An observational study in Dengue Fever, sponsored by Mahidol University. Active, not recruiting at 1 site in Thailand. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-17.
Sponsored by Mahidol University · Observational
Study 1: Cost-effectiveness of TAK-003 Dengue Vaccination in Thailand
This study aims to evaluate the cost-effectiveness of introducing the live-attenuated tetravalent dengue vaccine (TAK-003) into Thailand's national immunization program. The study will compare routine vaccination strategies targeting two high-risk age groups: older children aged 9-14 years and adolescents/young adults aged 15-24 years, to identify the most appropriate target population for national implementation.
A model-based economic evaluation will be conducted using a static Markov model combined with a decision tree from a societal perspective. Model parameters will be obtained from published literature, national surveillance databases, healthcare utilization data, and other relevant sources. The model will estimate lifetime health outcomes, healthcare costs, quality-adjusted life years (QALYs), incremental cost-effectiveness ratios (ICERs), and budget impact. Deterministic and probabilistic sensitivity analyses will be performed to assess uncertainty in model parameters.
The findings are expected to provide evidence to support policy decisions regarding the inclusion of TAK-003 in Thailand's national immunization program.
Study 2: Determinants of Dengue Vaccine Acceptance among Thai Adults and Parents
This study aims to examine dengue vaccine acceptance and factors influencing vaccination decisions among Thai adults and parents of children aged 4-18 years. Understanding vaccine acceptance is essential for successful implementation of future dengue vaccination programs in Thailand.
This study will employ a sequential explanatory mixed-methods design consisting of two phases. The first phase is a cross-sectional survey conducted among Thai adults and parents attending outpatient clinics at two tertiary hospitals. Participants will complete a structured questionnaire assessing sociodemographic characteristics, dengue-related experiences, psychological antecedents of vaccination using a modified Thai version of the 7Cs model, willingness to pay, and dengue vaccine acceptance.
In the second phase, purposively selected participants from the quantitative survey will participate in semi-structured in-depth interviews to explore perceptions, beliefs, attitudes, and contextual factors influencing dengue vaccine decision-making. Quantitative and qualitative findings will be integrated to provide a comprehensive understanding of vaccine acceptance and hesitancy.
The findings will provide evidence to inform communication strategies, public health interventions, and policy development aimed at improving dengue vaccine uptake in Thailand.
283 studies on the registry are indexed under Dengue; 44 are open to participants now.
This study's planned enrollment of 350 is below the median of 595 across 80 observational studies indexed under Dengue.
Browse Dengue studies →Mahidol University is the lead sponsor of 747 studies on the registry; 119 are open to participants now.
Counted across the registry records on this site, refreshed daily.
General population Inclusion criteria - Visiting hospitals for routine follow up their medical conditions at Med OPD, Hospital for Tropical Diseases Mahidol University.
Parents Inclusion criteria
- Visiting hospitals for their children's routine follow up appointment at children OPD Siriraj Hospital, Mahidol University
General population
Inclusion criteria
Exclusion criteria
Parents
Inclusion criteria
Exclusion criteria
Children age 9-14 and 15-24 years without dengue vaccine
Other: Objective 1- economic evaluation of Thai children with dengue vaccine
Thai children age 9-14 and 15-24 years with dengue vaccine
Dengue vaccine hesitancy measured using the 7C-model
Dengue vaccine hesitancy will be assessed using an adapted version of the validated 7C Model of Vaccine Readiness questionnaire. The questionnaire will be adapted to the context of dengue vaccination while retaining the seven psychological antecedents of vaccination: Confidence, Complacency, Constraints, Calculation, Collective Responsibility, Compliance, and Conspiracy. Scoring of the 7C model: Each item was rated on a 7-point Likert scale from 1 to 7. For each 7C domain, the mean score of its constituent items was calculated, resulting in a domain score ranging from 1 to 7. A higher score indicated greater vaccine hesitancy. Items were reverse-scored where necessary so that the direction of all domain scores was consistent, with higher scores representing greater vaccine hesitancy.
Time frame: 1 year
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: Undecided
Started Feb 2026 (actual). Primary completion is estimated for Dec 2026, 9 months after the start.
Of 36 observational studies under Dengue, half reached primary completion within 47 months of starting (the median), counting those still running; a quarter within 31 and three quarters within 71. This study's planned 9 months is below that.
How these figures are worked out, and which studies are left out of them.
This study is active, not recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.