Depressive Disorder, Major: all 2,805 studies

Page 6 of 29. Open to participants first (565), then studies with results posted, then the rest; newest registration first within each.

• Temporal Interference and DepressionRecruitingNCT05295888Not applicable
• Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological ManipulationRecruitingNCT05232032Phase 2
• The Pill Project - Oral Contraceptive and Serotonergic Brain SignalingRecruitingNCT05212389Not applicable
• Effectiveness of an Integrated Care Pathway for Depression: Cluster Randomized Controlled TrialRecruitingNCT05142683Not applicable
• NMDA Modulation in Antidepressant Nonresponders With Major Depressive DisorderRecruitingNCT05136755Phase 2
• The Neurobiological Fundaments of Depression and Its Relief Through Neurostimulation TreatmentsRecruitingNCT05135897
• Testing a Precision Psychotherapy System for Low-income PatientsNot yet recruitingNCT05118594Not applicable
• RCT of At-Home tDCS for Depression in PregnancyRecruitingNCT05097586Not applicable
• Aerobic Versus Leisure Group for Adolescents With DepressionRecruitingNCT05076214Not applicable
• Exercise Training for Managing Major Depressive Disorder in Multiple SclerosisRecruitingNCT05051618Not applicable
• Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)RecruitingNCT05017311Phase 4
• MRI Markers of Feedback Timing During Learning in Individuals with TBI with and Without Clinical DepressionRecruitingNCT05009511Not applicable
• Gut Microbiota in Major Depressive Disorders With and Without Rapid Eye Movement Behavior DisorderRecruitingNCT05008120
• Aβ Dynamics in LLMDRecruitingNCT05004987Phase 4
• Left vs. Right Non-Inferiority TrialRecruitingNCT04999553Not applicable
• The Efficacy And Safety Of Mitizodone Phosphate Tablets In The Treatment of Patient With Major Depressive DisorderRecruitingNCT04984512Phase 2/3
• Safety of Liposom With Citalopram in Elderly Patients With Major Depressive DisorderRecruitingNCT04975724Phase 4
• rTMS for Depression in Young Adults With AutismRecruitingNCT04972136Not applicable
• Remotely Non-invasive Brain Stimulation and Videogame to Alleviate DepressionRecruitingNCT04953208Not applicable
• Extended Effects of Cannabis Abstinence on Clinical Symptoms and Cognition in DepressionRecruitingNCT04935619Not applicable
• MicroRNA Correlates of Childhood Maltreatment and SuicidalityRecruitingNCT04923685
• Treatment of Acute Mood Depressive Episode in Borderline Personality Disorder With rTMSRecruitingNCT04870255Not applicable
• Sumor as Adjuvant Therapy in Treatment-resistant Major DepressionRecruitingNCT04832178Phase 4
• The Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Major Depressive DisorderRecruitingNCT04805879Phase 2/3
• Neural Correlates of Stress and Perceived Control in Adolescent DepressionRecruitingNCT04788524Not applicable
• Neural Response to Inflammatory Challenge in Major Depressive DisorderRecruitingNCT04751331Phase 1/2
• Maternal Mental Health TrialRecruitingNCT04685148Phase 1/2
• NMDA Modulation in Major Depressive DisorderRecruitingNCT04637620Phase 2
• Imaging Neural Correlates of Ketamine Using PET/MRRecruitingNCT04587778Phase 1
• Biomarkers of Depression and Treatment ResponseRecruitingNCT04581902Not applicable
• Supportive-Expressive and Emotion-Focused Treatment for DepressionRecruitingNCT04576182Not applicable
• Pain and Major Depressive DisorderRecruitingNCT04556890Not applicable
• Model-based Defining of Subtypes of Depression and Optimal Treatment: an Integrated Techniques Module.RecruitingNCT04518592
• Psychostimulant Augmentation of Repetitive TMS for the Treatment of Major Depressive DisorderEnrolling by invitationNCT04509102Early Phase 1
• University of Iowa Interventional Psychiatry Service Patient RegistryRecruitingNCT04480918
• Accelerated iTBS for Depression and SuicidalityNot yet recruitingNCT04441008Not applicable
• Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric PopulationsRecruitingNCT04296604Not applicable
• Brain Imaging of Cognition Inn Schizophrenia and DepressionRecruitingNCT04159662
• Comparing Uni- and Bi-lateral TBS in Major DepressionRecruitingNCT04142996Not applicable
• Augmentation of EMDR With tDCS in the Treatment of FibromyalgiaRecruitingNCT04084795Not applicable
• Near Infrared Spectroscopy (NIRS) for Assessment of DepressionRecruitingNCT04061148Not applicable
• Optimal Electrical Stimulus During Electroconvulsive TherapyRecruitingNCT04057378Phase 4
• Biomarker-guided rTMS for Treatment Resistant DepressionRecruitingNCT04041479Phase 3
• Spectral TMS (s-TMS)Enrolling by invitationNCT04040062Not applicable
• Closed-Loop Deep Brain Stimulation for Major DepressionRecruitingNCT04004169Not applicable
• Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major DepressionRecruitingNCT03973268Phase 1
• Pharmacogenetics of Antidepressant-Induced DisinhibitionRecruitingNCT03953014
• Brain Insulin Resistance in Mood DisordersRecruitingNCT03915613Phase 1/2
• Mechanisms of Rumination Change in Adolescent DepressionRecruitingNCT03859297Not applicable
• A Phase I/II Study of PDC-1421 for Treating Depression in Cancer PatientsNot yet recruitingNCT03833206Phase 1/2
• Nitrous Oxide- Suicidal IdeationEnrolling by invitationNCT03736538Phase 1
• Group Metacognitive Therapy vs Clinical Management for DepressionRecruitingNCT03711123Not applicable
• Deep TMS for Comorbid Depression and Cognitive Impairment in Older AdultsRecruitingNCT03665831Not applicable
• Genetic Counselling in the Prevention of Mental Health Consequences of Cannabis UseRecruitingNCT03601026Not applicable
• Characterizing Synaptic Density in Treatment Resistant DepressionRecruitingNCT03537794
• Characterization and Treatment of Adolescent DepressionRecruitingNCT03388606
• Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive DisorderRecruitingNCT03065335Phase 1
• NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain CircuitsRecruitingNCT02994433Phase 1
• Personalized Indications for CBT and Antidepressants in Treating DepressionRecruitingNCT02752542Phase 4
• Neurobiology of SuicideRecruitingNCT02543983Phase 2
• Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression ProjectRecruitingNCT02434393
• Efficacy and Safety of Bupropion Hydrobromide in Adolescents and Children With Major Depressive DisorderNot yet recruitingNCT02129751Phase 4
• Ketamine Alcohol (in Treatment-Resistant Depression)RecruitingNCT02122562Phase 2
• Psychiatric Genotype/Phenotype Project RepositoryEnrolling by invitationNCT00762866
• Study of Neuro-Cognitive Correlates of Pediatric Anxiety DisordersRecruitingNCT00018057Phase 2
• Pilot Study of Personalized Aperiodic Transcranial Alternating Current Stimulation in Antenatal Depression (PandA-tACS)TerminatedNCT06979154Not applicableResults posted
• Preventing Relapse After Successful Electroconvulsive Therapy for DepressionCompletedNCT06751875Not applicableResults posted
• A Study of Aticaprant Plus an Antidepressant to Prevent Return of Depression Symptoms in Participants With Major Depressive Disorder Who Experience a Loss of Interest and PleasureTerminatedNCT06635135Phase 3Results posted
• A Study to Test Different Doses of BI 1569912 in People With DepressionCompletedNCT06558344Phase 2Results posted
• Daily Stress and Vascular Function in Midlife as a Risk Factor for Cognitive DeclineCompletedNCT06466655Not applicableResults posted
• A Trial to Assess a Wearable Patch's Functioning to Detect Medication IngestionCompletedNCT06372210Not applicableResults posted
• A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major Depressive DisorderCompletedNCT06340958Phase 2Results posted
• A Clinical Study to Evaluate of Single and Multiple Oral Doses of GM-1020 in Patients With MDDCompletedNCT06309277Phase 2Results posted
• A Study to Test Different Doses of BI 1569912 in People With Depression Who Take Anti-depressive MedicineCompletedNCT06280235Phase 2Results posted
• Open-Label of SPN-820 in Adults With Major Depressive DisorderCompletedNCT06235905Phase 2Results posted
• Modulating Repetitive Negative Thinking Related Brain Networks in Young Adults With DepressionTerminatedNCT06219681Not applicableResults posted
• Study Evaluating Safety and Efficacy of Ropanicant in MDD PatientsCompletedNCT06126497Phase 2Results posted
• Randomized, Double-Blind, Placebo-Controlled Trial of REL-1017 as Adjunctive Treatment for MDDTerminatedNCT06011577Phase 3Results posted
• CBT+ for DepressionCompletedNCT06001346Not applicableResults posted
• iCBT With TMS in Patients With MDDCompletedNCT05988619Not applicableResults posted
• A Database Survey of Comparison The Risk of Haemorrhage Between Vortioxetine Tablet Treatment and Selective Serotonin Reuptake Inhibitor (SSRI) Treatment in Participants With DepressionCompletedNCT05932407Results posted
• Study of the Effectiveness of Valbenazine on Patient- and Clinician-Reported Outcomes in Participants With Tardive DyskinesiaCompletedNCT05859698Phase 4Results posted
• Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of DepressionCompletedNCT05772702Not applicableResults posted
• HypErthermia as an Additional Treatment for the Biology and Experience of Depression: Study 2CompletedNCT05708976Not applicableResults posted
• Augmenting Single-session Behavioral Activation (BA) With Delta-beta Transcranial Alternating Current Stimulation (tACS) for the Treatment of DepressionCompletedNCT05693922Not applicableResults posted
• Study to Evaluate TNX-601 ER Monotherapy Versus Placebo in Patients With Major Depressive Disorder (MDD)CompletedNCT05686408Phase 2Results posted
• Individualized Functional Connectivity Targeting in aiTBS for DepressionCompletedNCT05680727Phase 2Results posted
• A Study of Aticaprant 10 Milligrams (mg) as Adjunctive Therapy in Adult Participants With MDD With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant TherapyCompletedNCT05550532Phase 3Results posted
• Study to Evaluate Treatment Effects Associated With the NeuroStar SoftStart Treatment FeatureCompletedNCT05535062Not applicableResults posted
• A Study of Aticaprant in Adult and Elderly Participants With Major Depressive Disorder (MDD)TerminatedNCT05518149Phase 3Results posted
• A Study of Aticaprant as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant TherapyCompletedNCT05455684Phase 3Results posted
• ANC-501 in the Treatment of Adults With Major Depressive DisorderCompletedNCT05439603Phase 2Results posted
• The Effects of Videogames on Depression Symptoms and Brain DynamicsCompletedNCT05426265Not applicableResults posted
• Therapist-Guided Smartphone-Delivered CBT for MDDCompletedNCT05386329Not applicableResults posted
• Cranial Electrotherapy Stimulation for the Treatment of Major Depressive Disorder in AdultsCompletedNCT05384041Not applicableResults posted
• A Study to Evaluate the Safety, Tolerability and Efficacy of XEN1101 in Major Depressive DisorderCompletedNCT05376150Phase 2Results posted
• Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily RhythmsCompletedNCT05317481Not applicableResults posted
• Psilocybin-assisted CBT for DepressionCompletedNCT05227612Phase 1Results posted
• Probing the Dorsolateral Prefrontal Cortex and Central Executive Network for Improving Neuromodulation in DepressionCompletedNCT05224063Not applicableResults posted
• Empower: tDCS for Major Depressive Disorder at HomeCompletedNCT05202119Not applicableResults posted

← Depressive Disorder, Major overview