Infertility, Male clinical trials
The registry lists 282 studies for Infertility, Male across more than 10 countries. 65 are recruiting or about to start. 204 of them are mainly about Infertility, Male (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 4 narrower conditions too, such as Oligospermia: 376 studies, 89 open.
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Status
Who runs them
Weill Medical College of Cornell University (8) · IRCCS San Raffaele (7) · Assiut University (7) · Martin Blomberg Jensen (5) · Benha University (4) · Assistance Publique - Hôpitaux de Paris (4) · Radboud University Medical Center (3) · ART Fertility Clinics LLC (3)
What is being tested here
Drugs under test in Infertility, Male studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Aromatase inhibitors 4
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- May 2027Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI) · Phase 3 · University of Miami
- Jun 2027Comparative Study of Post-Varicocelectomy Myo-inositol vs. Antioxidants vs. Surgery Alone in Infertile Men · Phase 3 · Fayoum University Hospital
- Oct 2027PKB171 Against Placebo in Couples With Mild Male Factor Infertility · Phase 3 · Prokrea BCN, S.L.
- Dec 2026Preimplantation Genetic Testing for Aneuploidy (PGT-A) in Couples With Non-obstructive Azoospermia (NOA) · Inception Fertility Research Institute, LLC
- Dec 2026Comparison of Two Types of Calcium (Ca²⁺) Ionophore Treatments for Oocyte Activation in Cases of Suboptimal Fertilization Potential · ART Fertility Clinics LLC
- Dec 2026Royal Jelly Supplementation in Unexplained Male Infertility · Medipol University
- Dec 2026Spermatogonial Differentiation Via Testicular Organoid · CellARTs Inc.
- Dec 2026Live Birth Rate Between ICSI and AOA and ICSI Alone in Patients With Severe Teratospermia · ShangHai Ji Ai Genetics & IVF Institute
- Dec 2026Measuring Free Radicals in Human Sperm Cells Related to Microbiota and Lifestyle Factors · University Medical Center Groningen
- Dec 2026Probiotics on Sperm Quality in Male Infertility Patients · Mackay Memorial Hospital
Who these studies take
Of the 40 Infertility, Male studies recruiting now, 16 (40%) set no upper age limit and 24 (60%) stop at 75 or younger. 7 (18%) take children under 18. 0 (0%) are for women only and 32 (80%) for men only; 14 (35%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (5%) | 7 (18%) |
| 18 | 6 (15%) | 35 (88%) |
| 30 | 7 (18%) | 39 (98%) |
| 40 | 6 (15%) | 38 (95%) |
| 50 | 5 (13%) | 28 (70%) |
| 65 | 4 (10%) | 16 (40%) |
| 75 | 4 (10%) | 16 (40%) |
| 85 | 4 (10%) | 16 (40%) |
Across all 282 studies, recruiting or not: 72% stop at 75 or younger and 71% at 65; 10% take children; 5% are for women only and 76% for men only; 34% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Infertility, Male studies take
Of 92 interventional studies with no phase under Infertility, Male, half reached primary completion within 34 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 34 mo17–50 · 92 studies | — | 28 mo17–50 · 77 studies |
| Observational | 59 mo21–129 · 40 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting1
- A Novel Aromatase Inhibitor, Leflutrozole, for Treatment of Non-Obstructive AzoospermiaOct 16, 2026NCT07571928
Stopped1
- FSH in Azoospermic MenWithdrawnOct 29, 2026NCT02275169
Newly registered3
- Letrozole in Oligospermia With Eugonadotropic-Hypogonadism and Low Testosterone Estradiol RatioNov 6, 2026NCT07922512
- Comparative Study of Post-Varicocelectomy Myo-inositol vs. Antioxidants vs. Surgery Alone in Infertile MenNov 4, 2026NCT07915388
- YO® Smartphone Home Sperm Test Versus Manual Semen Analysis in Egyptian MenOct 19, 2026NCT07880288
Studies
Recruiting first, then most recently updated. Showing 50 of 282. Browse all 282 → or search them.
- Assessing the Correlation Between Phospholipase C Zeta Measurements and Semen ParametersRecruitingNCT076843391 country
- Comparative Study of Post-Varicocelectomy Myo-inositol vs. Antioxidants vs. Surgery Alone in Infertile MenNot yet recruitingNCT07915388Phase 31 country
- Comparative Efficacy of Antioxidants Alone Versus Combined Therapy With SERMs or FSH in Normogonadotropic Idiopathic OAT Patients: A Randomized Controlled TrialNot yet recruitingNCT07862725Phase 41 country
- Experimental Round Spermatid Injection (ROSI) to Treat Infertile CouplesRecruitingNCT04298255Not applicable1 country
- Efficacy and Safety of a New Sperm Capacitation MethodRecruitingNCT067424371 country
- Nordic Sperm DNA StudyNot yet recruitingNCT07779954Not applicable
- Effectiveness of Live Motile Sperm Sorting Device on IVF Outcomes in Advanced Paternal AgeRecruitingNCT07605182Not applicable1 country
- Royal Jelly Supplementation in Unexplained Male InfertilityRecruitingNCT07337265Not applicable1 country
- Maternal Inheritance of a Pathogenic MT-ND1 Mutation Causes Mitochondrial Dysfunction and Spermatogenic Failure in MenRecruitingNCT076918271 country
- Effect of Varicocelectomy on Spermatogenic Cell Count and Semen ParametersNot yet recruitingNCT07684963Not applicable
- PKB171 Against Placebo in Couples With Mild Male Factor InfertilityRecruitingNCT07669584Phase 2/31 country
- Single Infrapubic Versus Bilateral Subinguinal Microsurgical VaricocelectomyRecruitingNCT07650955Not applicable1 country
- Development of an AI Platform for the Analysis of Sperm and Prediction of Their Clinical PotentialRecruitingNCT074563971 country
- Male Infertility and Assisted Reproductive Technologies Research BiobankRecruitingNCT068803021 country
- Selective Extended Venous Stripping Versus Standard Microsurgical Varicocelectomy for Varicocele-Related Male InfertilityNot yet recruitingNCT07605351Not applicable1 country
- Comparison of Two Types of Calcium (Ca²⁺) Ionophore Treatments for Oocyte Activation in Cases of Suboptimal Fertilization PotentialNot yet recruitingNCT07570342Not applicable
- Measuring Free Radicals in Human Sperm Cells Related to Microbiota and Lifestyle FactorsRecruitingNCT055142231 country
- Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue GraftingRecruitingNCT04452305Not applicable1 country
- Gonadotropin Therapy in Idiopathic Hypogonadal Non-ObstructiveNot yet recruitingNCT07540611Not applicable1 country
- Comparison of the Effect of Gonadotropin and Clomiphene Citrate Treatment on Sperm Parameters and the Outcome of Assisted Reproductive Procedures in Subfertile Men Based on the APHRODITE GroupsEnrolling by invitationNCT07523022Phase 41 country
- Intratesticular Artery Resistive Index Changes After VaricocelectomyNot yet recruitingNCT07517952Not applicable
- Establishment of a Primary Epididymal Cell Model From Epididymal Samples to Study CFTR Gene RegulationRecruitingNCT060457021 country
- Effect of Daily Intake of Gazpacho on Semen Quality and Oxidative StressRecruitingNCT07375238Not applicable1 country
- Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI)RecruitingNCT05903859Phase 31 country
- Live Birth Rate Between ICSI and AOA and ICSI Alone in Patients With Severe TeratospermiaRecruitingNCT06561451Not applicable1 country
- Embryo Assessment Utilizing Timelapse Imaging in Conjunction With Preimplantation Genetic Testing for Aneuploidy With Next Generation SequencingEnrolling by invitationNCT064191271 country
- Male Factor Infertility Across India Using Aphrodite CriteriaNot yet recruitingNCT069118401 country
- Evaluating the Safety and Clinical Efficacy of the BAIBYS™ System in Intracytoplasmic Sperm Injection (ICSI)Not yet recruitingNCT06990906Not applicable3 countries
- Probiotics on Sperm Quality in Male Infertility PatientsRecruitingNCT07345455Not applicable1 country
- Platelet Rich Plasma Testis Treatment for Infertile MenRecruitingNCT05479474Not applicable1 country
- Warfarin Effects on Male Fertility After Cardiac SurgeryNot yet recruitingNCT073308691 country
- Biobank Aimed to Study Gynecological Pathologies, of Male and Female Infertility and Pregnancy PathologiesEnrolling by invitationNCT072659081 country
- Functional Development and Clinical Validation of a Diagnostic Tool Based on Artificial Intelligence for the Assessment of Sperm Quality and the Selection of the Optimal In Vitro Fertilisation (IVF) TreatmentNot yet recruitingNCT071859841 country
- Can Fat-Burning Shots Boost Fertility? Comparing Weight-Loss Injections vs. Healthy Habits for Obese Men With Low Sperm HealthNot yet recruitingNCT07179120Phase 2
- Cell Free Preimplantation Genetic TestingNot yet recruitingNCT046285071 country
- Survey of Patients Who Received Fertility Preservation Counseling and Underwent Testicular Tissue Cryopreservation Prior to Gonadotoxic Treatment During Childhood or PeripubertyEnrolling by invitationNCT07140549Not applicable1 country
- Efficacy Study of a Food Supplement With Myo-inositol, N-Acetyl-Cystein, Zinc and Vitamins on Sperm DNA FragmentationRecruitingNCT04959864Not applicable1 country
- Effect of Graminex on Infertility Related to Male Accessory Glands InflammationNot yet recruitingNCT06974175Not applicable1 country
- The Efficiency of a New Sperm-Wash Device for Intrauterine Insemination in Couples With InfertilityRecruitingNCT06956287Not applicable1 country
- The Effect of Supplementation With Fish Oil (EPAX EVOLVE 05) on Sperm QualityRecruitingNCT06950203Not applicable1 country
- Prospective Study on Power Prenatal Vitamins for Males on YO Score At-home Sperm Test ResultsRecruitingNCT05951075Not applicable1 country
- Power Prenatal Supplements for Sperm QualityRecruitingNCT05410782Not applicable1 country
- Study to Verify the Efficacy of a Product Containing 125 mg of TetraSOD® for the Treatment of Male InfertilityRecruitingNCT06324071Not applicable1 country
- Spermatogonial Differentiation Via Testicular OrganoidRecruitingNCT06841861Phase 1/21 country
- Aftificial Inteligence in Assisted Reproductive Techniques to Assess Oocyte Quality and Embryo PloidyRecruitingNCT065391041 country
- Supplementation for Male SubfertilityNot yet recruitingNCT06091969Phase 21 country
- Knowledge and Attitude Towards Fertility Among Emirati Infertile PatientsRecruitingNCT062502311 country
- The Association of Gut Microbiota and Spermatogenic DysfunctionRecruitingNCT056289871 country
- Role of Immunoglobulin in Male InfertilityRecruitingNCT06423989Not applicable1 country
- Level of DNA-fragmentation Before and After Antioxidant-based Therapies in Male InfertilityNot yet recruitingNCT06050031