children; 0% are for women only and 0% for men only; 0% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 23 of 23. search them.
- Sota-ES - Sotatercept in Patients With Congenital Heart Disease and Eisenmenger´s SyndromeNot yet recruitingNCT07498803Phase 2
- A Study of Sotatercept for Patients With Eisenmenger Syndrome or Unrepaired Shunt-Associated Pulmonary Arterial Hypertension Resistant to Vasodilator TherapyRecruitingNCT07356778Phase 41 country
- COMPERA / COMPERA-KIDSRecruitingNCT013472164 countries
- Pentoxifylline as an Adjunct Therapy for Patients With Eisenmenger SyndromeRecruitingNCT05611268Not applicable1 country
- Respiratory and Physical Therapy in Patients With Associated Pulmonary Arterial Hypertension (APAH) With Congenital Heart DefectsRecruitingNCT01397110Not applicable1 country
- 4DFlow Magnetic Resonance Imaging in Patients With Pulmonary Hypertension Associated With Congenital Heart DiseaseCompletedNCT03928002Not applicable1 country
- Eisenmenger Quality Enhancement Research InitiativeCompletedNCT01623492
- Real World Difference After Changing Medication From Nonselective to Selective Endothelin Receptor Antagonist in Stable Eisenmenger SyndromeStatus unknownNCT04732650
- Transcatheter Valve Implantation in Patients With Dysfunctional Left and Right Sided Heart ValvesCompletedNCT02119442Not applicable1 country
- Clinical Study to Assess the Long-term Safety, Tolerability, and Efficacy of Macitentan in Subjects With Eisenmenger SyndromeTerminatedNCT01739400Phase 319 countries
- Clinical Study to Evaluate the Effects of Macitentan on Exercise Capacity in Subjects With Eisenmenger SyndromeCompletedNCT01743001Phase 321 countries
- Six Minutes Walk Test and Shuttle Walk Test in Eisenmenger SyndromeStatus unknownNCT027523991 country
- Effects Oxygen Supplementation Determined Better Exercise Capacity in Eisenmenger SyndromeCompletedNCT02661802Not applicable
- Eisenmenger Syndrome in the Nordic CountriesStatus unknownNCT019765334 countries
- Sleep-disordered Breathing in Eisenmenger SyndromeCompletedNCT02614417
- Iloprost for the Treatment of Pulmonary Hypertension in Adults With Congenital Heart DiseaseTerminatedNCT01319045Not applicable1 country
- Eisenmenger's Syndrome in Adults With CHDCompletedNCT002669031 country
- Exercise Capacity and Quality of Life in Patients With PPH Receiving Short Term Oral L-Citrulline MalateStatus unknownNCT01683981Early Phase 11 country
- Therapy of Pulmonary Arterial Hypertension (PAH) - Treatment With Sildenafil in Eisenmenger PatientsTerminatedNCT00586794Phase 31 country
- The Effects of Inhaled Iloprost on Congenital Heart Disease With Eisenmenger SyndromeCompletedNCT01283958
- Phosphodiesterase-5 Inhibitor in Eisenmenger SyndromeCompletedNCT01200732Phase 21 country
- Bosentan in Treatment of Pulmonary Arterial HypertensionCompletedNCT00266162Phase 41 country
- Combination Treatment With Bosentan and Sildenafil to Patients With Eisenmengers SyndromeCompletedNCT00303004Phase 31 country