An interventional study of Clomiphene and Placebo in Non Obstructive Azoospermia and Hypogonadism, sponsored by University of Illinois at Chicago. Withdrawn at 1 site in Spain. Open to male participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-10-05.
Sponsored by University of Illinois at Chicago · Not applicable, Interventional, and Treatment
Hypothesis: Prescribed clomiphene citrate to azoospermic patients with hypoandrogenism could improve the sperm retrieval in either fresh sperm or after surgical sperm extraction.
Hypogonadism (low testosterone level) is frequently observed in men presenting with non obstructive azoospermia. Controversy exists regarding the efficacy of preoperative hormonal manipulation in patients with hypogonadism. However, it is possible that hormonal therapy increases intra-testicular testosterone levels, and with a rise in serum testosterone, sperm production and surgical success with microTESE improve.
320 studies on the registry are indexed under Hypogonadism; 39 are open to participants now.
Browse Hypogonadism studies →University of Illinois at Chicago is the lead sponsor of 506 studies on the registry; 120 are open to participants now.
Of its 32 completed or terminated interventional studies of FDA-regulated products, 19 (59%) have results posted.
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Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
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A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
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Clomiphene citrate 50 mg daily during 4-6 months
Drug: Clomiphene
Placebo (1 pill daily) during 4-6 months
Drug: Placebo
Clomiphene citrate 50 mg orally daily
Also known as: Clomid, Serophene
One pill every other day
Also known as: control
Presence of sperm in the ejaculated or in the microsurgical testicular Sperm extraction (microTESE)
Time frame: After four months of clomiphene treatment
Epigenetic modifications
Time frame: After four months of clomiphene treatment
Testosterone levels and Bioavailable Testosterone levels
Time frame: After two weeks and four months with clomiphene treatment
The record gives a start of Sep 2015, a primary completion of Oct 2020 and a completion of Oct 2020. It does not say whether these dates are actual or estimated.
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This study is withdrawn, as verified in Oct 2020. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Clomiphene
University of Illinois at Chicago →