An interventional study of Positive CAG with EG test and Negative CAG with EG test in Vasospastic Angina, sponsored by Dong-A University. Status unknown at 1 site in Korea, Republic of. Open to participants aged 20 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-07-22.
Sponsored by Dong-A University · Not applicable, Interventional, and Diagnostic
The purpose of this study is to compare the extent of coronary vessel stenosis between coronary spasm-induced angina attacks (named vasospastic angina, VSA) patients and health volunteers by multi-detector computed tomography angiography (MDCTA), and to evaluate the diagnostic efficacy of MDCTA in patients with VSA.
Vasospastic angina (VSA) was characterized by transient ischemic ST-segment change during angina attacks. Coronary spasm provocation test, as a diagnostic golden standard, has been widely used for the management of VSA according to JCS 2013 guidelines.
With regard to the characteristics of spasm segment, had been clearly described by other invasive imaging methods including intravascular ultrasound and optical coherence tomography. However, there is potential risk during these invasive procedures, such as severe myocardial ischemia or fatal arrhythmia.
Presently available imaging test for coronary artery disease including multi-detector computed tomography angiography (MDCTA) with high diagnostic accuracy to evaluate coronary artery stenosis. However, the diagnostic accuracy of MDCTA in patients with VSA is lacking.
Therefore, more efficient and safe noninvasive diagnostic method is required for the detection of angina-like attacks patients.
519 studies on the registry are indexed under Angina Pectoris; 82 are open to participants now.
This study's planned enrollment of 150 is above the median of 123 across 336 interventional studies indexed under Angina Pectoris.
Browse Angina Pectoris studies →Dong-A University is the lead sponsor of 33 studies on the registry; 1 is open to participants now.
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Exclusion Criteria:
A positive finding for coronary angiography with an ergonovine provocation test is defined as transient, total, or sub-total occlusion (\>90% stenosis) with signs/symptoms of myocardial ischemia (chest pain and ischemic ECG change).
Procedure: Positive CAG with EG test
Negative test: less than 70% luminal narrowing, without chest pain or ST-segment changes after ergonovine coronary injection
Procedure: Negative CAG with EG test
A positive finding for coronary angiography with an ergonovine provocation test is defined as transient, total, or sub-total occlusion (\>90% stenosis) with signs/symptoms of myocardial ischemia (chest pain and ischemic ECG change).
Negative test: less than 70% luminal narrowing, without chest pain or ST-segment changes after ergonovine coronary injection
Characteristics of coronary lesion
1. Plaque composition: noncalcified plaque, which is \< 130 Hounsfield units(HU). Calcified plaque with a density of \> 130 HU. Mixed plaque: plaque area consisted of \> 50% of non-calcified plaque. 2. The remodeling index (RI) was calculated by dividing the cross-sectional lesion vessel-area by the reference vessel area.Positive remodeling was defined as RI \> 1.05, otherwise RI ≤0.95. 3. Significant stenosis is defined as stenosis in more than 50% of the coronary artery diameter.
Time frame: CAG will be performed after multidetector coronary CT, an expected average of 4 weeks.
Plan to share: Undecided
This study is status unknown, as verified in Jul 2020. You cannot join it, but the record below documents what was studied.
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Dong-A University