Not yet recruitingNCT06307639Updated Mar 13, 2024

Seminal Levels of PGK2 and ACRV1 as Predictors of Micro-TESE Results in NOA

An observational study in Male Infertility Due to Azoospermia, sponsored by Assiut University. Not yet recruiting. Open to male participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-03-13.

Sponsored by Assiut University · Observational

From the registry’s dates

Primary completion was expected by Oct 2025, 1 year 1 month ago, but the record still lists the study as not yet recruiting.

Study type: Observational
Model: Case-control
Time perspective: Prospective
Enrollment: 64
Ages: 18 Years to 45 Years
Sex: Male

Study summary

Measurement of PGK2 and ACRV1 levels in the semen of infertile males undergoing testicular sperm extraction (TESE).
Correlate seminal levels of PGK2 and ACRV1 with sperm retrieval results and histopathology analysis of testicular biopsy samples.

Conditions studied

Male Infertility Due to Azoospermia

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In context

Azoospermia

59 studies on the registry are indexed under Azoospermia; 17 are open to participants now.

This study's planned enrollment of 64 is below the median of 95 across 24 observational studies indexed under Azoospermia.

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Lead sponsor

Assiut University is the lead sponsor of 5,078 studies on the registry; 2,178 are open to participants now.

Of its 14 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

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Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 18 Years to 45 Years
Sexes eligible: Male
Accepts healthy volunteers: Yes
Sampling method: Non-probability sample

Study population

Infertile males with normal volume, functional (non-obstructive) azoospermia.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

Infertile males with normal volume, functional (non-obstructive) azoospermia.
Age: 18-45 years

Exclusion criteria

Exclusion Criteria:

Patients with proven obstructive azoospermia.
Cryptorchidism.
Testicular Agenesis and testicular atrophy.
Patient with exposure to gonadal toxins like chemotherapy, radiotherapy, and alkylating agents.

Study design

Observational model: Case-control
Time perspective: Prospective
Enrollment: 64 participants (estimated)
Target follow-up: 3 Months
Patient registry: Yes

Interventions

Diagnostic testMeasurement of PGK2 and ACRV1 levels in the semen of infertile males undergoing testicular sperm extraction (TESE).
Measurement of PGK2 and ACRV1 levels in the semen of infertile males undergoing testicular sperm extraction (TESE).

What researchers measure

Primary outcomes

Know more about the functional role of PGK2 and ACRV1 in the process of spermatogenesis.
Time frame: 2 years
Detect if PGK2 and/or AVRV1 level can used as predictor for spermatogenesis in infertile men with non-obstructive azoospermia undergoing Testicular Sperm Extraction.
Time frame: 2 years

Study locations

No study locations are listed for this record.

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

Timeline

Tracking since Sep 25, 2026

ElapsedEstimatedEstimated, not yet reached

Start is estimated for Apr 2024; primary completion for Oct 2025, 18 months later.

How these figures are worked out, and which studies are left out of them.

Registered: Mar 6, 2024
First posted: Mar 13, 2024
StartEst.: Apr 1, 2024
Primary completionEst.: Oct 1, 2025
CompletionEst.: Apr 1, 2026
Last update: Mar 13, 2024

What these dates mean

Start.: When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.: When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.: When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.: Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.

No changes since tracking began. The registry record was last updated on Mar 13, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT06307639
Lead sponsor: Assiut University
Responsible party: Muhammad Yousef Muhammad Swifee (Assistant lecturer of Andrology ,Sexology and STIs, Assiut University) — Principal investigator
First posted: Mar 13, 2024
Start date: Apr 1, 2024 (estimated)
Primary completion: Oct 1, 2025 (estimated)
Completion: Apr 1, 2026 (estimated)
Last update: Mar 13, 2024

Oversight

Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Mar 2024. You cannot join it, but the record below documents what was studied.

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Discussion

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