Carcinoma, Squamous Cell clinical trials
The registry lists 627 studies for Carcinoma, Squamous Cell across more than 10 countries. 133 are recruiting or about to start. 181 of them are mainly about Carcinoma, Squamous Cell (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 2 narrower conditions too, such as Squamous Cell Carcinoma of Head and Neck: 3,115 studies, 903 open.
ClinicalTrials.gov finds 5,000 studies for Carcinoma, Squamous Cell. How that becomes 627 here
This page counts the studies the registry files under Carcinoma, Squamous Cell, and those it files under no condition that list Carcinoma, Squamous Cellthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 5,000Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −2,484Filed under a narrower condition, counted on its own pageSquamous Cell Carcinoma of Head and Neck 1,807 · Esophageal Squamous Cell Carcinoma 568
- −500List Carcinoma, Squamous Cell as a condition, but the registry did not file them under itMost often written as “Cutaneous Squamous Cell Carcinoma” (52), “Cervical Squamous Cell Carcinoma” (38), and “Squamous Cell Carcinoma of the Skin” (19). The registry filed 177 of them under no condition at all, and the others under other conditions only, most often Uterine Cervical Neoplasms (62) and Carcinoma, Basal Cell (35).
- −1,389Match it another way525 name it in the title, 121 in a keyword, and 743 by a synonym or other text the search reads.
- 627The count on this page
Get an email when these change. Save the Carcinoma, Squamous Cell studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
M.D. Anderson Cancer Center (18) · Memorial Sloan Kettering Cancer Center (15) · Alpha Tau Medical LTD. (12) · UNC Lineberger Comprehensive Cancer Center (11) · National Cancer Institute (NCI) (9) · H. Lee Moffitt Cancer Center and Research Institute (9) · Vanderbilt-Ingram Cancer Center (8) · Merck Sharp & Dohme LLC (7)
What is being tested here
Drugs under test in Carcinoma, Squamous Cell studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Cisplatin | 5 | 3 | 32 |
| Docetaxel | 3 | 2 | 20 |
| Pembrolizumab | 3 | 2 | 17 |
| Nivolumab | 3 | 1 | 11 |
| Panitumumab | 3 | 0 | 9 |
| Cemiplimab | 3 | 2 | 6 |
| IRDye800 | 3 | 0 | 3 |
| Cetuximab | 2 | 0 | 19 |
| Carboplatin | 2 | 0 | 14 |
| Fluorouracil | 2 | 0 | 10 |
Drug classes tested here Immune checkpoint inhibitors 16 open · Antimitotic agents 4 open · Antimetabolites 4 open · Tyrosine kinase inhibitors (TKIs) 3 open · Alkylating agents 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jul 2027A Phase III Study With THIO + Cemiplimab vs Chemotherapy as 3rd Line Treatment in Advanced/Metastatic NSCLC · Phase 3 · Maia Biotechnology
- Aug 2027Nicotinamide Chemoprevention for Keratinocyte Carcinoma in Solid Organ Transplant Recipients - Pivotal Trial · Phase 3 · Women's College Hospital
- Aug 2027A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma · Phase 3 · AVEO Pharmaceuticals, Inc.
- Nov 2026Determining the Prevalence of Muir-Torre Syndrome in Patients With Lynch Syndrome · Centre Hospitalier Universitaire de Nīmes
- Nov 2026Anlotinib Hydrochloride Capsules Combined With TQB2450 Injection in Esophageal Squamous Cell Carcinoma Patients · Jiangxi Provincial Cancer Hospital
- Nov 2026Phase 2 Trial of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab in Patients With Newly Diagnosed PD-L1 CPS Positive Resectable Stage 3-4 Oral Cavity Squamous Cell Carcinoma (OCSCC). · M.D. Anderson Cancer Center
- Nov 2026Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery · Ryan Carey
- Dec 2026Alpha Radiation Emitters Device for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia (DaRT) · Alpha Tau Medical LTD.
- Dec 2026Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous SCC for Immunocompromised Patients · Alpha Tau Medical LTD.
- Dec 2026Screening for Anal Cancer in Men Who Have Sex With Men Using Pre-Exposure Prophylaxis · Universitair Ziekenhuis Brussel
Who these studies take
Of the 100 Carcinoma, Squamous Cell studies recruiting now, 84 (84%) set no upper age limit and 8 (8%) stop at 75 or younger. 7 (7%) take children under 18. 1 (1%) are for women only and 1 (1%) for men only; 9 (9%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 7 (7%) | 7 (7%) |
| 18 | 95 (95%) | 95 (95%) |
| 30 | 98 (98%) | 97 (97%) |
| 40 | 98 (98%) | 98 (98%) |
| 50 | 98 (98%) | 98 (98%) |
| 65 | 99 (99%) | 99 (99%) |
| 75 | 97 (97%) | 97 (97%) |
| 85 | 89 (89%) | 90 (90%) |
Across all 627 studies, recruiting or not: 10% stop at 75 or younger and 2% at 65; 7% take children; 2% are for women only and 1% for men only; 8% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Carcinoma, Squamous Cell studies take
Of 97 phase 2 interventional studies under Carcinoma, Squamous Cell, half reached primary completion within 61 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 40 mo32–62 · 42 studies | — | — |
| Phase 1/2 | 62 mo51–105 · 27 studies | — | — |
| Phase 2 | 61 mo37–82 · 97 studies | — | 61 mo44–82 · 86 studies |
| Phase 3 | 42 mo32–91 · 21 studies | — | — |
| Interventional, no phase | 81 mo27–137 · 53 studies | — | — |
| Observational | 139 mo24–248 · 43 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting4
- Ordastobart (INBRX-106) Add-on to Pembrolizumab in 1L HPV+ PD-L1+ R/M OPSCC (HexAgon-HN)Oct 27, 2026NCT06295731
- Basal Cell Carcinoma Chemoprevention TrialOct 19, 2026NCT05212246
- Window Trial of Intratumoral (IT) Neoadjuvant Fluorescently Labelled Nivolumab (nivo800) in Head and Neck Squamous Cell Carcinoma (HNSCC)Oct 19, 2026NCT07741565
- Study Evaluating the Safety and Feasibility of Panitumumab-IRDye800 and [18F]NOTA-ABY-030 for Targeted Dual-Modality Imaging (TDMI) in Head and Neck Squamous Cell CarcinomaOct 19, 2026NCT07741643
Results posted1
Stopped1
- Nivolumab and BMS986205 in Treating Patients With Stage II-IV Squamous Cell Cancer of the Head and NeckTerminatedOct 19, 2026NCT03854032
Newly registered4
- A Project Assessing the Safety and Feasibility of Using Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Ovarian Cancer During Surgical ProceduresNov 5, 2026NCT07919509
- Safety and Tolerability of Metformin and Naproxen for Cancer Prevention in Fanconi AnemiaOct 28, 2026NCT07901959
- Triplet Immunotherapy For Exhausted Cell Targets in Advanced Squamous Cell CarcinomaOct 27, 2026NCT07896811
- Cemiplimab and Quad Shot Radiation for Cutaneous Squamous Cell Carcinoma in the Head and NeckOct 13, 2026NCT07869823
Studies
Recruiting first, then most recently updated. Showing 50 of 627. Browse all 627 → or search them.
- Nivolumab Combined With Chemotherapy in the Treatment of Primary Tracheal Squamous Cell CarcinomaRecruitingNCT05964101Phase 21 country
- Tisotumab Vedotin in Squamous Cell Carcinoma of the VulvaNot yet recruitingNCT07672782Phase 21 country
- Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)RecruitingNCT04198766Phase 1/24 countries
- A Project Assessing the Safety and Feasibility of Using Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Ovarian Cancer During Surgical ProceduresNot yet recruitingNCT07919509Phase 11 country
- JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCCRecruitingNCT04892173Phase 327 countries
- Phase 1 Study Of TROP2 CAR/IL-15 TGFBR2 KO NK Cell In Patients With Oral Premalignant LesionsNot yet recruitingNCT07631013Phase 11 country
- Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC)Not yet recruitingNCT07552558Phase 1/21 country
- Basal Cell Carcinoma Chemoprevention TrialRecruitingNCT05212246Phase 31 country
- Expanded Access to Immunomodulatory AVM0703 for Solid Tumor and Blood Cancer PatientsAvailableNCT05974410
- Ordastobart (INBRX-106) Add-on to Pembrolizumab in 1L HPV+ PD-L1+ R/M OPSCC (HexAgon-HN)RecruitingNCT06295731Phase 2/313 countries
- Safety and Tolerability of Metformin and Naproxen for Cancer Prevention in Fanconi AnemiaRecruitingNCT07901959Phase 11 country
- Triplet Immunotherapy For Exhausted Cell Targets in Advanced Squamous Cell CarcinomaNot yet recruitingNCT07896811Phase 21 country
- Combining Neo-adjuvant ATR-inhibition With Nodal SBRT for Early-stage Resectable HPV+ OPSCCsNot yet recruitingNCT07578467Phase 1/2
- Intratumoral N17350 in Advanced Solid TumorsRecruitingNCT07339176Phase 1/22 countries
- T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung CancerRecruitingNCT02133196Phase 21 country
- PDT For Induction Therapy For Head And Neck CancerRecruitingNCT07214987Phase 21 country
- Study Evaluating the Safety and Feasibility of Panitumumab-IRDye800 and [18F]NOTA-ABY-030 for Targeted Dual-Modality Imaging (TDMI) in Head and Neck Squamous Cell CarcinomaRecruitingNCT07741643Phase 11 country
- Window Trial of Intratumoral (IT) Neoadjuvant Fluorescently Labelled Nivolumab (nivo800) in Head and Neck Squamous Cell Carcinoma (HNSCC)RecruitingNCT07741565Early Phase 11 country
- Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)RecruitingNCT07460765Phase 11 country
- Nicotinamide Chemoprevention for Keratinocyte Carcinoma in Solid Organ Transplant Recipients - Pivotal TrialRecruitingNCT05955924Phase 31 country
- Cemiplimab and Quad Shot Radiation for Cutaneous Squamous Cell Carcinoma in the Head and NeckRecruitingNCT07869823Early Phase 11 country
- A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid TumorsRecruitingNCT07115043Phase 1/24 countries
- Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid TumorsRecruitingNCT04429542Phase 13 countries
- Screening Psychosocial Distress in Head and Neck CancerNot yet recruitingNCT07851818
- The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding AreasRecruitingNCT07285044Phase 21 country
- Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain MetastasisRecruitingNCT06047379Phase 1/21 country
- Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck CancerRecruitingNCT06736379Phase 11 country
- Immunotherapy With Chemotherapy and Chemoradiation for Advanced Squamous Cancer of Nasal Cavity / Paranasal Sinuses (I-NAPA)RecruitingNCT05027633Phase 21 country
- Effects of Infusion Timing on Treatment Response in Solid TumorsRecruitingNCT07630168Phase 21 country
- Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION)RecruitingNCT07513389Phase 21 country
- Hair Regrowth Following Partial Thickness Removal of SSCISNot yet recruitingNCT07809191Not applicable
- A Study of IDP-001 in Advanced or Metastatic Solid TumorsRecruitingNCT07602842Phase 1/21 country
- Atorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck CancerRecruitingNCT04915183Phase 21 country
- Toripalimab With Chemotherapy for Sinus CancerRecruitingNCT06940180Phase 21 country
- Impact of Dysport on PMFF Donor ScarNot yet recruitingNCT07720726Phase 41 country
- Neoadjuvant Chemoradiotherapy Versus Neoadjuvant Immunochemotherapy for Resectable Esophageal Cancer: A Target Trial Emulation StudyNot yet recruitingNCT07778056
- Machine Learning Analysis of Two-photon Fluorescence Microscopy of Dermatologic BiopsiesRecruitingNCT07682831Not applicable1 country
- Two-photon Fluorescence Microscopy of Dermatologic BiopsiesRecruitingNCT07773688Not applicable1 country
- Vitamin D Effects on Immune Microenvironment of Nonmelanoma Skin Cancer After Photodynamic Therapy (PDT)RecruitingNCT07241585Not applicable1 country
- A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor CancerRecruitingNCT05859074Phase 11 country
- CLEAR (Cervical Lymphatic Exclusion in Adjuvant Radiation)RecruitingNCT07755449Phase 21 country
- Reflectance Confocal Microscopy of Oral Cancers in Vivo: a Preliminary Trial Comparing Intra-oral Imaging With PathologyRecruitingNCT025071411 country
- Window Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck CancerRecruitingNCT06819228Phase 11 country
- Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid TumorsRecruitingNCT07628634Early Phase 11 country
- Study on the Efficacy of Treatment by Radiotherapy and Pembrolizumab in Newly Diagnosed Metastatic Head & Neck CancersRecruitingNCT04747054Phase 31 country
- Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx CancerRecruitingNCT05388773Phase 21 country
- Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous SCC for Immunocompromised PatientsRecruitingNCT06615635Not applicable2 countries
- Diagnostic Performance Of 4D Dynamic LAFOV FDG-PET Acquisition for Differentiation of Residual Disease and Post-radiation Inflammation in Head Neck SCC Treated by Radiotherapy.RecruitingNCT074176051 country
- Nasal Reconstruction FACE-Q : French Validation of the Nasal Reconstruction FACE-Q Questionnaire for Reconstruction/Rehabilitation Following Nasal Skin CancerRecruitingNCT072570941 country
- Prospective Data Collection Initiative on Thoracic MalignanciesRecruitingNCT069962491 country