Dengue clinical trials
The registry lists 283 studies for Dengue across more than 10 countries. 44 are recruiting or about to start. 215 of them are mainly about Dengue (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Severe Dengue too: 290 studies, 47 open.
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Status
Who runs them
National Institute of Allergy and Infectious Diseases (NIAID) (35) · Sanofi Pasteur, a Sanofi Company (30) · Takeda (17) · U.S. Army Medical Research and Development Command (16) · Sanofi (6) · Butantan Institute (6) · Mahidol University (6) · Oxford University Clinical Research Unit, Vietnam (5)
What is being tested here
Drugs under test in Dengue studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jan 2027A Study of CP-COV03 Compared With Placebo in Participants With Dengue (Part 1) and Dengue-like Illness (Part 2) · Phase 3 · Hyundai Bioscience Co., Ltd.
- Jan 2027Efficacy of Montelukast in Preventing Transaminase Elevation in Adult Dengue Patients · Phase 3 · Phramongkutklao College of Medicine and Hospital
- Mar 2027Butantan-DV Vaccine in Elderly Populations (DEN-04-IB) · Phase 3 · Butantan Institute
- Apr 2027A Study of Dengue Tetravalent Vaccine (TDV) in Adults (Age 45 to 60 and >60 to 79 Years) · Phase 3 · Takeda
- Jul 2027Trial to Evaluate the Immunogenicity and Safety of the Co-administration of Live Attenuated Dengue and Chikungunya Vaccines Compared to Separate Administration in Adults Aged 18 to 59 Years. · Phase 3 · Butantan Institute
- Dec 2026Bridging Economics and Public Trust: A Study of Dengue Vaccine Cost-effectiveness and Acceptance in Thais Visiting Hospital · Mahidol University
- Dec 2026Improving Disease Prevention Strategies by Integrating Socio-spatial Characterization of Human Mobility · Institute of Tropical Medicine, Belgium
- Jan 2027Gut Leakage' in Dengue · University of Oxford
- May 2027A Study to Monitor the Adverse Events of QDENGA Vaccine in Participants in Malaysia · Takeda
- Jun 2027Clinical Trial Evaluating Safety and Efficacy of Resomelagon on Dengue Infection (RESOVIR-2) · Federal University of Minas Gerais
Who these studies take
Of the 27 Dengue studies recruiting now, 16 (59%) set no upper age limit and 11 (41%) stop at 75 or younger. 16 (59%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 9 (33%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 15 (56%) | 15 (56%) |
| 18 | 23 (85%) | 23 (85%) |
| 30 | 23 (85%) | 23 (85%) |
| 40 | 23 (85%) | 23 (85%) |
| 50 | 23 (85%) | 23 (85%) |
| 65 | 21 (78%) | 21 (78%) |
| 75 | 17 (63%) | 17 (63%) |
| 85 | 16 (59%) | 16 (59%) |
Across all 283 studies, recruiting or not: 65% stop at 75 or younger and 62% at 65; 47% take children; 2% are for women only and 1% for men only; 67% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Dengue studies take
Of 31 phase 2 interventional studies under Dengue, half reached primary completion within 20 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 14 mo8–18 · 22 studies | — | — |
| Phase 2 | 20 mo14–38 · 31 studies | 21 mo14–47 · 21 studies | — |
| Phase 3 | 24 mo7–30 · 21 studies | — | — |
| Interventional, no phase | 12 mo6–36 · 30 studies | — | 12 mo5–27 · 25 studies |
| Observational | 47 mo31–71 · 36 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 283. Browse all 283 → or search them.
- A Study to Assess the Efficacy, Safety and Pharmacokinetics of EYU688 in Patients With Dengue FeverRecruitingNCT06006559Phase 27 countries
- Phase 1 Challenge Study Using rDEN2delta30-7169 to Evaluate Host-Pathogen Interactions in Primary, Homotypic, and Heterotypic Dengue Virus InfectionRecruitingNCT07706686Phase 11 country
- Emetine for Viral Outbreaks (a.k.a. EVOLVE Antiviral Initiative)RecruitingNCT07016321Phase 2/32 countries
- Adaptive Dengue Antiviral Platform TrialRecruitingNCT06551844Phase 22 countries
- Immune Responses to Dengue and SepsisRecruitingNCT070402021 country
- Phase I Study of VLPDEN-02 Dengue Vaccine in Healthy AdultsNot yet recruitingNCT07831473Phase 11 country
- Clinical Trial Evaluating Safety and Efficacy of Resomelagon on Dengue Infection (RESOVIR-2)RecruitingNCT06917001Phase 21 country
- Investigating and Modelling the Natural History of Dengue in Hospitalised Patients to Improve Future ResearchNot yet recruitingNCT077991681 country
- Smart Analysis and Decision-Making for Emerging Infectious DiseasesEnrolling by invitationNCT07678619Not applicable1 country
- Gut Leakage' in DengueRecruitingNCT076029201 country
- Zanamivir Treatment of Vascular Permeability in Dengue (ZAP-DENGUE)RecruitingNCT04597437Phase 21 country
- Phase 3b Trial To Evaluate Safety And Immune Response (Superiority) of a Two-Dose Butantan-DV Regimen And The Standard Single Dose In Dengue-Naive Children/Adolescents and Immune Response (Non-inferiority) in a Manufacturing Facility Change (DEN-06-IB)Not yet recruitingNCT07712926Phase 3
- Trial to Evaluate the Immunogenicity and Safety of the Co-administration of Live Attenuated Dengue and Chikungunya Vaccines Compared to Separate Administration in Adults Aged 18 to 59 Years.Not yet recruitingNCT06973772Phase 31 country
- A Study of CP-COV03 Compared With Placebo in Participants With Dengue (Part 1) and Dengue-like Illness (Part 2)RecruitingNCT07576868Phase 2/31 country
- Metabolic and Infectious Diseases in La Réunion (the REUNION Population-based Study)RecruitingNCT054008241 country
- A Study of 2 Doses of Tetravalent Dengue Vaccine (TDV) in Infants and ToddlersRecruitingNCT06665035Phase 32 countries
- Effects Of A Rehabilitation Protocol On Muscle Strength, Muscle Fatigue And Postural Control In Post-Dengue And Chikungunya PatientsNot yet recruitingNCT07600879Not applicable1 country
- Therapeutics for Moderate and Severe DengueNot yet recruitingNCT07543458Phase 310 countries
- A Study in Children and Teenagers to Learn if a TDV Dengue Vaccination Lowers the Chance of Hospital Stays for DengueRecruitingNCT068432263 countries
- Xpert® Tropical Fever Test on GeneXpert® Edge X SystemEnrolling by invitationNCT075202791 country
- International Registry of Dengue Infection in Congenital Bleeding Disorders (DengueCBDR)RecruitingNCT074098571 country
- Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health PerspectiveRecruitingNCT073589101 country
- Dengvaxia US Pregnancy RegistryRecruitingNCT044866381 country
- Dengue - Sample Collection Study PakistanNot yet recruitingNCT07203183
- Risk Factors for Hospitalization and Transfusion Criteria in Patients With Dengue Virus InfectionRecruitingNCT070075851 country
- To Assess the Efficacy of Carica Papaya Leaf Extract in Improving Platelet Counts Among Pediatric Patients With Dengue-associated ThrombocytopeniaEnrolling by invitationNCT07172100Phase 21 country
- Prospective Clinical Registry for Evaluation of Exanthematous Infections and CoinfectionsNot yet recruitingNCT07112846
- Molecular and Cellular Basis of Severe Forms of Dengue in Sickle Cell PatientsRecruitingNCT070007471 country
- Effectiveness Evaluation of the "Mosquito-Free Campus" Initiative on Dengue Fever Prevention and Control: A Cluster Randomized Controlled TrialNot yet recruitingNCT07002021Not applicable
- Efficacy of Montelukast in Preventing Transaminase Elevation in Adult Dengue PatientsRecruitingNCT06747130Phase 2/31 country
- Characterisation of Dengue Vaccine-induced Specific Immunity in Vaccinees With and Without Prior Exposure to Flavivirus Infections or VaccinationRecruitingNCT067766921 country
- Safety, Virological and Immunological Assessment of the Controlled Dengue Human Infection Model in Dengue-Immune Participants in Thailand (DHIT-Immune)Not yet recruitingNCT06908018Early Phase 1
- Impact of IIT-SIT on Dengue ClustersRecruitingNCT06894901Not applicable1 country
- Dengue Vaccine Strategy in Children Aged 9 to 17 Years in the French CaribbeanRecruitingNCT048397571 country
- Genetic Determinants of the Antiviral Immune Response in Oceanian PopulationsNot yet recruitingNCT06432855Not applicable1 country
- Virological and Immunological Determinants of Arbovirus Infection in New CaledoniaRecruitingNCT04619823Not applicable1 country
- Genetic Evolution of Arboviruses in New Caledonia Between 1995 and 2024 and Impact of WolbachiaRecruitingNCT046153641 country
- Dengue Virus Infection Amongst Patients With Acute Febrile IllnessRecruitingNCT062555091 country
- Prevalence of Hyponatremia in Dengue Infected Patients: Relationship With Systemic Inflammation.RecruitingNCT061095321 country
- Role of Vitamin D in Prevention of Dengue Haemorrhagic Fever and Dengue Shock SyndromeRecruitingNCT06071481Phase 21 country
- A Dengue Sero-prevalence Study in the Metropolitan Area of Buenos AiresRecruitingNCT059192771 country
- Study of Dengue in Patients With Autoimmune Diseases During the Epidemics of 2020 and 2021 in Reunion IslandNot yet recruitingNCT05852977
- Safety, Virological and Immunological Assessment of Live Attenuated Dengue Serotype 2 rDEN2delta30-7169.Not yet recruitingNCT05476757Early Phase 11 country
- Infection Tracking in Travellers. The Project Aims to Identify Profiles of Travel-associated Illness and to Follow up on Long-term Sequelae of Arboviral Infections and MalariaNot yet recruitingNCT046725771 country
- Butantan-DV Vaccine in Elderly Populations (DEN-04-IB)Active, not recruitingNCT06891950Phase 31 country
- An Evaluation of Repeated Oral Doses of JNJ-64281802 Against DENV-3 ChallengeCompletedNCT05048875Phase 21 country
- Investigating Vector-Borne Determinants of Aedes Transmitted Arboviral Infections in Cambodia: An Observational Longitudinal Cohort Study in ChildrenCompletedNCT035342451 country
- A Controlled Human Infection Model of DengueActive, not recruitingNCT07412483Not applicable1 country
- Immunogenicity of an Intradermal Qdenga Vaccine Among Healthy VolunteersCompletedNCT06837116Early Phase 11 country
- Efficacy and Safety of Indoor Residual Spray for Dengue Vector ControlCompletedNCT07838701Not applicable1 country