An interventional study of Supportive-expressive treatment and Emotions-Focused treatment in Major Depressive Disorder, sponsored by University of Haifa. Recruiting at 1 site in Israel. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-05-07.
Sponsored by University of Haifa · Not applicable, Interventional, and Treatment
This study will explore the mechanisms of change that are activated when individuals receive a treatment that targets their weakness and the mechanisms activated when the treatment capitalize on their strength. Patients will be assigned to one of two types of psychotherapies in treating people with a major depression disorder, expressive-supportive vs. emotion-focused treatment. Their ability to benefit from treatment based on their pre-treatment levels of insight and emotional processing will be examined. This is a four-month protocol, with a 2 year follow up period.
One hundred and twenty-four patients suffering from major depressive disorder will be randomized to participate in 16 sessions of either supportive-expressive therapy or emotion-focused therapy. The two treatments are theorized to differ in their main mechanism of change: supportive-expressive therapy places emphasis on insight as its main mechanism of change, and emotion-focused therapy places emphasis on emotional processing as its main mechanism of change. Both can serve as strength- or weakness-focused treatments, based on the patient's baseline levels of insight and emotional processing. Importantly, this study will employ multiple complementary methods, which will include session-by-session self-report questionnaires from both patient and therapist, as well as interdisciplinary measures based on hormonal and acoustic measures, cognitive tasks, clinician interviews, and behavioral coding systems to complement the self-report measures. In addition, prior the beginning of treatment patients will complete diaries via mobile survey application. The findings will contribute to the research on personalized mechanisms of change and can help clinicians focus on more efficient treatment delivery, adapted to given subpopulations of patients, according to their strengths and weaknesses. If a mechanism most likely to stimulate change for a subpopulation is identified, a corresponding treatment can be chosen that is most likely to activate that particular mechanism and by that improve the rate of patients' respondent to treatment.
2,740 studies on the registry are indexed under Depressive Disorder, Major; 558 are open to participants now.
This study's planned enrollment of 124 is above the median of 80 across 2,282 interventional studies indexed under Depressive Disorder, Major.
Browse Depressive Disorder, Major studies →University of Haifa is the lead sponsor of 101 studies on the registry; 25 are open to participants now.
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Exclusion Criteria:
Participants will receive supportive-expressive treatment for 16 weeks.
Behavioral: Supportive-expressive treatment
Participants will receive Emotion-Focused treatment for 16 weeks.
Behavioral: Emotions-Focused treatment
Sixteen weeks of a time-limited psychodynamic therapy adapted for depression that includes the use of expressive techniques, such as interpretation, confrontation, clarification and the use of supportive techniques, such as affirmation and empathic validation. This treatment postulates insight as its core mechanism of change.
Sixteen weeks of a brief experiential therapy for depression that combine client-centered relational elements (unconditional positive regard, congruence, and empathy) with marker-guided experiential interventions designed to facilitate and deepen emotional processing and emotion regulation.
Weekly change in Hamilton rating scale for depression (HRSD)
A 17-item clinically administered measure assessing the severity of depression. Higher scores indicate worse outcome.
Time frame: up to 16 weeks.
Weekly change in Beck Depression Inventory (BDI)
A 21-item, self-rated scale that evaluates key symptoms of depression. Higher scores indicate worse outcome.
Time frame: up to 16 weeks
Weekly change in Outcome Questionnaire (OQ)
A 30 items self-report measure designed to assess patient therapy outcomes on three primary dimensions: (a) subjective discomfort, (b) interpersonal relationships, and (c) social role performance. Higher scores indicate worse outcome.
Time frame: up to 16 weeks
Trajectories of change in Inventory of Interpersonal Problems (IIP-32)
A 32-item self-report measure designed to assess interpersonal problems. Each item is rated in terms of how distressing the problem is for the individual on a scale ranging from 0 (not at all) to 4 (extremely). Higher scores indicate worse outcome.
Time frame: At intake and 6 times during the treatment (weeks 1, 2, 4, 8, 12, 16)
trajectories of change in Quality of Life Enjoyment and Satisfaction- Short Version (Q-LES-Q)
Quality of Life Enjoyment and Satisfaction Scale. Higher scores indicate better outcome.
Time frame: At intake and 6 times during the treatment (weeks 1, 2, 4, 8, 12, 16)
Plan to share: No — Data will not be shared due to ethical reasons.
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University of Haifa