An interventional study of respiratory and exercise therapy in Pulmonary Arterial Hypertension and Eisenmenger Syndrome, sponsored by Heidelberg University. Recruiting at 1 site in Germany. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2022-07-14.
Sponsored by Heidelberg University · Not applicable, Interventional, and Supportive care
The purpose of this study is to investigate the influence of physical training on exercise capacity, quality of life, functional class, oxygen consumption and right ventricular function in patients with severe associated pulmonary arterial hypertension (APAH) as part of a congenital heart defect with / without Eisenmenger's Syndrome
699 studies on the registry are indexed under Pulmonary Arterial Hypertension; 140 are open to participants now.
This study's planned enrollment of 50 is above the median of 40 across 477 interventional studies indexed under Pulmonary Arterial Hypertension.
Browse Pulmonary Arterial Hypertension studies →Heidelberg University is the lead sponsor of 287 studies on the registry; 19 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
From a breathing test (spirometry): how much air you can blow out in the first second. Often given as a percentage of what is expected for your age, height and sex.
FEV1
From a breathing test (spirometry): how much air you can blow out in the first second. Often given as a percentage of what is expected for your age, height and sex.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Randomized, prospective, controlled, blinded study of three-week inpatient rehabilitation and subsequent continuing of the training at home for 12 weeks. The control group received conventional rehabilitation without a specific training program. After 15 weeks training is also offered to patients in the control group.
Other: respiratory and exercise therapy
patients of the control group continue their sedentary lifestyle without given advice for exercise training. The time before start of rehabilitation (three months) serves as control group. Afterwards patients take part in the training program as well.
Conventional therapy with specific respiratory and physical therapy plus mental walking training
Changes in the maximum 6-minute walk distance (6MGT)
Time frame: up to 15 weeks
Changes in quality of life
Time frame: up to 15 weeks
Changes in hemodynamics
1. Changes in maximum oxygen uptake 2. Changes in exercise capacity: 6-minute walk distance, Recumbent Bike (Watts), respiratory economy (EQO2, EQCO2) 3. Improved condition(NYHA class, Borg scale) 4. Changes in Magnetic resonance tomography and echocardiographic parameters of right and left ventricle: size and pump function. 5. Change of laboratory parameters, which are markers of right heart failure as NTproBNP, interleukins
Time frame: up to 15 weeks
The record gives a start of Jan 2012, a primary completion of Dec 2025 and a completion of Dec 2025. It does not say whether these dates are actual or estimated.
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Pulmonary Arterial Hypertension →