Angina Pectoris, Variant clinical trials
The registry lists 34 studies for Angina Pectoris, Variant across more than 10 countries. 10 are recruiting or about to start. 18 of them are mainly about Angina Pectoris, Variant (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-04.
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Status
Who runs them
Korea Otsuka Pharmaceutical Co., Ltd. (3) · Radboud University Medical Center (2) · Roxane Laboratories (2) · Seung-Jung Park (2) · Samsung Medical Center (2) · Luzerner Kantonsspital (1) · NHS Greater Glasgow and Clyde (1) · Yonsei University (1)
What is being tested here
Drugs under test in Angina Pectoris, Variant studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Amlodipine | 1 | 1 | 3 |
| Nebivolol | 1 | 1 | 1 |
| Atorvastatin | 0 | 0 | 3 |
| Cilostazol | 0 | 2 | 2 |
| Nitrates | 0 | 0 | 1 |
| Vericiguat | 0 | 0 | 1 |
| Ascorbic Acid | 0 | 0 | 1 |
| Vitamin E | 0 | 0 | 1 |
| Bisoprolol | 0 | 0 | 1 |
| Diltiazem | 0 | 0 | 1 |
Drug classes tested here Calcium channel blockers 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3, phase 3 first
- Dec 2026Efficacy of Targeted Medical Therapy in Angina and Nonobstructive Coronary Arteries · Phase 3 · Stanford University
- Jan 2027Comprehensive Coronary Physiology in Patients With Angina With Nonobstructive Coronary Arteries - Czech Republic · University Hospital, Motol
- Feb 2027Cardioneuroablation for Variant Angina · Zhibing Lu
Who these studies take
Of the 9 Angina Pectoris, Variant studies recruiting now, 8 (89%) set no upper age limit and 1 (11%) stop at 75 or younger. 1 (11%) take children under 18. 1 (11%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (11%) | 1 (11%) |
| 18 | 8 (89%) | 8 (89%) |
| 30 | 8 (89%) | 8 (89%) |
| 40 | 9 (100%) | 8 (89%) |
| 50 | 9 (100%) | 8 (89%) |
| 65 | 9 (100%) | 8 (89%) |
| 75 | 9 (100%) | 8 (89%) |
| 85 | 8 (89%) | 8 (89%) |
Across all 34 studies, recruiting or not: 15% stop at 75 or younger and 6% at 65; 15% take children; 6% are for women only and 3% for men only; 15% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Invasive Evaluation and Phenotype-Guided Treatment of ANOCA in WomenNov 4, 2026NCT07593157
Studies
Recruiting first, then most recently updated. Showing 34 of 34. search them.
- Invasive Evaluation and Phenotype-Guided Treatment of ANOCA in WomenRecruitingNCT07593157Not applicable1 country
- Gangwon PCI Prospective RegistryRecruitingNCT020381271 country
- Implantable Cardioverter Defibrillator Versus Optimal Medical Therapy In Patients With Variant Angina Manifesting as Aborted Sudden Cardiac DeathRecruitingNCT02845531Phase 41 country
- iCorMicA - Stratified Medicine in AnginaRecruitingNCT04674449Not applicable4 countries
- POLish Registry of CArdioneuroablation and CArdioneuromodulationRecruitingNCT071963971 country
- Comprehensive Coronary Physiology in Patients With Angina With Nonobstructive Coronary Arteries - Czech RepublicRecruitingNCT071033171 country
- Efficacy of Targeted Medical Therapy in Angina and Nonobstructive Coronary ArteriesRecruitingNCT06424834Phase 2/31 country
- Efficacy of Endothelin Receptor Antagonism in Coronary Artery SpasmEnrolling by invitationNCT06432452Phase 2/31 country
- Transcutaneous Electrical Nerve Stimulation in Patients With Angina and Non-Obstructive Coronary ArteriesRecruitingNCT06401291Not applicable1 country
- Myocardial Ischemia Without Obstructive Coronary StenosesRecruitingNCT048274981 country
- The Impact of Vericiguat on Microvascular Function in Patients With Documented Vasospastic Angina PectorisCompletedNCT06415227Phase 21 country
- ANti-Oxidant in Variant Angina (ANOVA) TrialTerminatedNCT03228238Phase 41 country
- Cardioneuroablation for Variant AnginaActive, not recruitingNCT06992830Not applicable1 country
- Immunomodulatory Therapy & VSACompletedNCT066968071 country
- Coronary Microvascular Function and CT Coronary Angiography (CorCTCA)Active, not recruitingNCT03477890Not applicable1 country
- Prognostic Value of Precision Medicine in Patients With MINOCA (PROMISE Trial).Active, not recruitingNCT05122780Phase 41 country
- Assessing the Effect of the 'Wavy' Application, on Stress and Burden of Disease in Women With INOCACompletedNCT06171893Not applicable1 country
- BVS Implantation in Patients With Variant Angina and MODerate Coronary Artery DiseaseWithdrawnNCT02932553Phase 41 country
- ReACHallenge Trial: Acetylcholine Rechallenge After Pretreatment With Vasoactive DrugsStatus unknownNCT05618132Not applicable1 country
- Coronary Microcirculatory Disease and Inflammation in Patients With Chronic Coronary Syndrome and no Significant Coronary Artery StenosisStatus unknownNCT053139191 country
- Randomized Trial to Examine a Differential Therapeutic Response in Symptomatic Patients With Non-obstructive Coronary Artery DiseaseStatus unknownNCT05294887Phase 42 countries
- A Multi-Omics Study of Vasospastic AnginaStatus unknownNCT052825111 country
- Time Gain in the Diagnosis Myocardial Infarction by Troponin Point of Care Testing in the Emergency RoomCompletedNCT029728141 country
- Multidetector Coronary CT In Vasospastic AnginaStatus unknownNCT02180971Not applicable1 country
- The Effect of Sarpogrelate and High Dose Statin on the Reduction of Coronary SpasmStatus unknownNCT01674686Phase 41 country
- Bioequivalency Study of Amlodipine Tablets Under Fasting ConditionsCompletedNCT00602017Not applicable1 country
- Bioequivalency Study of Amlodipine Tablets Under Fed ConditionsCompletedNCT00601302Not applicable1 country
- Statin Therapy In Patients With Vasospastic AnginaWithdrawnNCT02790528Phase 41 country
- A Therapeutic Confirmatory Study to Evaluate the Efficacy and Safety of Cilostazol in Subjects With Vasospastic AnginaCompletedNCT02087007Phase 31 country
- Safety and Efficacy Study of Cilostazol to Treat Vasospastic AnginaCompletedNCT02094469Phase 31 country
- Angina in Non Coronary Artery DiseaseStatus unknownNCT013186291 country
- Evaluate the Efficacy and Safety of Pletaal (Cilostazol) in Subjects With Vasospastic AnginaCompletedNCT01444885Phase 21 country
- Efficacy Study of Atorvastatin to Treat Variant AnginaStatus unknownNCT00620204Phase 41 country
- Determination of Variances in Exhaled Nitric Oxide Output in Normal Healthy Male Volunteers Consuming High and Low Nitrate/Nitrite DietsCompletedNCT000271571 country