An observational study in Azoospermia, Nonobstructive, sponsored by Odense University Hospital. Recruiting at 2 sites in Denmark. Open to male participants aged 18 Years to 100 Years. Per ClinicalTrials.gov, last updated 2023-11-02.
Sponsored by Odense University Hospital · Observational
Couples referred for microdissection-TESE (m-TESE) due to Klinefelter's syndrome, maturation stop in the spermatogenesis, or failed retrieval of testicular spermatozoa by conventional techniques with needle or TruCut are included. The women are stimulated with FSH in IVF protocols and the aspirated oocytes vitrified with usual applied techniques. Fresh sperm retrieved by micro-TESE are used for fertilization of the warmed oocytes. when it is not possible to obtain testicular sperm, the couples are offered fertilization with warmed oocytes.
Fertilization, cleavage, implantation and pregnancy rates using sperm from the patients versus from sperm donors will be compared.
Men referred to micro-TESE due to Klinefelter's syndrome, maturation stop in the spermatogenesis, or failed sperm retrieval using conventional needles or TruCut.
Couples referred for micro-TESE
Exclusion Criteria:
None
Couples where the men have Klinefelter's syndrome, maturation stop in the spermatogenesis or failed retrieval of testicular sperm by conventional techniques with needle or TruCut, and where testicular sperm could be obtained by micro-TESE.
Couples as in the study group, but where testicular sperm could not be obtained by micro-TESE. The oocytes therefore must be fertilized using donor sperm.
Cleavage rate
Measurement of % of cleavage among the warmed oocytes
Time frame: six years
Pregnancy rate
Measurement of serum-hCG and ultrasonography at gestation age week 7
Time frame: six years
Fertilization rate
Measurement of % of fertilization among the warmed oocytes
Time frame: six years
Implantation rate
Measurement of the % of transferred embryos implanting into the uterus
Time frame: six years
Plan to share: Undecided
No publications or documents are linked to this record.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Odense University Hospital