Azoospermia clinical trials
The registry lists 59 studies for Azoospermia across more than 10 countries. 17 are recruiting or about to start. 37 of them are mainly about Azoospermia (how this is decided). Per ClinicalTrials.gov, last updated 2026-07-01. Counting its narrower condition Azoospermia, Nonobstructive too: 74 studies, 20 open.
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Who runs them
Assiut University (5) · Cairo University (4) · Turku University Hospital (2) · Igenomix (2) · Sheba Medical Center (2) · Hadassah Medical Organization (2) · Man Clinic for Andrology, Male Infertility and Sexual Dysfunction (2) · Istituto Clinico Humanitas (2)
What is being tested here
Drugs under test in Azoospermia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Platelet rich plasma | 1 | 0 | 1 |
| Stem Cell | 0 | 0 | 2 |
| Clomiphene | 0 | 1 | 2 |
| Isotretinoin | 0 | 0 | 1 |
| Mesenchymal Stem Cell | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4
- Dec 2026Laterality Success Determination of Microscopic Testicular Sperm Extraction in Non Obstructive Azoopsermia Patients · Assiut University
- Dec 2026Platelet Rich Plasma Testis Treatment for Infertile Men · Stanford University
- Apr 2027Fertility Enhancement Through Regenerative Treatment in Ovaries and Testes · Jumeirah American Clinic
- Nov 2027IntelliWell: An AI-Assisted Imaging Platform for Detection and Location of Ultra-Rare Testicular Sperm in Surgical Specimens · Brigham and Women's Hospital
Who these studies take
Of the 13 Azoospermia studies recruiting now, 4 (31%) set no upper age limit and 6 (46%) stop at 75 or younger. 1 (8%) take children under 18. 0 (0%) are for women only and 11 (85%) for men only; 2 (15%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 1 (8%) | 9 (69%) |
| 30 | 2 (15%) | 13 (100%) |
| 40 | 2 (15%) | 13 (100%) |
| 50 | 2 (15%) | 11 (85%) |
| 65 | 1 (8%) | 7 (54%) |
| 75 | 1 (8%) | 7 (54%) |
| 85 | 1 (8%) | 6 (46%) |
Across all 59 studies, recruiting or not: 64% stop at 75 or younger and 63% at 65; 15% take children; 0% are for women only and 86% for men only; 24% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 59. Browse all 59 → or search them.
- Intra-Testicular Transplantation of Autologous Stem Cells for Treatment of Non-Obstructive Azoospermia Male Infertility.RecruitingNCT02641769Phase 1/21 country
- IntelliWell: An AI-Assisted Imaging Platform for Detection and Location of Ultra-Rare Testicular Sperm in Surgical SpecimensRecruitingNCT07074015Not applicable1 country
- Fertility Restoration With Autografting of Cryopreserved Immature Testicular TissueRecruitingNCT07542626Not applicable1 country
- Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI)RecruitingNCT073577011 country
- Male Factor Infertility Across India Using Aphrodite CriteriaNot yet recruitingNCT069118401 country
- Evaluating the Safety and Clinical Efficacy of the BAIBYS™ System in Intracytoplasmic Sperm Injection (ICSI)Not yet recruitingNCT06990906Not applicable3 countries
- Platelet Rich Plasma Testis Treatment for Infertile MenRecruitingNCT05479474Not applicable1 country
- Laterality Success Determination of Microscopic Testicular Sperm Extraction in Non Obstructive Azoopsermia PatientsNot yet recruitingNCT07259967
- Testicular Evaluation of Azoospermia Using Micro-UltrasoundRecruitingNCT069419222 countries
- Testicular Sperm Retrieval Rate After Varicocele Ligation in Men With Non Obstructive AzoospermiaRecruitingNCT07008495Not applicable1 country
- Fertility Enhancement Through Regenerative Treatment in Ovaries and TestesRecruitingNCT068413281 country
- Study of Tolerability, Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of the Medicinal Product MediReg®RecruitingNCT06869863Phase 1/21 country
- Testis Needle Aspiration of Sperm in Men With AzoospermiaRecruitingNCT02418832Not applicable1 country
- The Association of Gut Microbiota and Spermatogenic DysfunctionRecruitingNCT056289871 country
- Seminal Levels of PGK2 and ACRV1 as Predictors of Micro-TESE Results in NOANot yet recruitingNCT06307639
- Testicular Proteins for Sperm Retrieval Prediction Protein1, Testis-Expressed Gene 101, and Lectin Galactoside-binding Protein in Predicting Surgical Sperm Retrieval in Men With Non-Obstructive AzoospermiaRecruitingNCT061549541 country
- The Potential of Sperm Retrieved by Micro-TESE to Fertilize Vitrified/Warmed OocytesRecruitingNCT038090261 country
- Interest of Clomiphene Citrate in Patients With Non-obstructive Azoospermia on the Quantity of Sperm CellsWithdrawnNCT03615547Phase 31 country
- Fertility Preservation in Cases of Klinefelter Syndrome.CompletedNCT01918280Not applicable1 country
- Testicular Elastography for Microscopic Testicular Sperm ExtractionCompletedNCT06524258Not applicable1 country
- Testicular Sperm Aspiration (TESA) vs. Microfluidic Sperm Separation (MSS)CompletedNCT058664841 country
- Relationship Between Anogenital Distance, Serum AMH, and mTESE in Klinefelter SyndromeCompletedNCT063961171 country
- Comparison of Medical Results of Testicular Sperm Extraction by Conventional Surgery and Microsurgical TrackTerminatedNCT02773498Not applicable1 country
- Laser Assisted Sperm Selection of Viable Immotile Testicular Sperm in Azoospermic Infertile MenCompletedNCT04675164Not applicable1 country
- Modern Analyses of the Semen in Evaluating Male Fertility and Treatment Options of Male InfertilityCompletedNCT029328651 country
- Treatment of Severe Male Infertility - Predictive Factors (Imaging)CompletedNCT029317211 country
- Gabapentin for Post-Operative Pain Control and Narcotic Reduction in Scrotal SurgeryCompletedNCT04230980Phase 31 country
- Effect of Age on Sperm Recovery of Microdissection Testicular Sperm Extraction in Nonobstructive Azoospermia PatientsCompletedNCT059585761 country
- MSCs For Treatment of Azoospermic PatientsCompletedNCT02025270Phase 1/21 country
- Sperm Retrieval Rates in Non-obstructive Azoospermic Men Subjected to Gonadotropin TherapyCompletedNCT051103911 country
- Standard IV Cannula Aspiration (SIVCA): A Novel, Efficient and Minimally Invasive Testicular Sperm Aspiration TechniqueCompletedNCT05247723Not applicable1 country
- Detection of Microdeletions in the Azoospermia Factor (AZF) Regions in Infertile Male PatientsTerminatedNCT034977281 country
- RA-4: 13-cis Retinoic Acid for Treatment of Men With AzoospermiaCompletedNCT03323801Phase 21 country
- Surgical Sperm Retrieval in Non-obstructive Azoospermic Men: mTESE vs. TESACompletedNCT03550716Not applicable2 countries
- Role of Transrectal-ultrasound in Evaluation of AzoospermiaStatus unknownNCT05026190Not applicable
- Reproductive and Obstetric Outcomes in TESE-ICSI Cycles for AzoospermiaCompletedNCT04894136
- Round Spermatid Injection ProtocolTerminatedNCT040533091 country
- Is the Lack of Prior Exposure to Sperm Antigens Associated With Worse Neonatal and Maternal Outcomes?CompletedNCT04852237
- Autologous Adipose-Derived Adult Stromal Vascular Cell Administration for Male Patients With InfertilityStatus unknownNCT03762967Phase 21 country
- Assessing the Efficacy of Clomiphene Citrate in Patients With Azoospermia and HypoandrogenismWithdrawnNCT02137265Not applicable1 country
- Seminal TEX101 as a Predictor of Recovery of Spermatogenesis in Azoospermic Men With Palpable VaricoceleCompletedNCT04397887Not applicable1 country
- Anti-mullerian Hormone,Testesterone,Esrtadiol,Testesterone/Esrtadiol Ratio as Predictive Values for TESA and TESE Outcome in Non Obstructive AzoospermiaStatus unknownNCT04308486
- Quantitative MRI for Functional Imaging of the Testis: A New Methodology for Evaluation of the Infertile MaleWithdrawnNCT02756325Not applicable
- TESE and Non Obstructive AzoospermiaStatus unknownNCT03146260Not applicable
- GnRHa Combined With hCG and hMG for Treatment of Patients With Non-obstructive AzoospermiaStatus unknownNCT02544191Phase 21 country
- The Effect of Low Electrical Current on Testicular Spermatocyte CountStatus unknownNCT02617173Not applicable1 country
- Obtaining Undifferentiated Cells From Testis BiopsyCompletedNCT01375062Not applicable1 country
- Sperm Production in Kleinfelter Syndrome Patients After Mesenchymal Stem Cell InjectionCompletedNCT02414295Not applicable1 country
- Intra Testicular Artery Injection of Bone Marrow Stem Cell in Management of AzoospermiaStatus unknownNCT02008799Not applicable1 country
- Study of Synapsis and Recombination in Male Meiosis and the Implications in InfertilityCompletedNCT023392721 country