An observational study in Azoospermia, Nonobstructive, sponsored by Odense University Hospital. Recruiting at 2 sites in Denmark. Open to male participants aged 18 Years to 100 Years. Per ClinicalTrials.gov, last updated 2023-11-02.
Sponsored by Odense University Hospital · Observational
Couples referred for microdissection-TESE (m-TESE) due to Klinefelter's syndrome, maturation stop in the spermatogenesis, or failed retrieval of testicular spermatozoa by conventional techniques with needle or TruCut are included. The women are stimulated with FSH in IVF protocols and the aspirated oocytes vitrified with usual applied techniques. Fresh sperm retrieved by micro-TESE are used for fertilization of the warmed oocytes. when it is not possible to obtain testicular sperm, the couples are offered fertilization with warmed oocytes.
Fertilization, cleavage, implantation and pregnancy rates using sperm from the patients versus from sperm donors will be compared.
23 studies on the registry are indexed under Azoospermia, Nonobstructive; 7 are open to participants now.
This study's planned enrollment of 100 is close to the median of 94 across 10 observational studies indexed under Azoospermia, Nonobstructive.
Browse Azoospermia, Nonobstructive studies →Odense University Hospital is the lead sponsor of 479 studies on the registry; 110 are open to participants now.
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Men referred to micro-TESE due to Klinefelter's syndrome, maturation stop in the spermatogenesis, or failed sperm retrieval using conventional needles or TruCut.
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Couples referred for micro-TESE
Exclusion Criteria:
None
Couples where the men have Klinefelter's syndrome, maturation stop in the spermatogenesis or failed retrieval of testicular sperm by conventional techniques with needle or TruCut, and where testicular sperm could be obtained by micro-TESE.
Couples as in the study group, but where testicular sperm could not be obtained by micro-TESE. The oocytes therefore must be fertilized using donor sperm.
Cleavage rate
Measurement of % of cleavage among the warmed oocytes
Time frame: six years
Pregnancy rate
Measurement of serum-hCG and ultrasonography at gestation age week 7
Time frame: six years
Fertilization rate
Measurement of % of fertilization among the warmed oocytes
Time frame: six years
Implantation rate
Measurement of the % of transferred embryos implanting into the uterus
Time frame: six years
Plan to share: Undecided
No publications or documents are linked to this record.
Started Sep 2015 (actual). Primary completion is estimated for Dec 2023, 99 months after the start.
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