Depressive Disorder, Major: all 2,805 studies

Page 7 of 29. Open to participants first (565), then studies with results posted, then the rest; newest registration first within each.

• Intensive tDCS for MDD: Feasibility StudyCompletedNCT05194267Not applicableResults posted
• KAP for Depression in Abstinent Opioid UsersTerminatedNCT05193318Phase 2Results posted
• Study to Evaluate the Efficacy and Safety of Once-Weekly Oral NBI-1065846 in the Treatment of Anhedonia in MDDCompletedNCT05165394Phase 2Results posted
• Investigating the Causal Role of Prefrontal Control in Decision-making in Patients With AnhedoniaCompletedNCT05084924Not applicableResults posted
• A Study to Assess the Efficacy and Safety of REL-1017 as Monotherapy for Major Depressive Disorder (MDD)CompletedNCT05081167Phase 3Results posted
• An Open-label Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive DisorderCompletedNCT05061719Phase 3Results posted
• Multicenter Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive DisorderCompletedNCT05061706Phase 3Results posted
• Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic TargetsCompletedNCT05046184Phase 2Results posted
• HypErthermia as an Additional Treatment for the Biology and Experience of DepressionCompletedNCT05041361Not applicableResults posted
• Vagal Nerve Stimulation for Treatment Resistant Major DepressionCompletedNCT04990687Not applicableResults posted
• Clinical Trial of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive DisorderCompletedNCT04985942Phase 3Results posted
• Targeting IL-17A for Treatment-Resistant DepressionCompletedNCT04979910Phase 2Results posted
• A Novel Cognitive Remediation Intervention Targeting Poor Decision-making and Depression in Veterans at High Risk for Suicide: A Safe, Telehealth Approach During the COVID-19 PandemicCompletedNCT04952532Not applicableResults posted
• Feasibility of Adherence to Light TherapyTerminatedNCT04944758Not applicableResults posted
• A Study to Test How Well Different Doses of BI 1569912 Are Tolerated and How Well They Work in People With Depression Who Take Anti-depressive MedicationCompletedNCT04937829Phase 1Results posted
• Use of a Digitally Enabled App With Clinical Team Interface in the Management of DepressionCompletedNCT04891224Not applicableResults posted
• Safety of REL-1017 for Major Depressive DisorderCompletedNCT04855760Phase 3Results posted
• A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD)TerminatedNCT04855747Phase 3Results posted
• Stress and the Sympathetic Nervous System in Adults With DepressionCompletedNCT04838262Not applicableResults posted
• Brexpiprazole as Adjunctive Therapy in Adults With Major Depressive DisorderCompletedNCT04830215Phase 4Results posted
• A Long-Term Extension Study for Participants With Treatment-resistant Major Depressive Disorder Who Are Continuing Esketamine Nasal Spray TreatmentCompletedNCT04829318Phase 4Results posted
• Antidepressant Effects of TS-161 in Treatment-Resistant DepressionTerminatedNCT04821271Phase 2Results posted
• Home-based tDCS in Major Depressive DisorderCompletedNCT04799405Not applicableResults posted
• Cognitive Fitness for Depression in Older AdultsCompletedNCT04790630Not applicableResults posted
• Trial to Evaluate the Effectiveness of a Digital Therapeutics in Adults Diagnosed With Major Depressive DisorderCompletedNCT04770285Not applicableResults posted
• Study of Efficacy and Safety of MIJ821 in Addition to Comprehensive Standard of Care on the Rapid Reduction of Symptoms of Major Depressive Disorder in Subjects Who Have Suicidal Ideation With IntentTerminatedNCT04722666Phase 2Results posted
• Phase 1 Evaluation of (2R,6R)-HydroxynorketamineCompletedNCT04711005Phase 1Results posted
• Antidepressant Response in Older Adults With Comorbid PTSD and MDDTerminatedNCT04697693Phase 4Results posted
• A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD)CompletedNCT04688164Phase 3Results posted
• Positive Processes and Transition to HealthCompletedNCT04678232Not applicableResults posted
• Open-Label Safety Study of AXS-05 in Subjects With TRD (EVOLVE)TerminatedNCT04634669Phase 2Results posted
• Electroconvulsive Therapy Amplitude TitrationCompletedNCT04621786Not applicableResults posted
• A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant and Long-term Safety Extension Treatment With SeltorexantCompletedNCT04533529Phase 3Results posted
• A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant TherapyTerminatedNCT04532749Phase 3Results posted
• In-person vs. Remote Wellness SupportCompletedNCT04526067Not applicableResults posted
• A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With DepressionCompletedNCT04521478Phase 2Results posted
• A Pilot Study of Creatine Monohydrate as an Augmenting Agent for ECT in Persons With Major Depressive DisorderCompletedNCT04504253Phase 3Results posted
• Social Reward and Its Effect on Brain Functions in Psychotherapies for Mid- and Late-Life DepressionCompletedNCT04487730Not applicableResults posted
• A Study of the Safety and Efficacy of SP-624 in the Treatment of Adults With Major Depressive DisorderCompletedNCT04479852Phase 2Results posted
• A Comparative Study of Sage-217 Plus an Antidepressant (ADT) Versus Placebo Plus an ADT in Adults With Major Depressive DisorderCompletedNCT04476030Phase 3Results posted
• Vagus Nerve Stimulation: Integration of Behavior and Cardiac ModulationCompletedNCT04467164Not applicableResults posted
• Impact of Transcutaneous Vagal Nerve Stimulation on Stress Response in Major DepressionCompletedNCT04448327Not applicableResults posted
• Non-interventional, Retrospective Cohort Study to Explore Antidepressant Treatment in KoreaCompletedNCT04446039Results posted
• A Study to Evaluate the Efficacy of Sage-217 in the Treatment of Adult Participants With Major Depressive Disorder (MDD)CompletedNCT04442490Phase 3Results posted
• eIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes RiskCompletedNCT04437485Phase 2Results posted
• A Home-based Study Using Mobile Technology to Test Whether BI 1358894 is Effective in People With DepressionTerminatedNCT04423757Phase 2Results posted
• 5-HTP and Creatine for DepressionCompletedNCT04395183Phase 2Results posted
• Transcranial Near Infrared Radiation and Cerebral Blood Flow in DepressionCompletedNCT04366258Not applicableResults posted
• Bupropion Versus Escitalopram on Reward Circuitry and Motivational DeficitsCompletedNCT04352101Phase 4Results posted
• A Study of MD-120 in Patients With DepressionCompletedNCT04345471Phase 3Results posted
• A Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release, Both in Combination With a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor, in Participants With Treatment Resistant Major Depressive DisorderCompletedNCT04338321Phase 3Results posted
• Study of Naltrexone-Induced Blockade of Antidepressant EffectsCompletedNCT04322526Phase 4Results posted
• Comparing Individual Therapies for Veterans With Depression, PTSD, and Panic DisorderCompletedNCT04293341Not applicableResults posted
• Clinical Trial Evaluating Lumateperone Monotherapy in the Treatment of Bipolar Depression or Major Depressive DisorderCompletedNCT04285515Phase 3Results posted
• Virtual Reality Behavioral Activation: An Intervention for Major Depressive DisorderCompletedNCT04268316Not applicableResults posted
• A Phase 2 Trial of OPC-64005 for Major Depressive DisorderCompletedNCT04244253Phase 2Results posted
• Improving Attentional and Cognitive Control in the Psychological Treatment of Intrusive ThoughtsCompletedNCT04225624Not applicableResults posted
• Study in Major Depressive Disorder With NMRA-335140 (BTRX-335140) vs PlaceboCompletedNCT04221230Phase 2Results posted
• Predicting SSRI Efficacy in Veterans With PTSDTerminatedNCT04183205Phase 4Results posted
• The BIomarker Guided (BIG) Study for DepressionCompletedNCT04181736Phase 4Results posted
• Closed-loop Optimized rTMS for DepressionCompletedNCT04142320Phase 1Results posted
• A Personalized Approach to Effects of Affective Bias Modification on Symptom Change and RuminationCompletedNCT04137367Not applicableResults posted
• Opiate Suicide Study in Patients With Major DepressionCompletedNCT04116528Phase 3Results posted
• A Study of CLE-100 (Oral Esketamine) in Addition to Standard Antidepressant Drug for Major Depressive Disorder - CLEO StudyCompletedNCT04103892Phase 2Results posted
• Ketamine Treatment Effects on Synaptic Plasticity in DepressionCompletedNCT04091971Phase 4Results posted
• A Study of JNJ-61393215 in the Treatment of DepressionCompletedNCT04080752Phase 2Results posted
• Maintenance Transcranial Magnetic Stimulation in Major Depressive DisorderCompletedNCT04076644Not applicableResults posted
• A Study to Evaluate the Efficacy and Safety of Fremanezumab for Preventive Treatment of Migraine in Patients With Major Depressive DisorderCompletedNCT04041284Phase 4Results posted
• Open-Label Safety Study of AXS-05 in Subjects With DepressionCompletedNCT04039022Phase 3Results posted
• A Trial of AXS-05 in Patients With Major Depressive DisorderCompletedNCT04019704Phase 3Results posted
• Mini Theta Burst TMS in MDD PatientsCompletedNCT04014959Not applicableResults posted
• A Study to Evaluate SAGE-217 for Prevention of Relapse in Adult Participants With Major Depressive DisorderTerminatedNCT04007367Phase 3Results posted
• Extension Study of Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepressant TreatmentTerminatedNCT04000009Phase 3Results posted
• Mechanism of Action of tACS for the Treatment of MDDCompletedNCT03994081Not applicableResults posted
• Comparing Group Therapies for Veterans With Depression and PTSDCompletedNCT03979040Not applicableResults posted
• Adjunctive Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepressant TreatmentCompletedNCT03968159Phase 3Results posted
• Investigation of Genetic Predictors of the Response to Selective Serotonin Re-uptake Inhibitors (SSRI) TreatmentCompletedNCT03927950Phase 4Results posted
• Primary-Care Based Mindfulness InterventionCompletedNCT03922581Not applicableResults posted
• Ketamine for Severe Adolescent Depression: Intermediate-term Safety and EfficacyTerminatedNCT03889756Phase 2/3Results posted
• A Study of Psilocybin for Major Depressive Disorder (MDD)CompletedNCT03866174Phase 2Results posted
• A Study to Evaluate SAGE-217 in Adult Participants With Major Depressive Disorder (MDD)CompletedNCT03864614Phase 3Results posted
• Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac SurgeryCompletedNCT03861988Phase 4Results posted
• A Study in People With Depression to Test the Effects of BI 1358894 on Parts of the Brain That Are Involved in EmotionsCompletedNCT03854578Phase 1Results posted
• Treating Smokers With Mental IllnessCompletedNCT03822416Phase 2Results posted
• Contact: Developing New Clinical Management StrategiesCompletedNCT03812588Phase 4Results posted
• A Study to Evaluate the Safety, Tolerability, and Efficacy of SAGE-217 Compared to Placebo in Adult Participants With Comorbid Major Depressive Disorder (MDD) and InsomniaTerminatedNCT03771664Phase 3Results posted
• L-DOPA vs. Placebo for Depression and Psychomotor Slowing in Older AdultsTerminatedNCT03761030Phase 4Results posted
• The Objective of This Study is to Evaluate the Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) Who Have Had an Inadequate Response to Antidepressants AloneCompletedNCT03739203Phase 3Results posted
• Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) Who Have Had an Inadequate Response to Antidepressants AloneCompletedNCT03738215Phase 3Results posted
• A Long-Term Study of Brexpiprazole in Patients With Major Depressive DisorderCompletedNCT03737474Phase 3Results posted
• Zelquistinel in the Treatment of Adults With Major Depressive DisorderCompletedNCT03726658Phase 1/2Results posted
• Universal vs. Targeted School Screening for Adolescent Major Depressive DisorderCompletedNCT03716869Not applicableResults posted
• A Study of Brexpiprazole in Patients With Major Depressive DisorderCompletedNCT03697603Phase 2/3Results posted
• A Study to Evaluate SAGE-217 in Participants With Bipolar I/II Disorder With a Current Major Depressive EpisodeCompletedNCT03692910Phase 2Results posted
• Reward Function and Therapy for Late-Life DepressionCompletedNCT03688139Not applicableResults posted
• Study of Rapastinel as Monotherapy in Patients With Major Depressive Disorder (MDD)TerminatedNCT03675776Phase 3Results posted
• A Study to Evaluate the Efficacy of SAGE-217 in the Treatment of Adult Participants With Major Depressive DisorderCompletedNCT03672175Phase 3Results posted
• Study of Adjunctive or Monotherapy Rapastinel Treatment in Patients With Major Depressive Disorder (MDD)TerminatedNCT03668600Phase 3Results posted
• Development of Pregnenolone as a Treatment for DepressionCompletedNCT03645096Phase 1Results posted
• A Trial to Measure the Difference in All-cause Hospitalizations for Participants Who Are Using Abilify MyCite Versus Virtual Matched Controls in Adults With Schizophrenia, Bipolar 1 Disorder, and Major Depressive DisorderTerminatedNCT03643159Phase 4Results posted

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