An interventional study of Partial Thickness Excision in Squamous Cell Carcinoma (Skin), Squamous Cell Carcinoma in Situ and Alopecia, sponsored by The Cooper Health System. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-09.
Sponsored by The Cooper Health System · Not applicable, Interventional, and Prevention
Participants are being approached to participate in this study because they are undergoing surgery for a skin cancer known as squamous cell carcinoma in situ (SCCIS) on the scalp. Standard surgical techniques may remove deeper structures that contain hair follicles, which can result in permanent hair loss. This study evaluates whether a modified surgical technique, known as partial thickness excision, can preserve hair growth and improve cosmetic outcomes. Participation involves minimal risk beyond the standard risks of Mohs surgery. If patients choose to participate, their surgery will be performed using this technique, and photographs will be taken over time to evaluate hair regrowth and healing.
Exclusion Criteria:
Participants will receive excision of their squamous cell carcinoma in situ of the scalp via partial thickness excision (removal of epidermal and superficial dermal tissue) in an effort to preserve hair follicles and hair growth potential.
Procedure: Partial Thickness Excision
Participants will receive excision of their squamous cell carcinoma in situ of the scalp via partial thickness excision (removal of epidermal and superficial dermal tissue) in an effort to preserve hair follicles and hair growth potential.
Hair Growth measured clinically by hair density percentage compared to baseline photo
To evaluate hair growth following partial thickness excision of SCCIS at 3 and 6 months post-procedure.
Time frame: 3 and 6 months post-procedure.
Clearance of SCCIS measured by Mohs surgeons' interpretation of margins on surgical slides.
To assess clinical and histologic clearance of SCCIS treated with partial-thickness excision.
Time frame: Immediately following the final Mohs stage during the index procedure
Patient Satisfaction measured via patient satisfaction questionnaire
To evaluate patient-reported satisfaction with hair density and cosmetic outcome. "Are you satisfied with amount of hair//appearance of skin/result of treatment?" etc. on scale of 1-10. 1 being not satisfied and 10 being very satisfied/.
Time frame: 3 and 6 months post-procedure
Complications
To document wound-healing, complications, and the need for additional treatment.
Time frame: 2 weeks post-procedure, 3 months post-procedure, and 6 months post-procedure
No study locations are listed for this record.
This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
The Cooper Health System