An interventional study of Blood transfusion in Compare Blood Age for Transfusion, sponsored by Makerere University. Completed at 1 site in Uganda. Open to participants aged 6 Months to 59 Months. Per ClinicalTrials.gov, last updated 2012-04-18.
Sponsored by Makerere University · Not applicable, Interventional, and Treatment
In resolving lactic acidosis among children with severe malarial anemia, there is no difference between those transfused with blood of longer storage compared to shorter storage age
Objective of the study is to evaluate the effect of blood storage age on resolution of lactic acidosis in children with severe malarial anemia.
Methods:
Children aged 6 - 59 months admitted to ACU with Severe Malarial Anemia (Hb \<5g/dl) and Lactic Acidosis (blood lactate >5 mmol /l), will be randomly assigned to receive either blood of shorter storage age (\<10 days) or longer storage age (21 -35 days) by gravity infusion as is the routine practice. 37 patients will be enrolled in each study arm. Physiological measurements namely blood lactate, oxygen saturation, Hemoglobin, Blood pressure, respiratory rate and pulse rate will be taken at baseline, during and after transfusion. The two groups will be compared. The primary outcome variable will be the proportion of children whose lactic acidosis resolves after 4 hrs of transfusion. 24hr mortality will be our secondary outcome.
194 studies on the registry are indexed under Acidosis; 31 are open to participants now.
This study's enrollment of 74 is above the median of 53 across 124 interventional studies indexed under Acidosis.
Browse Acidosis studies →Makerere University is the lead sponsor of 143 studies on the registry; 16 are open to participants now.
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Inclusion Criteria:Children aged 6 - 59 months admitted at Acute care Unit - Mulago hospital with;
Exclusion Criteria:
Short storage arm: Will receive blood (Packed red blood cells) of 1 (one) to 10 (ten) days in storage.
Biological: Blood transfusion
Will be transfused with blood ( packed red cells) of storage age 21- 35 days.
Biological: Blood transfusion
The short storage arm; children were transfused with packed red cells of storage age 1-10 days; while for the Long storage arm; were transfused with packed red cells of 21- 35 days in storage.
Effect of blood storage age on the resolution of lactic acidosis in children with severe malarial anemia at Mulago hospital
The proportion of transfused patients who resolve lactic acidosis within 4 hours of transfusion
Time frame: 4hrs
Effect of blood storage age on the resolution of lactic acidosis in children with severe malarial anemia at Mulago hospital
proportion of children who die within 24 hrs.
Time frame: 24 HRS
This study is completed, as verified in Apr 2012. You cannot join it, but the record below documents what was studied.
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Makerere University