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TerminatedNCT00406744Updated Jun 3, 2024

Efficacy of Retreatments With Intravitreal Bevacizumab

A Phase 3 interventional study of Intravitreal injection of Bevacizumab in Age Related Macular Degeneration and Choroidal Neovascularization, sponsored by Asociación para Evitar la Ceguera en México. Terminated at 1 site in Mexico. Open to participants aged 60 Years to 95 Years. Per ClinicalTrials.gov, last updated 2024-06-03.

Sponsored by Asociación para Evitar la Ceguera en México · Phase 3, Interventional, and Treatment

Why this study was terminated
Poor accrual

From the registry’s dates

  • Registered 6 months after the study started (first participant enrolled May 2006, registered Nov 2006).
Phase
Phase 3
Study type
Interventional
Enrollment
20
Allocation
Randomized
Ages
60 Years to 95 Years
Sex
All
01

Study summary

Choroidal neovascularization is a leading cause of visual loss in people older than 60 years and for its treatment there had been performed multicentric studies with Lucentis (Ranibizumab) with a significant improval of visual acuity. In our institution we evaluated efficacy of bevacizumab in several pathologies but we dont know what would be the results if we use the same dose several times. Our purpose was to determine the efficacy of bevacizumab for improve or stabilize visual acuity with two or more intravitreal inyections of bevacizumab.

02

Conditions studied

  • Age Related Macular Degeneration
  • Choroidal Neovascularization

Keywords

  • neovascularization
03

In context

Macular Degeneration

1,459 studies on the registry are indexed under Macular Degeneration; 238 are open to participants now.

This study's enrollment of 20 is below the median of 56 across 985 interventional studies indexed under Macular Degeneration.

Browse Macular Degeneration studies →

Lead sponsor

Asociación para Evitar la Ceguera en México is the lead sponsor of 60 studies on the registry; 6 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
60 Years to 95 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • * Any visual acuity

    • OCT: Central foveal thickness greater than 300 u or with evidence of subretinal fluid.
    • Active angiogram leakage

Exclusion criteria

Exclusion Criteria:

  • * Basal Inflammatory disease

    • Endoftalmitis history
    • Lesions bigger than 5400 u or with scarring greater than 50% of lesion.
05

Study design

Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
20 participants (actual)
06

What researchers measure

Primary outcomes

  1. Best corrected visual acuity, OCT foveal thickness and fluorescein angiogram

07

Study locations

1 site
  • Asociacion para Evitar la Ceguera en Mexico
    Mexico DF, DF 04030, Mexico
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 3, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00406744
Lead sponsor
Asociación para Evitar la Ceguera en México
First posted
Dec 4, 2006
Start date
May 2006
Primary completion
May 2006
Completion
Nov 2006
Last update
Jun 3, 2024

Study contacts

Veronica Kon-Jara, MD
principal investigator · Asociación para Evitar la Ceguera en México
View the source record on ClinicalTrials.gov ↗

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This study is terminated, as verified in May 2024. You cannot join it, but the record below documents what was studied.

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